Advances in the diagnosis and management of central venous access device infections in children

Advances in Experimental Medicine and Biology

Volumn 697, Issue , 2011, Pages 91-106

  Bowen, Asha ^c   Carapetis, Jonathan ^a,b  

^a MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^b CHARLES DARWIN UNIVERSITY   (Australia)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMIKACIN; AMPHOTERICIN B; AMPICILLIN; ANTIBIOTIC AGENT; CEFTAZIDIME; CITRIC ACID; EDETIC ACID; HEPARIN; HYDROCHLORIC ACID; LINEZOLID; TAUROLIDINE CITRATE; TEICOPLANIN; UNCLASSIFIED DRUG; UROKINASE; VANCOMYCIN;

ARTICLE; BACTERIUM CONTAMINATION; BACTERIUM IDENTIFICATION; BLOOD CULTURE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CATHETER INFECTION; CENTRAL VENOUS CATHETER; CHILD; COLONY FORMING UNIT; DEVICE INFECTION; DEVICE REMOVAL; DISEASE ASSOCIATION; DRUG CHOICE; DRUG POTENTIATION; ENTEROBACTER; ESCHERICHIA COLI; HUMAN; INFECTION COMPLICATION; INFECTION PREVENTION; INFECTION RISK; INTERMETHOD COMPARISON; KLEBSIELLA; MEDICAL DECISION MAKING; MOLECULAR DIAGNOSIS; MOLECULAR PATHOLOGY; NONHUMAN; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUALITY CONTROL; RISK ASSESSMENT; RISK FACTOR; SALVAGE THERAPY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; THROMBOSIS; THROMBOSIS PREVENTION; TREATMENT PLANNING; BACTERIAL INFECTION; CENTRAL VENOUS CATHETERIZATION; INFECTION CONTROL; METHODOLOGY; REVIEW;

BACTERIAL INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CHILD; HUMANS; INFECTION CONTROL;

EID: 79952276836     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7185-2_8     Document Type: Article

References (77)

