Depletion of mitochondrial acyl carrier protein in bloodstream-form trypanosoma brucei causes a kinetoplast segregation defect

Eukaryotic Cell

Volumn 10, Issue 3, 2011, Pages 286-292

  Clayton, April M ^a,d   Guler, Jennifer L ^a,e   Povelones, Megan L ^a,f   Gluenz, Eva ^b   Gull, Keith ^b   Smith, Terry K ^c   Jensen, Robert E ^a   Englund, Paul T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN; KINETOPLAST DNA; MITOCHONDRIAL PROTEIN; PROTOZOAL PROTEIN;

AFRICAN TRYPANOSOMIASIS; ARTICLE; BLOOD; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; PARASITOLOGY; TRYPANOSOMA BRUCEI;

ACYL CARRIER PROTEIN; BLOOD; DNA, KINETOPLAST; HUMANS; MITOCHONDRIAL PROTEINS; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EUKARYOTA; TRYPANOSOMA BRUCEI;

EID: 79952286710     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00290-10     Document Type: Article

References (29)

1. Autio, K. J., J. L. Guler, A. J. Kastaniotis, P. T. Englund, and J. K. Hiltunen. 2008. The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei. FEBS Lett. 582: 729-733.
2. Baines, A., and K. Gull. 2008. WCB is a C2 domain protein defining the plasma membrane-sub-pellicular microtubule corset of kinetoplastid parasites. Protist 159: 115-125.
3. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
4. Chen, J., P. T. Englund, and N. R. Cozzarelli. 1995. Changes in network topology during the replication of kinetoplast DNA. EMBO J. 14: 6339-6347.
5. Downey, N., J. C. Hines, K. M. Sinha, and D. S. Ray. 2005. Mitochondrial DNA ligases of Trypanosoma brucei. Eukaryot. Cell 4: 765-774.
6. Drew, M. E., and P. T. Englund. 2001. Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates. J. Cell Biol. 153: 735-744.
7. Ferguson, M. L., A. F. Torri, D. Perez-Morga, D. C. Ward, and P. T. Englund. 1994. Kinetoplast DNA replication: mechanistic differences between Trypanosoma brucei and Crithidia fasciculata. J. Cell Biol. 126: 631-639.
8. Fridberg, A., et al. 2008. Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. J. Cell Sci. 121: 522-535.
9. Gluenz, E., M. K. Shaw, and K. Gull. 2007. Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast. Mol. Microbiol. 64: 1529-1539.
10. Guler, J. L., E. Kriegova, T. K. Smith, J. Lukes, and P. T. Englund. 2008. Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei. Mol. Microbiol. 67: 1125-1142.
11. Hirumi, H., and K. Hirumi. 1989. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol. 75: 985-989.
12. Klingbeil, M. M., S. A. Motyka, and P. T. Englund. 2002. Multiple mitochondrial DNA polymerases in Trypanosoma brucei. Mol. Cell 10: 175-186.
13. Lee, S. H., J. L. Stephens, and P. T. Englund. 2007. A fatty-acid synthesis mechanism specialized for parasitism. Nat. Rev. Microbiol. 5: 287-297.
14. Lee, S. H., J. L. Stephens, K. S. Paul, and P. T. Englund. 2006. Fatty acid synthesis by elongases in trypanosomes. Cell 126: 691-699.
15. Li, Z., M. E. Lindsay, S. A. Motyka, P. T. Englund, and C. C. Wang. 2008. Identification of a bacterial-like HslVU protease in the mitochondria of Trypanosoma brucei and its role in mitochondrial DNA replication. PLoS Pathog. 4:e1000048.
16. Lindsay, M. E., E. Gluenz, K. Gull, and P. T. Englund. 2008. A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology. Mol. Microbiol. 70: 1465-1476.
17. Liu, B., Y. Liu, S. A. Motyka, E. E. C. Agbo, and P. T. Englund. 2005. Fellowship of the rings: the replication of kinetoplast DNA. Trends Parasitol. 21: 363-369.
18. Miyahira, Y., and J. A. Dvorak. 1994. Kinetoplastidae display naturally occurring ancillary DNA-containing structures. Mol. Biochem. Parasitol. 65: 339-349.
19. Ogbadoyi, E. O., D. R. Robinson, and K. Gull. 2003. A high-order transmembrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes. Mol. Biol. Cell 14: 1769-1779.
20. Pérez-Morga, D., and P. T. Englund. 1993. The attachment of minicircles to kinetoplast DNA networks during replication. Cell 74: 703-711.
21. Pérez-Morga, D. L., and P. T. Englund. 1993. Microtechnique for electron microscopy of DNA. Nucleic Acids Res. 21: 1328-1329.
22. Richmond, G. S., et al. 2010. Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei. Parasitology 137: 1357-1392.
23. Robinson, D. R., and K. Gull. 1991. Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle. Nature 352: 731-733.
24. Scocca, J. R., and T. A. Shapiro. 2008. A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes. Mol. Microbiol. 67: 820-829.
25. Shlomai, J. 2004. The structure and replication of kinetoplast DNA. Curr. Mol. Med. 4: 623-647.
26. Stephens, J. L., S. H. Lee, K. S. Paul, and P. T. Englund. 2007. Mitochondrial fatty acid synthesis in Trypanosoma brucei. J. Biol. Chem. 282: 4427-4436.
27. Sutterwala, S. S., et al. 2008. Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol. Microbiol. 70: 281-296.
28. Wang, Z., and P. T. Englund. 2001. RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA. EMBO J. 20: 4674-4683.
29. Zhao, Z., M. E. Lindsay, A. Roy Chowdhury, D. R. Robinson, and P. T. Englund. 2008. p166, a link between the trypanosome mitochondrial DNA and flagellum, mediates genome segregation. EMBO J. 27: 143-154.