메뉴 건너뛰기




Volumn 6, Issue 3, 2010, Pages 148-154

Renal solute transporters and their relevance to serum urate disorder

Author keywords

Gout; Hyperuricemia; Hypouricemia; PDZ; Transporter; Urate

Indexed keywords

ANION TRANSPORT PROTEIN; ANTIPORTER; BREAST CANCER RESISTANCE PROTEIN; GLUCOSE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER; MULTIDRUG RESISTANCE PROTEIN 4; PROTEIN GLUT9; PROTEIN NPT4; PROTEIN OAT1; PROTEIN OAT10; PROTEIN OAT2; PROTEIN OAT3; PROTEIN OAT4; PROTEIN SMCT1; PROTEIN SMCT2; PROTEIN URAT1; SODIUM PHOSPHATE COTRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER 1; UNCLASSIFIED DRUG; URIC ACID;

EID: 77958031682     PISSN: 15734021     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340210791936732     Document Type: Review
Times cited : (22)

References (44)
  • 1
    • 33846837206 scopus 로고    scopus 로고
    • New insights into renal transport ofurate
    • Anzai, N, Kanai Y, Endou H. New insights into renal transport ofurate. Curr Opin Rheumatol 2007; 19: 151-7.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 151-157
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 2
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identificationof a renal urate anion exchanger that regulates blood uratelevels
    • Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identificationof a renal urate anion exchanger that regulates blood uratelevels. Nature 2002; 417: 447-52.
    • (2002) Nature , vol.417 , pp. 447-452
    • Enomoto, A.1    Kimura, H.2    Chairoungdua, A.3
  • 3
    • 1842732504 scopus 로고    scopus 로고
    • Human organic aniontransporter 4 is a renal apical organic anion/dicarboxylateexchanger in the proximal tubules
    • Ekaratanawong S, Anzai N, Jutabha P, et al. Human organic aniontransporter 4 is a renal apical organic anion/dicarboxylateexchanger in the proximal tubules. J Pharmacol Sci 2004; 94: 297-304.
    • (2004) J Pharmacol Sci , vol.94 , pp. 297-304
    • Ekaratanawong, S.1    Anzai, N.2    Jutabha, P.3
  • 4
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci 2006; 100: 411-26.
    • (2006) J Pharmacol Sci , vol.100 , pp. 411-426
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 5
    • 0041344601 scopus 로고    scopus 로고
    • Identification of anovel voltage-driven organic anion transporter present at apicalmembrane of renal proximal tubule
    • Jutabha P, Kanai Y, Hosoyamada H, et al. Identification of anovel voltage-driven organic anion transporter present at apicalmembrane of renal proximal tubule. J Biol Chem 2003; 278: 27930-8.
    • (2003) J Biol Chem , vol.278 , pp. 27930-27938
    • Jutabha, P.1    Kanai, Y.2    Hosoyamada, H.3
  • 6
    • 7244236578 scopus 로고    scopus 로고
    • Expression of slc5a8 in kidneyand its role in Na(+)-coupled transport of lactate
    • Gopal E, Fei YJ, Sugawara M, et al. Expression of slc5a8 in kidneyand its role in Na(+)-coupled transport of lactate. J Biol Chem 2004; 279: 44522-32.
    • (2004) J Biol Chem , vol.279 , pp. 44522-44532
    • Gopal, E.1    Fei, Y.J.2    Sugawara, M.3
  • 7
    • 35848971238 scopus 로고    scopus 로고
    • Cloning and functionalcharacterization of human SMCT2 (SLC5A12) and expression patternof the transporter in kidney
    • Gopal E, Umapathy NS, Martin PM, et al. Cloning and functionalcharacterization of human SMCT2 (SLC5A12) and expression patternof the transporter in kidney. Biochim Biophys Acta 2007; 1768: 2690-7.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 2690-2697
    • Gopal, E.1    Umapathy, N.S.2    Martin, P.M.3
  • 8
    • 47749112096 scopus 로고    scopus 로고
    • Identification of a new urate andhigh affinity nicotinate transporter, hOAT10 (SLC22A13)
    • Bahn A, Hagos Y, Reuter S, et al. Identification of a new urate andhigh affinity nicotinate transporter, hOAT10 (SLC22A13). J BiolChem 2008; 283: 16332-41.
