Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity

Journal of Cellular Physiology

Volumn 226, Issue 7, 2011, Pages 1953-1959

  Ponce, Daniela P ^a   Maturana, Jose L ^a   Cabello, Pablo ^a   Yefi, Roger ^a   Niechi, Ignacio ^a   Silva, Eduardo ^a   Armisen, Ricardo ^a   Galindo, Mario ^a   Antonelli, Marcelo ^a   Tapia, Julio C ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASEIN KINASE II; CASEIN KINASE IIALPHA; PROTEIN KINASE B; SURVIVIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CELL VIABILITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION; UPREGULATION;

BETA CATENIN; CASEIN KINASE II; CELL SURVIVAL; HEK293 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; SERINE; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 79952296431     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22527     Document Type: Article

References (26)

1. Altieri DC. 2004. Molecular circuits of apoptosis regulation and cell division control: The survivin paradigm. J Cell Biochem 92:656-663.
2. Beachy PA, Karhadkar SS, Berman DM. 2004. Tissue repair and stem cell renewal in carcinogenesis. Nature 432:324-331.
3. Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna LA, Ruzzene M. 2005. Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ 12:668-677.
4. Fabbro M, Henderson BR. 2003. Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res 282:59-69.
5. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. 2007. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 282:11221-11229.
6. Guerra B. 2006. Protein kinase CK2 subunits are positive regulators of AKT kinase. Int J Oncol 28:685-693.
7. Hanada M, Feng J, Hemmings BA. 2004. Structure, regulation and function of PKB/AKT-A major therapeutic target. Biochim Biophys Acta 1697:3-16.
8. Heeg-Truesdell E, LaBonne C. 2006. Wnt signaling: A shaggy dogma tale. Curr Biol 16:R62-R64.
9. Kerbel RS. 2008. Tumor angiogenesis. N Engl J Med 358:2039-2049.
10. Kimelman D, Xu W. 2006. Beta-catenin destruction complex: Insights and questions from a structural perspective. Oncogene 25:7482-7491.
11. Li D, Dobrowolska G, Aicher LD, Chen M, Wright JH, Drueckes P, Dunphy EL, Munar ES, Krebs EG. 1999. Expression of the casein kinase 2 subunits in Chinese hamster ovary and 3T3 L1 cells provides information on the role of the enzyme in cell proliferation and the cell cycle. J Biol Chem 274:32988-32996.
12. Litchfield DW. 2003. Protein kinase CK2: Structure, regulation and role in cellular decisions of life and death. Biochem J 369:1-15.
13. Nagy JA, Dvorak AM, Dvorak HF. 2007. VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol 2:251-275.
14. Neri D, Bicknell R. 2005. Tumour vascular targeting. Nat Rev Cancer 5:436-446.
15. Nicholson KM, Anderson NG. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14:381-395.
16. Olsen BB, Bjorling-Poulsen M, Guerra B. 2007. Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: A study on its mechanism of action. Int J Biochem Cell Biol 39:227-237.
17. Pinna LA. 2002. Protein kinase CK2: A challenge to canons. J Cell Sci 115:3873-3878.
18. Rodriguez DA, Tapia JC, Fernandez JG, Torres VA, Munoz N, Galleguillos D, Leyton L, Quest AF. 2009. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell 20:2297-2310.
19. Seldin DC, Landesman-Bollag E, Farago M, Currier N, Lou D, Dominguez I. 2005. CK2 as a positive regulator of Wnt signalling and tumourigenesis. Mol Cell Biochem 274:63-67.
20. Song DH, Sussman DJ, Seldin DC. 2000. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. J Biol Chem 275:23790-23797.
21. Song DH, Dominguez I, Mizuno J, Kaut M, Mohr SC, Seldin DC. 2003. CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem 278:24018-24025.
22. Tapia J, Jacob G, Allende CC, Allende JE. 2002. Role of the carboxyl terminus on the catalytic activity of protein kinase CK2alpha subunit. FEBS Lett 531:363-368.
23. Tapia JC, Torres VA, Rodriguez DA, Leyton L, Quest AF. 2006. Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription. Proc Natl Acad Sci USA 103:15079-15084.
24. Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. 2004. Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci USA 101:15370-15375.
25. Votin V, Nelson WJ, Barth AI. 2005. Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J Cell Sci 118:5699-5708.
26. Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC. 2000. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem 275:8027-8031.