1. Garcia-Teresa MA, Casado-Flores J, Delgado Dominguez MA, Roqueta-Mas J, Cambra- Lasaosa F, Concha-Torre A et al. Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study. Intensive Care Med. 2007 Mar;33(3):466-76.
2. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1994 May 25;271(20):1598-601.
3. Smith MJ. Catheter related blood stream infections in children. Am J Infect Control. 2008; www.ajic.org.
4. McGee DC, Gould MK. Preventing complications of central venous catheterization. N Engl J Med. 2003 Mar 20;348(12):1123-33.
5. Abdul-Rauf A, Gauderer M, Chiarucci K, Berman B. Long-term central venous access in patients with sickle cell disease. Incidence of thrombotic and infectious complications. J Pediatr Hematol Oncol. 1995 Nov;17(4):342-5.
6. Tarantino MD, Lail A, Donfield SM, Lynn H, Peddle L, Hunsberger S et al. Surveillance of infectious complications associated with central venous access devices in children with haemophilia. Haemophilia. 2003 Sep;9(5):588-92.
7. Tobiansky R, Lui K, Dalton DM, Shaw P, Martin H, Isaacs D. Complications of central venous access devices in children with and without cancer. J Paediatr Child Health. 1997 Dec;33(6):509-14.
8. Dezfulian C, Lavelle J, Nallamothu BK, Kaufman SR, Saint S. Rates of infection for singlelumen versus multilumen central venous catheters: a meta-analysis. Crit Care Med. 2003 Sep;31(9):2385-90.
9. Broviac JW, Cole JJ, Scribner BH. A silicone rubber atrial catheter for prolonged parenteral alimentation. Surg Gynecol Obstet. 1973 Apr;136(4):602-6.
10. Murai DT. Are femoral Broviac catheters effective and safe? A prospective comparison of femoral and jugular venous broviac catheters in newborn infants. Chest 2002 May;121(5):1527-30.
11. Bouza E, Burillo A, Munoz P. Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect. 2002 May;8(5):265-74.
12. Donlan RM. Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis. 2001 Oct 15;33(8):1387-92.
13. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002 Apr;15(2):167-93.
14. Ceri H, Olson ME, Stremick C, Read RR, Morck D, Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol. 1999 June;37(6):1771-6.
15. Curtin J, Cormican M, Fleming G, Keelehan J, Colleran E. Linezolid compared with eperezolid, vancomycin, and gentamicin in an in vitro model of antimicrobial lock therapy for Staphylococcus epidermidis central venous catheter-related biofilm infections. Antimicrob Agents Chemother. 2003 Oct;47(10):3145-8.
16. Wisplinghoff H, Seifert H, Tallent SM, Bischoff T, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. Pediatr Infect Dis J. 2003 Aug;22(8):686-91.
17. Rijnders BJ, Van WE, Vandecasteele SJ, Stas M, Peetermans WE. Treatment of longterm intravascular catheter-related bacteraemia with antibiotic lock: randomized, placebocontrolled trial. J Antimicrob Chemother. 2005 Jan;55(1):90-4.
18. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG et al. Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disease Control and Prevention. US Pediatr. 2002 Nov;110(5):e51.
19. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis. 2007 Oct;7(10):645-57.
20. Safdar N, Kluger DM, Maki DG. A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, noncuffed central venous catheters: implications for preventive strategies. Medicine (Baltimore). 2002 Nov;81(6):466-79.
21. Sohn AH, Garrett DO, Sinkowitz-Cochran RL, Grohskopf LA, Levine GL, Stover BH et al. Prevalence of nosocomial infections in neonatal intensive care unit patients: Results from the first national point-prevalence survey. J Pediatr. 2001 Dec;139(6):821-7.
22. Randolph AG, Brun-Buisson C, Goldmann D. Identification of central venous catheter-related infections in infants and children. Pediatr Crit Care Med. 2005 May;6(3 Suppl):S19-S24.
23. Odetola FO, Moler FW, Dechert RE, VanDerElzen K, Chenoweth C. Nosocomial catheterrelated bloodstream infections in a pediatric intensive care unit: risk and rates associated with various intravascular technologies. Pediatr Crit Care Med. 2003 Oct;4(4):432-6.
24. Adler A, Yaniv I, Solter E, Freud E, Samra Z, Stein J et al. Catheter-associated bloodstream infections in pediatric hematology-oncology patients: factors associated with catheter removal and recurrence. J Pediatr Hematol Oncol. 2006 Jan;28(1):23-8.
25. Simon A, Bode U, Beutel K. Diagnosis and treatment of catheter-related infections in paediatric oncology: an update. Clin Microbiol Infect. 2006 July;12(7):606-20.
26. Colomb V, Fabeiro M, Dabbas M, Goulet O, Merckx J, Ricour C. Central venous catheterrelated infections in children on long-term home parenteral nutrition: incidence and risk factors. Clin Nutr. 2000 Oct;19(5):355-9.
