Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms

Journal of Pharmacological Sciences

Volumn 115, Issue 2, 2011, Pages 249-253

  Jutabha, Promsuk ^a   Anzai, Naohiko ^a   Kimura, Toru ^b   Taniguchi, Atsuo ^b   Urano, Wako ^b   Yamanaka, Hisashi ^b   Endou, Hitoshi ^a   Sakurai, Hiroyuki ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Diuretic; Single nucleotide polymorphism; Urate

Indexed keywords

4 AMINOHIPPURIC ACID; BUMETANIDE; DIURETIC AGENT; ESTRONE SULFATE; SODIUM PHOSPHATE COTRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER 4; UNCLASSIFIED DRUG; URATE;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; DRUG DISPOSITION; GENE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; MOLECULAR CLONING; NONHUMAN; OOCYTE; SINGLE NUCLEOTIDE POLYMORPHISM; SLC17A3 GENE; XENOPUS;

EID: 79952338197     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10228SC     Document Type: Article

References (15)

1. Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, et al. The genetic polymorphism of drug transporters: functional analysis approaches. Pharmacogenomics. 2004;5:67-99. (Pubitemid 38088481)
2. Anzai N, Endou H. Drug transport in the kidney. In: You G, Morris ME, editors. Drug transporters molecular characterization and role in drug disposition. Hoboken: John Wiley & Sons, Inc.; 2007. p. 463-494.
3. Sakata T, Anzai N, Shin HJ, Noshiro R, Hirata T, Yokoyama H, et al. Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Biochem Biophys Res Commun. 2004;313:789-793. (Pubitemid 38021900)
4. Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci. 2006;95:25-36.
5. Sakata T, Anzai N, Kimura T, Miura D, Fukutomi T, Takeda M, et al. Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms. J Pharmacol Sci. 2010;113:263-266.
6. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005;15:201-209.
7. Iharada M, Miyaji T, Fujimoto T, Hiasa M, Anzai N, Omote H, et al. Type 1 sodium dependent phosphate transporter (SLC17A1 protein) is a Cl--dependent urate exporter. J Biol Chem. 2010;285:26107-26113.
8. Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, et al. Human sodium-phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010;285:35123-35132.
9. Nakamura M, Anzai N, Jutabha P, Sato H, Sakurai H, Ichida K. Concentration-dependent inhibitory effect of irbesartan on renal uric acid transporters. J Pharmacol Sci. 2010;114:115-118.
10. Jutabha P, Kanai Y, Hosoyamada M, Chairoungdua A, Kim DK, Iribe Y, et al. Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule. J Biol Chem. 2003;278:27930-27938. (Pubitemid 36899987)
11. Shibui A, Tsunoda T, Seki N, Suzuki Y, Sugane K, Sugano S. Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter. J Hum Genet. 1999;44:190-192. (Pubitemid 29219906)
12. Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372:1953-1961.
13. Anzai N, Jutabha P, Endou H. Renal solute transporters and their relevance to serum urate disorder. Curr Hypertens Rev. 2010;6:148-154.
14. Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, et al. NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic. J Inherit Metab Dis. 2004;27:725-733. (Pubitemid 39433599)
15. Ravnan SL, Ravnan MC, Deedwania PC. Pharmacotherapy in congestive heart failure: diuretic resistance and strategies to overcome resistance in patients with congestive heart failure. Congest Heart Fail. 2002;8:80-85. (Pubitemid 34303470)