Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors

European Neuropsychopharmacology

Volumn 21, Issue 4, 2011, Pages 306-315

  Pobbe, Roger L H ^a,b   Zangrossi, Helio ^b   Blanchard, D Caroline ^a,c   Blanchard, Robert J ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF HAWAII   (United States)

Author keywords

Anxiety; Dorsal periaqueductal gray; Dorsal raphe nucleus; Mouse defense test battery; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DORSAL RAPHE NUCLEUS; ESCAPE BEHAVIOR; EXPERIMENTAL TEST; MALE; MOUSE; MOUSE DEFENSE TEST BATTERY; NEUROMODULATION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PREDATOR STRESS; PRIORITY JOURNAL; RISK ASSESSMENT; SPECIES DIFFERENCE; THREAT;

ANIMALS; ANXIETY DISORDERS; BEHAVIOR, ANIMAL; ESCAPE REACTION; IMMOBILITY RESPONSE, TONIC; INFUSIONS, INTRAVENTRICULAR; MALE; MICE; NERVE TISSUE PROTEINS; NEURONS; PANIC DISORDER; PERIAQUEDUCTAL GRAY; RAPHE NUCLEI; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SPECIES SPECIFICITY;

EID: 79952362172     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.05.004     Document Type: Article

References (37)

1. Argyropoulos S.V., Sandford J.J., Nutt D.J. The psychobiology of anxiolytic drug. Part 2: pharmacological treatments of anxiety. Pharmacol. Ther. 2000, 88:213-227.
2. Blanchard D.C., Griebel G., Blanchard R.J. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neurosci. Biobehav. Rev. 2001, 25(3):205-218.
3. Blanchard D.C., Griebel G., Blanchard R.J. The mouse defense test battery: pharmacological and behavioral assays for anxiety and panic. Eur. J. Pharmacol. 2003, 463:97-116.
4. Blanchard D.C., Griebel G., Blanchard R.J. Conditioning and residual emotionality effects of predator stimuli: some reflections on stress and emotion. Prog. Neuro-Psychopharm. Biol. Psych. 2003, 27:1117-1185.
5. Blanchard R.J., Blanchard D.C. Antipredator defensive behaviors in a visible burrow system. J. Comp. Psychol. 1989, 103:70-82.
6. Blanchard R.J., Parmigiani S., Bjornson C., Masuda C., Weiss S.M., Blanchard D.C. Antipredator behavior of Swiss-Webster mice in a visible burrow system. Agress. Behav. 1995, 21:123-136.
7. Blier P., de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 1999, 21:91-98.
8. Canto-de-Souza A., Nunes-de-Souza R.L., Rodgers R.J. Anxiolytic-like effect of WAY-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience. Brain Res. 2002, 928:50-59.
9. De Boer S.F., Koolhaas J.M. Defensive burying in rodents: ethology, neurobiology and psychopharmacology. Eur. J. Pharmacol. 2003, 463:145-161.
10. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defense. J. Psychopharmacology 1991, 5:305-315.
11. Graeff F.G. On serotonin and experimental anxiety. Psychopharmacology (Berl) 2002, 163:467-476.
12. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 2004, 28:239-259.
13. Graeff F.G., Ferreira Netto C., Zangrossi H. The elevated T-maze as an experimental model of anxiety. Neurosci. Biobehav. Rev. 1998, 23(2):237-246.
14. Graeff F.G., Viana M.B., Mora P.O. Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze. Pharmacol. Biochem. Behav. 1996, 53:171-177.
15. Graeff F.G., Zangrossi H. Animal models of anxiety disorders. Textbook of Biological Psychiatry 2002, 879-893. Wiley, London. H. D'Haenen, J.A. den Boer, H. Westenberg, P. Willner (Eds.).
16. Griebel G., Blanchard D.C., Agnes R.S., Blanchard R.J. Differential modulation of antipredator defensive behavior in Swiss-Webster mice following acute and chronic administration of imipramine and fluoxetine. Psychopharmacology (Berl) 1995, 120:57-66.
17. Griebel G., Blanchard D.C., Jung A., Lee J.C., Masuda C.K., Blanchard R.J. Further evidence that the mouse defense test battery is useful for screening anxiolytic and panicolytic drugs: effects of acute and chronic treatment with alprazolam. Neuropharmacology 1995, 34:1625-1633.
18. Haddjeri N., Lavoie N., Blier P. Electrophysiological evidence for the tonic activation of 5-HT1A autoreceptors in the rat dorsal raphe nucleus. Neuropsycopharmacology 2004, 29:1800-1806.
19. Hajós M., Hoffmann W.E., Tetko I.V., Hyland B., Sharp T., Villa A.E.P. Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT1A receptors. Neurosci. Lett. 2001, 304:129-132.
20. Hoyer D., Hannon J.P., Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 2002, 71:533-554.
21. Liu R.J., Lambe E.K., Aghajanian G.K. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. Eur. J. Neurosci. 2005, 21:945-958.
22. Lowry C.A., Johnson P.L., Hay-Schmidt A., Mikkelsen J., Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress 2005, 8:233-246.
23. Maron E., Shlik J. Serotonin function in panic disorder: important, but why?. Neuropsychopharmacology 2006, 31:1-11.
24. McNaughton N., Corr P.J. A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance. Neurosci. Biobehav. Rev. 2004, 28:285-305.
25. Millan M.J. The neurobiology and control of anxious states. Prog. Neurobiol. 2003, 70:83-244.
26. Millan M.J. Serotonin 5-HT2c receptors as a target for the treatment of depressive and anxiety states: focus on novel therapeutic strategies. Therapie 2006, 60:441-460.
27. Paxinos G., Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates 2001, Academic Press, San Diego. Second edition.
28. Pinheiro S.H., Zangrossi H., Del-Ben C.M., Graeff F.G. Elevated mazes as animal models of anxiety: effects of serotonergic agents. An. Acad. Bras. Cienc. 2007, 79:71-85.
29. Pobbe R.L.H., Zangrossi H. 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray mediate the antipanic-like effect induced by the stimulation of serotonergic neurons in the dorsal raphe nucleus. Psychopharmacology (Berl) 2005, 183:314-321.
30. Sena L.M., Bueno C., Pobbe R.L.H., Andrade T.G.C.S., Zangrossi H., Viana M.B. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav. Brain Res. 2003, 142:125-133.
31. Soares V.P., Zangrossi H. Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res. Bull. 2004, 64:181-188.
32. Tao R., Auerbach S.B. Regulation of serotonin release by GABA and excitatory amino acids. J. Psychopharmacology 2000, 14:100-113.
33. Viana M.B., Graeff F.G., Löschmann P.A. Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray. Pharmacol. Biochem. Behav. 1997, 58:167-172.
34. Viana M.B., Tomaz C., Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 1994, 49:549-554.
35. Yang M., Augustsson H., Markham C.M., Hubbard D.T., Webster D., Wall P.M., Blanchard R.J., Blanchard D.C. The rat exposure test: a model of mouse defensive behaviors. Physiol. Behav. 2004, 81:465-473.
36. Zangrossi H., Graeff F.G. Behavioral validation of the elevated T-maze, a new animal model of anxiety. Brain Res. Bull. 1997, 44:1-5.
37. Zanoveli J.M., Nogueira R.L., Zangrossi H. Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze. Eur. J. Pharmacol. 2003, 473:153-161.