Lymphoid tissue collagen deposition in HIV-infected patients correlates with the imbalance between matrix metalloproteinases and their inhibitors

Journal of Infectious Diseases

Volumn 203, Issue 6, 2011, Pages 810-813

  Diaz, Alba ^a   García, Felipe ^a   Mozos, Anna ^a   Caballero, Miguel ^a   León, Agathe ^a   Martinez, Antonio ^a   Gil, Cristina ^a   Plana, Montserrat ^a   Gallart, Teresa ^a   Gatell, Jose M ^a   Alós, Llúcia ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COLLAGEN; EFAVIRENZ; GELATINASE A; GELATINASE B; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNE RESPONSE; LYMPHOID TISSUE; MALE; PRIORITY JOURNAL;

ADULT; ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; COLLAGEN; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIV INFECTIONS; HUMANS; LYMPHOID TISSUE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PALATINE TONSIL; POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 79952340014     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq129     Document Type: Article

References (15)

1. Alos L, Navarrete P, Morente V, et al. Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence. Mod Pathol 2005; 18:127-36. (Pubitemid 40128105)
2. Martinez E, Arnedo M, Giner V, et al. Lymphoid tissue viral burden and duration of viral suppression in plasma. AIDS 2001; 15:1477-82. (Pubitemid 32744594)
3. Navarrete P, Morente V, Garcia F, et al. Predictors of tonsillar tissue HIV-1 viral burden at baseline and after 1 year of antiretroviral therapy. Antivir Ther 2003; 8:635-7. (Pubitemid 38057110)
4. Diaz A, Alos L, Leon A, et al. Factors associated with collagen deposition in lymphoid tissue in long-term treated HIV-infected patients. AIDS 2010; 24:2029-39.
5. + T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. Semin Immunol 2008; 20:181-6.
6. Schacker TW, Brenchley JM, Beilman GJ, et al. Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4 T cells in human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 2006; 13:556-60. (Pubitemid 43736456)
7. Garrido M, Mozos A, Martinez A, et al. HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infection. J Acquir Immune Defic Syndr 2007; 46:268-74. (Pubitemid 350287351)
8. Mozos A, Garrido M, Carreras J, et al. Redistribution of FOXP3-positive regulatory T cells from lymphoid tissues to peripheral blood in HIV-infected patients. J Acquir Immune Defic Syndr 2007; 46:529-37. (Pubitemid 350191045)
9. Larrousse M, Laguno M, Segarra M, et al. Noninvasive diagnosis of hepatic fibrosis in HIV/HCV-coinfected patients. J Acquir Immune Defic Syndr 2007; 46:304-11. (Pubitemid 350287357)
10. Mastroianni CM, Liuzzi GM, D'Ettorre G, et al. Matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 in plasma of patients co-infected with HCV and HIV. HIV Clin Trials 2002; 3:310-5. (Pubitemid 34830682)
11. Mastroianni CM, Liuzzi GM. Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategies. Trends Mol Med 2007; 13:449-59. (Pubitemid 350086978)
12. Biancotto A, Grivel JC, Iglehart SJ, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood 2007; 109:4272-9. (Pubitemid 46743393)
13. McKaig BC, McWilliams D, Watson SA, Mahida YR. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 2003; 162:1355-60. (Pubitemid 36350679)
14. Peng J, Gurantz D, Tran V, Cowling RT, Greenberg BH. Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis. Circ Res 2002; 91:1119-26. (Pubitemid 36076360)
15. Colmenero J, Bataller R, Sancho-Bru P, et al. Effects of losartan on hepatic expression of non-phagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol 2009; 297:726-34.