Evaluation of HLA-G5 Plasmatic Levels During Pregnancy and Relationship with the 14-bp Polymorphism

American Journal of Reproductive Immunology

Volumn 64, Issue 5, 2010, Pages 367-374

  Gonzalez, Alvaro ^a   Alegre, Estibaliz ^a   Torres, Maria I ^b   Díaz Lagares, Angel ^a   Lorite, Pedro ^b   Palomeque, Teresa ^b   Arroyo, Ainhoa ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

HLA G; Miscarriage; Polymorphism; Pregnancy

Indexed keywords

DNA; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA G ANTIGEN; HLA-G ANTIGEN; ISOPROTEIN;

ADULT; ARTICLE; BLOOD; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; HUMAN; NONPARAMETRIC TEST; POLYMERASE CHAIN REACTION; PREGNANCY; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC VARIATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREGNANCY; PROTEIN ISOFORMS; STATISTICS, NONPARAMETRIC;

EID: 79952276982     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2010.00855.x     Document Type: Article

References (51)

1. Hunt JS, Langat DL: HLA-G: a human pregnancy-related immunomodulator. Curr Opin Pharmacol 2009; 9:462-469.
2. Carosella ED, Moreau P, LeMaoult J, Rouas-Freiss N: HLA-G: from biology to clinical benefits. Trends Immunol 2008; 29:125-133.
3. Ishitani A, Geraghty D: Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc Natl Acad Sci USA 1992; 89:3947-3951.
4. Hviid TVF: HLA-G in human reproduction: aspects of genetics, function and pregnancy complications. Hum Reprod Update 2005; 12:209-232.
5. Díaz-Lagares Á, Alegre E, Gonzalez Á: Detection of 3-nitrotyrosine-modified human leukocyte antigen-G in biological fluids. Hum Immunol 2009; 70:976-980.
6. Park GM, Lee S, Park B, Kim E, Shin J, Cho K, Ahn K: Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis. Biochem Biophys Res Commun 2004; 313:606-611.
7. Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R: A class I antigen, HLA-G, expressed in human trophoblasts. Science 1990; 248:220-223.
8. Houlihan J, Biro P, Harper H, Jenkinson H, Holmes C: The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G. J Immunol 1995; 154:5665-5674.
9. Blaschitz A, Lenfant F, Mallet V, Hartmann M, Bensussan A, Geraghty DE, Le Bouteiller P, Dohr G: Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G. Eur J Immunol 1997; 27:3380-3388.
10. Gonzalez A, LeMaoult J, Lopez A, Alegre E, Caumartin J, Le Rond S, Daouya M, Moreau P, Carosella ED: Linking two immuno-suppressive molecules: indoleamine 2, 3 dioxygenase can modify HLA-G cell-surface expression. Biol Reprod 2005; 73:571-578.
11. Urosevic M, Dummer R: Human leukocyte antigen-G and cancer immunoediting. Cancer Res 2008; 68:627-630.
12. Luque J, Torres MI, Aumente MD, Marin J, Garcia-Jurado G, Gonzalez R, Pascual D, Guerra N, Lopez-Rubio F, Alvarez-Lopez MR: Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy. Hum Immunol 2006; 67:257-263.
13. Le Gal F-A, Riteau B, Sedlik C, Khalil-Daher I, Menier C, Dausset J, Guillet J-G, Carosella ED, Rouas-Freiss N: HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes. Int Immunol 1999; 11:1351-1356.
14. Rouas-Freiss N, Goncalves RM-B, Menier C, Dausset J, Carosella ED: Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. Proc Natl Acad Sci USA 1997; 94:11520-11525.
15. Steinborn A, Varkonyi T, Scharf A, Bahlmann F, Klee A, Sohn C: Early detection of decreased soluble HLA-G levels in the maternal circulation predicts the occurrence of preeclampsia and intrauterine growth retardation during further course of pregnancy. Am J Reprod Immunol 2007; 57:277-286.
16. Alegre E, Diaz-Lagares A, LeMaoult J, Lopez-Moratalla N, Carosella ED, Gonzalez A: Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy. Hum Immunol 2007; 68:661-667.
17. Yie SM, Li LH, Li YM, Librach C: HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia. Am J Obstet Gynecol 2004; 191:525-529.
18. Solier C, Aguerre-Girr M, Lenfant F, Campan A, Berrebi A, Rebmann V, Grosse-Wilde H, Le Bouteiller P: Secretion of pro-apoptotic intron 4-retaining soluble HLA-G1 by human villous trophoblast. Eur J Immunol 2002; 32:3576-3586.
19. Morales PJ, Pace JL, Platt JS, Langat DK, Hunt JS: Synthesis of beta(2)-microglobulin-free, disulphide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells. Immunology 2007; 122:179-188.
20. Blaschitz A, Juch H, Volz A, Hutter H, Daxboeck C, Desoye G, Dohr G: The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms. Mol Hum Reprod 2005; 8:8.
21. Yao YQ, Barlow DH, Sargent IL: Differential expression of alternatively spliced transcripts of HLA-G in human preimplantation embryos and inner cell masses. J Immunol 2005; 175:8379-8385.
22. Rizzo R, Andersen AS, Lassen MR, Sørensen HC, Bergholt T, Larsen MH, Melchiorri L, Stignani M, Baricordi OR, Hviid TVF: Soluble human leukocyte antigen-G isoforms in maternal plasma in early and late pregnancy. Am J Reprod Immunol 2009; 62:320-338.
23. Lajoie J, Boivin A-A, Jeanneau A, Faucher M-C, Roger M: Identification of six new HLA-G alleles with non-coding DNA base changes. Tissue Antigens 2009; 73:379-380.
