A murine model of xenotransplantation of human glioblastoma with imunosupression by orogastric cyclosporin;Modelo murino de xenotransplante de glioblastoma humano com imunossupressão utilizando ciclosporina orogástrica

Arquivos de Neuro-Psiquiatria

Volumn 69, Issue 1, 2011, Pages 112-117

  Cunha, Alexandre M ^a,b   Nascimento, Fernanda S ^a   Amaral, Jane C O F ^a   Konig, Sandra ^a   Takiya, Crhistina M ^a   Neto, Vivaldo M ^a,c   Rocha, Eduardo ^a   Souza, Jorge P B M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL UNIVERSITÁRIO PEDRO ERNESTO   (Brazil)

^c MCT   (Brazil)

Author keywords

Animal model; Cyclosporin; Glioblastoma; Wistar rats; Xenotransplant

Indexed keywords

CYCLOSPORIN; GLIAL FIBRILLARY ACIDIC PROTEIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER TRANSPLANTATION; CONTROLLED STUDY; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; RAT; SUBCUTANEOUS TISSUE; TUMOR GROWTH; TUMOR VOLUME; XENOTRANSPLANTATION;

EID: 79952348385     PISSN: 0004282X     EISSN: 16784227     Source Type: Journal    
DOI: 10.1590/s0004-282x2011000100021     Document Type: Article

References (36)

1. Collins VP. Brain tumors: classification and genes. J Neurol Neurosurg Psychiatry 2004;75:2-11.
2. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P. Grading of astrocytomas. A simple and reproducible method. Cancer 1998;62:2152-2165.
3. Deangelis LM. Brain tumors. N Engl J Med 2001;344:114-123.
4. Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61:215-225.
5. Louis DN, Holland EC, Cairncross JG. Glioma classification: a molecular reappraisal. Am J Pathol 2001;159:779-786.
6. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of tumours of the central nervous system. Lyon: IARC; 2007.
7. Pietsch T, Wiestler OD. Molecular neuropathology of astrocytic brain tumors. J Neurooncol 1997;35:211-222.
8. Salcman M. Glioblastoma and malignant astrocytoma. In: Kaye AH, Laws ER (Eds). Brain tumors. New York: Churchill Livingstone; 1995:449-477.
9. Vajkoczy P, Menger MD. Vascular microenviroment in gliomas. J Neurooncol 2000;50:99-108.
10. Ichimura K, Ohgaki H, Kleihues P, Collins VP. Molecular pathogenesis of astrocytic tumours. J Neurooncol 2004;70:137-160.
11. Lefrane F, Brotchi J, Kiss R. Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J Clin Oncol 2005;23:2411-2422.
12. Maher EA, Furnari FB, Bachoo RM, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001;15:1311-1333.
13. Dai C, Holland EC. Glioma models. Biochim Biophys Acta 2001;1551:19-27.
14. Crafts D, Wilson CB. Animal models of brain tumors. Natl Cancer Inst Monog 1977;46:11-17.
15. Peterson DL, Sheridan PJ, Brown Jr. WE. Animal models for brain tumors: historical perspectives and future directions. J Neurosurg 1994;80:865-876.
16. Goldbrunner RH. Models for assessment of angiogenesis in gliomas. J Neurooncol 2000;50:53-60.
17. Leuraud P, Taillandier L, Aquirre-Curz L. Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice. Br J Cancer 2003;89:2327-2332.
18. Watanabe K, Sakamoto M, Somiya M, Amin MR, Kamitani H, Watanabe T. Feasibility and limitations of the rat model by C6 gliomas implanted at the subcutaneous region. Neurol Res 2002;24:485-490.
19. Arosarena O, Guerin C, Brem H, Laterra J. Endothelial differentiation in intracerebral and subcutaneous experimental gliomas. Brain Res 1994;640: 98-104.
20. Bersen HJJA, Rijken PFJW, Hagemeier NEM, Van Der Kogel AJ. A quantitative analysis of vascularization and perfusion of human glioma xenografts at different implantation sites. Microvasc Res 1999;57:244-257.
21. Faria J, Romão L, Martins S, et al. Interactive properties of human glioblastoma cells with brain neurons in culture and neuronal modulation of glial laminin organization. Differentiation 2006;74:562-572.
22. Bigner SH, Humphrey PA, Wong AJ, Vogelstein B, Mark J, Friedman HS, et al. Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res 1990;50:8017-8022.
23. Engebraaten O, Hjortland GO, Hirschberg H, Fodstad O. Growth of precultured human glioma specimens in nude rat brain. J Neurosurg 1999;90:125-132.
24. Guillamo JS, Lisovoski F, Christov C, et al. Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain. J Neurooncol 2001;52:205-215.
25. Krushelnycky BW, Farr-Jones MA, Mielke B, McKean JD, Weir BK, Petruc KC. Development of large-animal human brain tumor xenograft model in immunosuppressed cats. Cancer Res 1991;51:2430-2437.
26. Mathiesen T, Collins VP, Olson L, Granholm L. Prolonged survival and vascularization of xenografted human glioblastoma cells in the central nervous system of cyclosporine A treated rats. Cancer Lett 1989;44:151-156.
27. Calne R. Cyclosporine as a milestone in immunosuppression. Transplant Proc 2004;36(Suppl):S13-S15.
28. Matsuda S, Koyasu S. Mechanisms of action of cyclosporine. Immunopharmacology 2000;47:119-125.
29. Moseniak G, Figiel I, Kaminska B. Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J Neurochem 1997;68:1142-1149.
30. Pyrzynska B, Serrano M, Martinez AC, Kaminska B. Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A. J Biol Chem 2002;277:14102-14108.
31. Strojnik T, Kavalar R, Lah TT. Experimental model and immunohistochemical analyses of U87 human glioblastoma cell xenografts in immunosuppressed rat brains. Anticancer Res 2006;26:2887-2900.
32. Yoshida D, Takahashi H, Teramoto A. Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model. Neurosurgery 2004;54:1213-1220.
33. Mourad PD, Farrel L, Stamps LD, Chicoine MR, Silbergeld DL. Why are systemic glioblastoma metastases rare? Systemic and cerebral growth of mouse glioblastoma. Surg Neurol 2005;63:511-519.
34. Schweitzer T, Vince GH, Herbold C, Roosen K, Tonn JC. Extraneural metastases of primary brain tumors. J Neurooncol 2001;53:107-114.
35. Antunes L, Angioi-Duprez KS, Bracard SR, et al. Analysis of tissue chimerism in nude mouse brain and abdominal xenograft models of human glioblastoma multiforme: what does it tell us about the models and about glioblastoma biology and therapy? J Histochem Cytochem 2000;48:847-858.
36. Killion JJ, Radinsky R, Fidler IJ. Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev 1998; 17:279-284.