    • (2008) J Biol Chem , vol.283 , pp. 16332-16341
    • Bahn, A.1    Hagos, Y.2    Reuter, S.3
  • 9
    • 41349103917 scopus 로고    scopus 로고
    • SLC2A9 is a newly identifiedurate transporter influencing serum urate concentration, urate excretionand gout
    • Vitart V, Rudan I, Hayward C, et al. SLC2A9 is a newly identifiedurate transporter influencing serum urate concentration, urate excretionand gout. Nat Genet 2008; 40: 437-42.
    • (2008) Nat Genet , vol.40 , pp. 437-442
    • Vitart, V.1    Rudan, I.2    Hayward, C.3
  • 10
    • 55249096942 scopus 로고    scopus 로고
    • Plasma urate level is directlyregulated by a voltage-driven urate efflux transporter URATv1(SLC2A9) in humans
    • Anzai N, Ichida K, Jutabha P, et al. Plasma urate level is directlyregulated by a voltage-driven urate efflux transporter URATv1(SLC2A9) in humans. J Biol Chem 2008; 283: 26834-8.
    • (2008) J Biol Chem , vol.283 , pp. 26834-26838
    • Anzai, N.1    Ichida, K.2    Jutabha, P.3
  • 12
    • 8544277306 scopus 로고    scopus 로고
    • The multivalent PDZdomain-containing protein PDZK1 regulates transport activity ofrenal urate-anion exchanger URAT1 via its C terminus
    • Anzai N, Miyazaki H, Noshiro R, et al. The multivalent PDZdomain-containing protein PDZK1 regulates transport activity ofrenal urate-anion exchanger URAT1 via its C terminus. J BiolChem 2004; 279: 45942-50.
    • (2004) J Biol Chem , vol.279 , pp. 45942-45950
    • Anzai, N.1    Miyazaki, H.2    Noshiro, R.3
  • 13
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and molecularanalysis of patients with renal hypouricemia in Japan-influence ofURAT1 gene on urinary urate excretion
    • Ichida K, Hosoyamada M, Hisatome I, et al. Clinical and molecularanalysis of patients with renal hypouricemia in Japan-influence ofURAT1 gene on urinary urate excretion. J Am Soc Nephrol 2004; 15: 164-73.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 164-173
    • Ichida, K.1    Hosoyamada, M.2    Hisatome, I.3
  • 14
    • 3543124167 scopus 로고    scopus 로고
    • The renalspecifictransporter mediates facilitative transport of organic anionsat the brush border membrane of mouse renal tubules
    • Imaoka T, Kusuhara H, Adachi-Akahane S, et al. The renalspecifictransporter mediates facilitative transport of organic anionsat the brush border membrane of mouse renal tubules. J Am SocNephrol 2004; 15: 2012-22.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2012-2022
    • Imaoka, T.1    Kusuhara, H.2    Adachi-Akahane, S.3
  • 15
    • 28144462450 scopus 로고    scopus 로고
    • Involvement of uric acid transporter in increased renal clearance ofthe xanthine oxidase inhibitor oxypurinol induced by a uricosuricagent, benzbromarone
    • Iwanaga T, Kobayashi D, Hirayama M, Maeda T, Tamai I. Involvement of uric acid transporter in increased renal clearance ofthe xanthine oxidase inhibitor oxypurinol induced by a uricosuricagent, benzbromarone. Drug Metab Dispos 2005; 33: 1791-5.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1791-1795
    • Iwanaga, T.1    Kobayashi, D.2    Hirayama, M.3    Maeda, T.4    Tamai, I.5
  • 17
    • 77958030152 scopus 로고    scopus 로고
    • Interactions of urate transporterURAT1 in human kidney with uricosuric drugs
    • in press
    • Shin HJ, Takeda M, Enomoto A, et al. Interactions of urate transporterURAT1 in human kidney with uricosuric drugs. Nephrology 2010 in press.
