Ultrasound-Induced Expression of a Heat Shock Promoter-Driven Transgene Delivered in the Kidney by Genetically Modified Mesenchymal Stem Cells: A Feasibility Study

MRI-Guided Focused Ultrasound Surgery

Volumn , Issue , 2007, Pages 171-179

  Letavernier, Béatrice ^a   Salomir, Rares ^a   Delmas, Yahsou ^a   Rome, Claire ^b   Couillaud, Franck ^b   Desmoulière, Alexis ^a   Dubus, Isabelle ^a   Moreau Gaudry, François ^a   Grosset, Christophe ^a   Hauger, Olivier ^b   Rosenbaum, Jean ^a   Grenier, Nicolas ^b   Combe, Christian ^a   Ripoche, Jean ^a   Moonen, Chrit ^b  

^a INSERM   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79952352336     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3109/9781420019933-17     Document Type: Chapter

References (20)

1. Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004; 8:301-316.
2. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 2000; 28:875-884.
3. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004; 95:9-20.
4. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Systemic infusion of FLK1(þ) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004; 78:83-88.
5. Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003; 100:8407-8411.
6. Bacigalupo A. Mesenchymal stem cells and haematopoietic stem cell transplantation. Best Pract Res Clin Haematol 2004; 17:387-399.
7. Bensidhoum M, Chapel A, Francois S, et al. Homing of in vitro expanded Stro-1- or Stro-1þ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment. Blood 2004; 103:3313-3319.
8. Bos C, Delmas Y, Desmouliere A, et al. In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 2004; 233: 781-789.
9. Madio DP, van Gelderen P, DesPres D, et al. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression. J Magn Reson Imaging 1998; 8:101-104.
10. Smith RC, Machluf M, Bromley P, Atala A, Walsh K. Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo. Hum Gene Ther 2002; 13:697-706.
11. Mougenot C, Salomir R, Palussiere J, Grenier N, Moonen CT. Automatic spatial and temporal temperature control for MR-guided focused ultrasound using fast 3D MR thermometry and multispiral trajectory of the focal point. Magn Reson Med 2004; 52:1005-1015.
12. Salomir R, Vimeux FC, de Zwart JA, Grenier N, Moonen CT. Hyperthermia by MR-guided focused ultrasound: accurate temperature control based on fast MRI and a physical model of local energy deposition and heat conduction. Magn Reson Med 2000; 43:342-347.
13. Vekris A, Maurange C, Moonen C, et al. Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter. J Gene Med 2000; 2:89-96.
14. Guilhon E, Voisin P, de Zwart JA, et al. Spatial and temporal control of transgene expression in vivo using a heat-sensitive promoter and MRI-guided focused ultrasound. J Gene Med 2003; 5:333-342.
15. Borrelli MJ, Schoenherr DM, Wong A, Bernock LJ, Corry PM. Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells. Cancer Res 2001; 61:1113-1121.
16. Xu L, Zhao Y, Zhang Q, Li Y, Xu Y. Regulation of transgene expression in muscles by ultrasound-mediated hyperthermia. Gene Ther 2004; 11:894-900.
17. Silcox CE, Smith RC, King R, et al. MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound Med Biol 2005; 31:965-970.
18. Palussiere J, Salomir R, Le Bail B, et al. Feasibility of MR-guided focused ultrasound with real-time temperature mapping and continuous sonication for ablation of VX2 carcinoma in rabbit thigh. Magn Reson Med 2003; 49:89-98.
19. Salomir R, Palussiere J, Vimeux FC, et al. Local hyperthermia with MR-guided focused ultrasound: spiral trajectory of the focal point optimized for temperature uniformity in the target region. J Magn Reson Imaging 2000; 12:571-583.
20. Hynynen K, McDannold N. MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress. Int J Hyperthermia 2004; 20:725-737.