The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts

Journal of Pharmacological Sciences

Volumn 115, Issue 2, 2011, Pages 230-234

  Kobayashi, Daisaku ^a   Kusama, Miho ^a   Onda, Masaaki ^b   Nakahata, Norimichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Daiichi Fine Chemical Co Ltd   (Japan)

Author keywords

Collagen; Keratinocyte; Pantothenic acid

Indexed keywords

COLLAGEN; CYTOKERATIN 10; KERATINOCYTE GROWTH FACTOR; PANTOTHENIC ACID; PROCOLLAGEN; PROCOLLAGEN 1A1; PROCOLLAGEN 1A2; PROCOLLAGEN 4A2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SECRETION; CULTURE MEDIUM; DRUG ACTIVITY; FIBROBLAST; HUMAN; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PANTOTHENIC ACID DEFICIENCY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SKIN FUNCTION; VITAMIN DEFICIENCY;

EID: 79952352916     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10224SC     Document Type: Article

References (15)

1. Olson RE, Kaplan NO. The effect of pantothenic acid deficiency upon the coenzyme A content and pyruvate utilization of rat and duck tissues. J Biol Chem. 1948;175:515-529.
2. Eisenstein AB. Pantothenic acid and adrenocortical hormone secretion. Endocrinology. 1957;60:298-302.
3. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol. 2002;3:427-433. (Pubitemid 34879434)
4. Weimann BI, Hermann D. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Int J Vitam Nutr Res. 1999;69:113-119. (Pubitemid 29170583)
5. Wiederholt T, Heise R, Skazik C, Marquardt Y, Joussen S, Erdmann K, et al. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009;18:969-978.
6. Matus CE, Ehrenfeld P, Pavicic F, Sarmiento JM, Astroza A, Sanchez T, et al. Activation of kinin B receptor triggers differentiation of cultured human keratinocytes. Br J Dermatol. 2008;159:792-803.
7. Ohkubo S, Nagata K, Nakahata N. Adenosine uptake-dependent C6 cell growth inhibition. Eur J Pharmacol. 2007;577:35-43. (Pubitemid 47632522)
8. Kobayashi D, Ohkubo S, Nakahata N. Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes. Eur J Pharmacol. 2007;573:249-252. (Pubitemid 47464228)
9. Nishi K, Inoue H, Schnier JB, Rice RH. Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. J Cell Biochem. 2009;106:63-72.
10. Jerome-Morais A, Rahn HR, Tibudan SS, Denning MF. Role for protein kinase C-α in keratinocyte growth arrest. J Invest Dermatol. 2009;129:2365-2375.
11. 2+-induced differentiation of human keratinocytes. J Biol Chem. 2007;282:22582-22591.
12. Koivisto L, Jiang G, Hakkinen L, Chan B, Larjava H. HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3α. Exp Cell Res. 2006;312:2791-2805.
13. Prockop DJ, Kivirikko KI. Heritable diseases of collagen. N Engl J Med. 1984;311:376-386. (Pubitemid 14096748)
14. Murray JC, Stingl G, Kleinman HK, Martin GR, Katz SI. Epidermal cells adhere preferentially to type IV (basement membrane) collagen. J Cell Biol. 1979;80:197-202. (Pubitemid 9097517)
15. Yang J, Meyer M, Muller AK, Bohm F, Grose R, Dauwalder T, et al. Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol. 2010;188:935-952.