    • (2010) Nephrology
    • Shin, H.J.1    Takeda, M.2    Enomoto, A.3
  • 18
    • 9244264985 scopus 로고    scopus 로고
    • Molecular cloning and characterizationof a human urate transporter (hURAT1) gene promoter
    • Li T, Walsh JR, Ghishan FK, Bai L. Molecular cloning and characterizationof a human urate transporter (hURAT1) gene promoter. Biochim Biophys Acta 2004; 1681: 53-8.
    • (2004) Biochim Biophys Acta , vol.1681 , pp. 53-58
    • Li, T.1    Walsh, J.R.2    Ghishan, F.K.3    Bai, L.4
  • 19
    • 36348965458 scopus 로고    scopus 로고
    • Regulation of tissuespecificexpression of the human and mouse urate transporter 1gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation
    • Kikuchi R, Kusuhara H, Hattori N, et al. Regulation of tissuespecificexpression of the human and mouse urate transporter 1gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. Mol Pharmacol 2007; 72: 1619-25.
    • (2007) Mol Pharmacol , vol.72 , pp. 1619-1625
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3
  • 20
    • 37349008492 scopus 로고    scopus 로고
    • The GLUT9 gene is associatedwith serum uric acid levels in Sardinia and Chianti cohorts
    • Li S, Sanna S, Maschio A, et al. The GLUT9 gene is associatedwith serum uric acid levels in Sardinia and Chianti cohorts. PLoSGenet 2007; 3: e194.
    • (2007) PLoS Genet , vol.3
    • Li, S.1    Sanna, S.2    Maschio, A.3
  • 21
    • 41449093735 scopus 로고    scopus 로고
    • SLC2A9 influences uric acidconcentrations with pronounced sex-specific effects
    • Döring A, Gieger C, Mehta D, et al. SLC2A9 influences uric acidconcentrations with pronounced sex-specific effects. Nat Genet 2008; 40: 430-6.
    • (2008) Nat Genet , vol.40 , pp. 430-436
    • Döring, A.1    Gieger, C.2    Mehta, D.3
  • 22
    • 1942437498 scopus 로고    scopus 로고
    • Identification and characterization of human glucosetransporter-like protein-9 (GLUT9): Alternative splicing alterstrafficking
    • Augustin R, Carayannopoulos MO, Dowd LO, Phay JE, Moley JF,Moley KH. Identification and characterization of human glucosetransporter-like protein-9 (GLUT9): alternative splicing alterstrafficking. J Biol Chem 2004; 279: 16229-36.
    • (2004) J Biol Chem , vol.279 , pp. 16229-16236
    • Augustin, R.1    Carayannopoulos, M.O.2    Dowd, L.O.3    Phay, J.E.4    Moley, J.F.5    Moley, K.H.6
  • 24
    • 75149114710 scopus 로고    scopus 로고
    • Homozygous SLC2A9mutations cause severe renal hypouricemia
    • Dinour D, Gray NK, Campbell S, et al. Homozygous SLC2A9mutations cause severe renal hypouricemia. J Am Soc Nephrol 2010; 21: 64-72.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 64-72
    • Dinour, D.1    Gray, N.K.2    Campbell, S.3
  • 25
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulatorof urate homeostasis and its genetic inactivation induces hyperuricosuriaand urate nephropathy
    • U S A
    • Preitner F, Bonny O, Laverrière A, et al. Glut9 is a major regulatorof urate homeostasis and its genetic inactivation induces hyperuricosuriaand urate nephropathy. Proc Natl Acad Sci U S A 2009; 106: 15501-6.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverrière, A.3
  • 27
    • 33846692496 scopus 로고    scopus 로고
    • Human renalorganic anion transporter 4 operates as an asymmetric urate transporter
    • Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A. Human renalorganic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol 2007; 18: 430-9.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 430-439
    • Hagos, Y.1    Stein, D.2    Ugele, B.3    Burckhardt, G.4    Bahn, A.5
  • 28
    • 40549090278 scopus 로고    scopus 로고
    • Involvement of uric acidtransporters in alteration of serum uric acid level by angiotensin IIreceptor blockers
    • Sato M, Iwanaga T, Mamada H, et al. Involvement of uric acidtransporters in alteration of serum uric acid level by angiotensin IIreceptor blockers. Pharm Res 2008; 25: 639-46.