27. Beghetto MG, Victorino J, Teixeira L, de Azevedo MJ. Parenteral nutrition as a risk factor for central venous catheter-related infection. JPEN J Parenter Enteral Nutr. 2005 Sep;29(5): 367-73.
28. Goldstein SL, Macierowski CT, Jabs K. Hemodialysis catheter survival and complications in children and adolescents. Pediatr Nephrol. 1997 Feb;11(1):74-7.
29. Paglialonga F, Esposito S, Edefonti A, Principi N. Catheter-related infections in children treated with hemodialysis. Pediatr Nephrol. 2004 Dec;19(12):1324-33.
30. Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin Proc. 2006 Sep;81(9):1159-71.
31. Randolph AG, Cook DJ, Gonzales CA, Brun-Buisson C. Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. Crit Care Med. 1998 Aug;26(8):1452-7.
32. Nahum E, Levy I, Katz J, Samra Z, Ashkenazi S, Ben-Ari J et al. Efficacy of subcutaneous tunneling for prevention of bacterial colonization of femoral central venous catheters in critically ill children. Pediatr Infect Dis J. 2002 Nov;21(11):1000-4.
33. Kline AM. Pediatric catheter-related bloodstream infections: latest strategies to decrease risk. AACN Clin Issues. 2005 Apr;16(2):185-98.
34. Mermel LA, Farr BM, Sherertz RJ, Raad II, O'Grady N, Harris JS et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis. 2001 May 1;32(9):1249-72.
35. Flynn PM, Shenep JL, Stokes DC, Barrett FF. In situ management of confirmed central venous catheter-related bacteremia. Pediatr Infect Dis J. 1987 Aug;6(8):729-34.
36. Abdelkefi A, Achour W, Torjman L, Ben OT, Ladeb S, Lakhal A et al. Detection of catheterrelated bloodstream infections by the Gram stain-acridine orange leukocyte cytospin test in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2006 Mar;37(6): 595-9.
37. Widmer AF, Nettleman M, Flint K,Wenzel RP. The clinical impact of culturing central venous catheters. A prospective study. Arch Intern Med. 1992 Jun;152(6):1299-302.
38. Farina C, Bonanomi E, Benetti G, Fumagalli R, Goglio A. Acridine orange leukocyte cytospin test for central venous catheter-related bloodstream infection: a pediatric experience. Diagn Microbiol Infect Dis. 2005 Aug;52(4):337-9.
39. Millar MR, Johnson G,WilksM, Skinner R, Stoneham S, Pizer B et al. Molecular diagnosis of vascular access device-associated infection in children being treated for cancer or leukaemia. Clin Microbiol Infect. 2008 Mar;14(3):213-20.
40. Abdelkefi A, Achour W, Ben OT, Torjman L, Ladeb S, Lakhal A et al. Difference in time to positivity is useful for the diagnosis of catheter-related bloodstream infection in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2005 Feb;35(4):397-401.
41. Acuna M, O'Ryan M, Cofre J, Alvarez I, Benadof D, Rodriguez P et al. Differential time to positivity and quantitative cultures for noninvasive diagnosis of catheter-related blood stream infection in children. Pediatr Infect Dis J. 2008 Aug;27(8):681-5.
42. Flynn PM, Shenep JL, Barrett FF. Differential quantitation with a commercial blood culture tube for diagnosis of catheter-related infection. J Clin Microbiol. 1988 May;26(5): 1045-6.
43. Gaur AH, Flynn PM, Giannini MA, Shenep JL, Hayden RT. Difference in time to detection: a simple method to differentiate catheter-related from non-catheter-related bloodstream infection in immunocompromised pediatric patients. Clin Infect Dis. 2003 Aug 15;37(4): 469-75.
44. Germanakis I, Christidou A, Galanakis E, Kyriakakis I, Tselentis Y, Kalmanti M. Qualitative versus quantitative blood cultures in the diagnosis of catheter-related bloodstream infections in children with malignancy. Pediatr Blood Cancer. 2005 Dec;45(7):939-44.
45. Germanakis J, Stiakaki E, Galanakis E, Christidou A, Neonakis J, Dimitriou H et al. Prognostic value of quantitative blood cultures for the outcome of central venous catheters in children. Scand J Infect Dis. 2002;34(9):680-2.
46. Guerti K, IevenM,Mahieu L. Diagnosis of catheter-related bloodstream infection in neonates: a study on the value of differential time to positivity of paired blood cultures. Pediatr Crit Care Med. 2007 Sep;8(5):470-5.
47. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for disease control and prevention. MMWR Recomm Rep. 2002 Aug 9;51(RR-10):1-29.
48. Crnich CJ, Maki DG. The promise of novel technology for the prevention of intravascular device-related bloodstream infection. II. Long-term devices. Clin Infect Dis. 2002 May 15;34(10):1362-8.
49. Crnich CJ, Maki DG. The promise of novel technology for the prevention of intravascular device-related bloodstream infection. I. Pathogenesis and short-term devices. Clin Infect Dis. 2002 May 1;34(9):1232-42.
50. Veenstra DL, Saint S, Sullivan SD. Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA. 1999 Aug 11;282(6):554-60.
51. Oncu S, Oncu S, Ozturk B, Kurt I, Sakarya S. Elimination of intraluminal colonization by antibiotic lock in catheters. Tohoku J Exp Med. 2004 May;203(1):1-8.