24. Harrison GA, Humphrey KE, Jakobsen IB, Cooper DW: A 14bp deletion polymorphism in the HLA-G gene. Hum Mol Genet 1993; 2:2200.
25. Hiby SE, King A, Sharkey A, Loke YW: Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo. Tissue Antigens 1999; 53:1-13.
26. Rousseau P, Le Discorde M, Mouillot G, Marcou C, Carosella ED, Moreau P: The 14bp Deletion-Insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol 2003; 64:1005-1010.
27. Hviid TV, Hylenius S, Rorbye C, Nielsen LG: HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 2003; 55:63-79.
28. Hviid TV, Rizzo R, Christiansen OB, Melchiorri L, Lindhard A, Baricordi OR: HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. Immunogenetics 2004; 56:135-141.
29. Yan W-H, Lin A, Li M, Xu H-H, Zhang Z-P, Wang X-X: Analysis of the 14bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations. Tissue Antigens 2008; 71:227-233.
30. Larsen MH, Hviid TVF: Human leukocyte antigen-G polymorphism in relation to expression, function, and disease. Hum Immunol 2009; 70:1026-1034.
31. Pfeiffer KA, Fimmers R, Engels G, Van Der Ven H, Van Der Ven K: The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion. Mol Hum Reprod 2001; 7:373-378.
32. Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB: HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 2002; 60:122-132.
33. Larsen MH, Hylenius S, Andersen A-MN, Hviid TVF: The 3′-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited. Tissue Antigens 2010; 75:253-261.
34. Crispim JC, Duarte RA, Soares CP, Costa R, Silva JS, Mendes-Junior CT, Wastowski IJ, Faggioni LP, Saber LT, Donadi EA: Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection. Transpl Immunol 2008; 18:361-367.
35. Torres MI, Luque J, Lorite P, Isla-Tejera B, Palomeque T, Aumente MD, Arizon J, Peña J: 14-Base pair polymorphism of human leukocyte antigen-G as genetic determinant in heart transplantation and cyclosporine therapy monitoring. Hum Immunol 2009; 70:830-835.
36. Glas J, Torok HP, Tonenchi L, Wetzke M, Beynon V, Teshome MY, Cotofana S, Schiemann U, Griga T, Klein W, Epplen JT, Folwaczny C, Folwaczny M, Mussack T, Weiss EH: The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. Int Immunol 2007; 19:621-626.
37. Gazit E, Slomov Y, Goldberg I, Brenner S, Loewenthal R: HLA-G is associated with pemphigus vulgaris in Jewish patients. Hum Immunol 2004; 65:39-46.
38. Rebmann V, Lemaoult J, Rouas-Freiss N, Carosella ED, Grosse-Wilde H: Report of the Wet-Workshop for Quantification of Soluble HLA-G in Essen, 2004. Hum Immunol 2005; 66:853-863.
39. Lopez AS, Alegre E, LeMaoult J, Carosella E, Gonzalez A: Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells. Mol Immunol 2006; 43:2151-2160.
40. Tripathi P, Abbas A, Naik S, Agrawal S: Role of 14-bp deletion in the HLA-G gene in the maintenance of pregnancy. Tissue Antigens 2004; 64:706-710.
41. Kahn-Perles B, Boyer C, Arnold B, Sanderson A, Ferrier P, Lemonnier F: Acquisition of HLA class I W6/32 defined antigenic determinant by heavy chains from different species following association with bovine beta 2- microglobulin. J Immunol 1987; 138:2190-2196.
42. Carosella ED, Favier B, Rouas-Freiss N, Moreau P, LeMaoult J: Beyond the increasing complexity of the immunomodulatory HLA-G molecule. Blood 2008; 111:4862-4870.
43. Rebmann V, LeMaoult J, Rouas-Freiss N, Carosella ED, Grosse-Wilde H: Quantification and identification of soluble HLA-G isoforms. Tissue Antigens 2007; 69:143-149.
44. Rizzo R, Fuzzi B, Stignani M, Criscuoli L, Melchiorri L, Dabizzi S, Campioni D, Lanza F, Marzola A, Branconi F, Noci I, Baricordi OR: Soluble HLA-G molecules in follicular fluid: a tool for oocyte selection in IVF? J Reprod Immunol 2007; 74:133-142.
45. Rebmann V, Busemann A, Lindemann M, Grosse-Wilde H: Detection of HLA-G5 secreting cells. Hum Immunol 2003; 64:1017-1024.
46. Le Friec G, Gros F, Sebti Y, Guilloux V, Pangault C, Fauchet R, Amiot L: Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA-G molecules. J Leukoc Biol 2004; 76:1125-1133.
47. Roman A, Rodriguez M, Herraiz MA, Jorda J, Cervera I, Penaloza J, Vidart JA, Martinez-Laso J: Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and plasmacytoid dendritic cells isolated from umbilical cord blood. Hum Immunol 2009; 70:104-109.
48. Rizzo R, Hviid TV, Stignani M, Balboni A, Grappa MT, Melchiorri L, Baricordi OR: The HLA-G genotype is associated with IL-10 levels in activated PBMCs. Immunogenetics 2005; 57:172-181.
49. Chen XY, Yan WH, Lin A, Xu HH, Zhang JG, Wang XX: The 14bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma. Tissue Antigens 2008; 72:335-341.
50. Rudstein-Svetlicky N, Loewenthal R, Horejsi V, Gazit E: HLA-G levels in serum and plasma. Tissue Antigens 2006; 67:111-116.
51. Ober C, Billstrand C, Kuldanek S, Tan Z: The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells. Hum Reprod 2006; 21:1743-1748.