    • (2008) Pharm Res , vol.25 , pp. 639-646
    • Sato, M.1    Iwanaga, T.2    Mamada, H.3
  • 29
    • 0037213731 scopus 로고    scopus 로고
    • Urate transport viahuman PAH transporter hOAT1 and its gene structure
    • Ichida K, Hosoyamada M, Kimura H, et al. Urate transport viahuman PAH transporter hOAT1 and its gene structure. Kidney Int 2003; 63: 143-55.
    • (2003) Kidney Int , vol.63 , pp. 143-155
    • Ichida, K.1    Hosoyamada, M.2    Kimura, H.3
  • 30
    • 43049121374 scopus 로고    scopus 로고
    • Multiple organic anion transporterscontribute to net renal excretion of uric acid
    • Eraly SA, Vallon V, Rieg T, et al. Multiple organic anion transporterscontribute to net renal excretion of uric acid. Physiol Genomics 2008; 33: 180-92.
    • (2008) Physiol Genomics , vol.33 , pp. 180-192
    • Eraly, S.A.1    Vallon, V.2    Rieg, T.3
  • 31
    • 77649212118 scopus 로고    scopus 로고
    • Renal secretion of uric acid by organic anion transporter 2(OAT2/SLC22A7) in human
    • Sato M, Mamada H, Anzai N, Shirasaka Y, Nakanishi T, Tamai I. Renal secretion of uric acid by organic anion transporter 2(OAT2/SLC22A7) in human. Biol Pharm Bull 2010; 33: 498-503.
    • (2010) Biol Pharm Bull , vol.33 , pp. 498-503
    • Sato, M.1    Mamada, H.2    Anzai, N.3    Shirasaka, Y.4    Nakanishi, T.5    Tamai, I.6
  • 33
    • 12144257103 scopus 로고    scopus 로고
    • Humanorganic anion transporter MRP4 (ABCC4) is an efflux pump forthe purine end metabolite urate with multiple allosteric substratebinding sites
    • van Aubel, RA, Smeets PH, van den Heuvel JJ, Russel FG. Humanorganic anion transporter MRP4 (ABCC4) is an efflux pump forthe purine end metabolite urate with multiple allosteric substratebinding sites. Am J Physiol Renal Physiol 2005; 288: F327-33.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • van Aubel, R.A.1    Smeets, P.H.2    van den Heuvel, J.J.3    Russel, F.G.4
  • 34
    • 56749156484 scopus 로고    scopus 로고
    • Effect of hypouricaemic and hyperuricaemic drugs on therenal urate efflux transporter, multidrug resistance protein 4
    • El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG. Effect of hypouricaemic and hyperuricaemic drugs on therenal urate efflux transporter, multidrug resistance protein 4. Br JPharmacol 2008; 155: 1066-75.
    • (2008) Br J Pharmacol , vol.155 , pp. 1066-1075
    • El-Sheikh, A.A.1    van den Heuvel, J.J.2    Koenderink, J.B.3    Russel, F.G.4
  • 35
    • 57049083981 scopus 로고    scopus 로고
    • Association of three geneticloci with uric acid concentration and risk of gout: A genome-wideassociation study
    • Dehghan A, Köttgen A, Yang Q, et al. Association of three geneticloci with uric acid concentration and risk of gout: a genome-wideassociation study. Lancet 2008; 372: 1953-61.
    • (2008) Lancet , vol.372 , pp. 1953-1961
    • Dehghan, A.1    Köttgen, A.2    Yang, Q.3
  • 37
    • 70349088929 scopus 로고    scopus 로고
    • Human ABC transporter ABCG2 incancer chemotherapy and pharmacogenomics
    • Ishikawa T, Nakagawa H. Human ABC transporter ABCG2 incancer chemotherapy and pharmacogenomics. J Exp Ther Oncol 2009; 8: 5-24.
    • (2009) J Exp Ther Oncol , vol.8 , pp. 5-24
    • Ishikawa, T.1    Nakagawa, H.2
  • 38
    • 0034595094 scopus 로고    scopus 로고
    • P-aminohippuric acidtransport at renal apical membrane mediated by human inorganicphosphate transporter NPT1
    • Uchino H, Tamai I, Yamashita K, et al. p-aminohippuric acidtransport at renal apical membrane mediated by human inorganicphosphate transporter NPT1. Biochem Biophys Res Commun 2000; 270: 254-9.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 254-259
    • Uchino, H.1    Tamai, I.2    Yamashita, K.3
  • 39
    • 77951537880 scopus 로고    scopus 로고
    • Sodium-dependent phosphatecotransporter type 1 (NPT1) sequence polymorphisms inmale patients with gout
    • Urano W, Taniguchi A, Anzai N, et al. Sodium-dependent phosphatecotransporter type 1 (NPT1) sequence polymorphisms inmale patients with gout. Ann Rheum Dis 2010; 69: 932-3.
    • (2010) Ann Rheum Dis , vol.69 , pp. 932-933
    • Urano, W.1    Taniguchi, A.2    Anzai, N.3
  • 40
    • 34848852618 scopus 로고    scopus 로고
    • Drug discovery for hyperuricemia
    • Anzai N, Endou H. Drug discovery for hyperuricemia. Expert OpinDrug Discov 2007; 2: 1251-61.
    • (2007) Expert Opin Drug Discov , vol.2 , pp. 1251-1261
    • Anzai, N.1    Endou, H.2
  • 41
    • 1842778906 scopus 로고    scopus 로고
    • Functional identificationof SLC5A8, a tumor suppressor down-regulated in colon cancer,as a Na(+)-coupled transporter for short-chain fatty acids
    • Miyauchi S, Gopal E, Fei YJ, Ganapathy V. Functional identificationof SLC5A8, a tumor suppressor down-regulated in colon cancer,as a Na(+)-coupled transporter for short-chain fatty acids. JBiol Chem 2004; 279: 13293-6.
    • (2004) J Biol Chem , vol.279 , pp. 13293-13296
    • Miyauchi, S.1    Gopal, E.2    Fei, Y.J.3    Ganapathy, V.4
  • 43
    • 33748755827 scopus 로고    scopus 로고
    • C/ebpdelta Null mouseas a model for the double knock-out of slc5a8 and slc5a12 inkidney
    • Thangaraju M, Ananth S, Martin PM, et al. c/ebpdelta Null mouseas a model for the double knock-out of slc5a8 and slc5a12 inkidney. J Biol Chem 2006; 281: 26769-73.
    • (2006) J Biol Chem , vol.281 , pp. 26769-26773
    • Thangaraju, M.1    Ananth, S.2    Martin, P.M.3
  • 44
    • 67651056502 scopus 로고    scopus 로고
    • Meta-Analysis of 28,141individuals identifies commonvariants within five new loci thatinfluence uric acid concentrations
    • Kolz M, Johnson T, Sanna S, et al. Meta-Analysis of 28,141individuals identifies commonvariants within five new loci thatinfluence uric acid concentrations. Plos Genet 2009; 5: 1-10.
    • (2009) Plos Genet , vol.5 , pp. 1-10
    • Kolz, M.1    Johnson, T.2    Sanna, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.