52. Carratala J. The antibiotic-lock technique for therapy of 'highly needed' infected catheters. Clin Microbiol Infect. 2002 May;8(5):282-9.
53. Lee JY, Ko KS, Peck KR, Oh WS, Song JH. In vitro evaluation of the antibiotic lock technique (ALT) for the treatment of catheter-related infections caused by staphylococci. J Antimicrob Chemother. 2006 Jun;57(6):1110-15.
54. Lee MY, Ko KS, Song JH, Peck KR. In vitro effectiveness of the antibiotic lock technique (ALT) for the treatment of catheter-related infections by Pseudomonas aeruginosa and Klebsiella pneumoniae. J Antimicrob Chemother. 2007 Oct;60(4):782-7.
55. Raad I, Hanna H, Jiang Y, Dvorak T, Reitzel R, Chaiban G et al. Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob Agents Chemother. 2007 May;51(5):1656-60.
56. Bestul MB, Vandenbussche HL. Antibiotic lock technique: review of the literature. Pharmacotherapy. 2005 Feb;25(2):211-27.
57. Segarra-Newnham M, Martin-Cooper EM. Antibiotic lock technique: a review of the literature. Ann Pharmacother. 2005 Feb;39(2):311-18.
58. Castagnola E, Moroni C, Gandullia P, Oddone M, Peri C, Casciaro R et al. Catheter lock and systemic infusion of linezolid for treatment of persistent Broviac catheterrelated staphylococcal bacteremia. Antimicrob Agents Chemother. 2006 Mar;50(3): 1120-1.
59. Fernandez-Hidalgo N, Almirante B, Calleja R, Ruiz I, Planes AM, Rodriguez D et al. Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study. J Antimicrob Chemother. 2006 Jun;57(6): 1172-80.
60. Guedon C, Nouvellon M, Lalaude O, Lerebours E. Efficacy of antibiotic-lock technique with teicoplanin in staphylococcus epidermidis catheter-related sepsis during long-term parenteral nutrition. JPEN J Parenter Enteral Nutr. 2002 Mar;26(2):109-13.
61. Viale P, Pagani L, Petrosillo N, Signorini L, Colombini P, Macri G et al. Antibiotic locktechnique for the treatment of catheter-related bloodstream infections. J Chemother. 2003 Apr;15(2):152-6.
62. Safdar N, Maki DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trials. Clin Infect Dis. 2006 Aug 15;43(4):474-84.
63. Cuntz D, Michaud L, Guimber D, Husson MO, Gottrand F, Turck D. Local antibiotic lock for the treatment of infections related to central catheters in parenteral nutrition in children. JPEN J Parenter Enteral Nutr. 2002 Mar;26(2):104-8.
64. Johnson DC, Johnson FL, Goldman S. Preliminary results treating persistent central venous catheter infections with the antibiotic lock technique in pediatric patients. Pediatr Infect Dis J. 1994 Oct;13(10):930-1.
65. Elwood RL, Spencer SE. Successful clearance of catheter-related bloodstream infection by antibiotic lock therapy using ampicillin. Ann Pharmacother. 2006 Feb;40(2):347-50.
66. Garland JS, Alex CP, Henrickson KJ, McAuliffe TL, Maki DG. A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trial. Pediatrics. 2005 Aug;116(2):e198-e205.
67. Chambers ST, Peddie B, Pithie A. Ethanol disinfection of plastic-adherent micro-organisms. J Hosp Infect. 2006 Jun;63(2):193-6.
68. Dannenberg C, Bierbach U, Rothe A, Beer J, Korholz D. Ethanol-lock technique in the treatment of bloodstream infections in pediatric oncology patients with broviac catheter. J Pediatr Hematol Oncol. 2003 Aug;25(8):616-21.
69. Onland W, Shin CE, Fustar S, Rushing T, Wong WY. Ethanol-lock technique for persistent bacteremia of long-term intravascular devices in pediatric patients. Arch Pediatr AdolescMed. 2006 Oct;160(10):1049-53.
70. Bowen A, Walls T, Day A, Jackson R, Russell S, Clarkson C, Palasanthiran P. Ethanol lock therapy as adjunctive management of central venous access device infections in total parenteral nutrition dependent children. Poster presented to the Australasian Society of Infectious Diseases conference, New South Wales, 25-29 March 2009.
71. Barbaric D, Curtin J, Pearson L, Shaw PJ. Role of hydrochloric acid in the treatment of central venous catheter infections in children with cancer. Cancer. 2004 Oct 15;101(8):1866-72.
72. Bradshaw JH, Puntis JW. Taurolidine and catheter-related bloodstream infection: a systematic review of the literature. J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):179-86.
73. Simon A, Ammann RA,Wiszniewsky G, Bode U, Fleischhack G, Besuden MM. Taurolidinecitrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infect Dis. 2008;8:102.
74. Jones GR, Konsler GK, Dunaway RP. Urokinase in the treatment of bacteremia and candidemia in patients with right atrial catheters. Am J Infect Control. 1996 Jun;24(3):160-6.
75. Simon A, Bode U, Lieber K, Beutel K, Fleischhack G. Review and update of the use of urokinase in the prevention and management of CVAD-related complications in pediatric oncology patients. Am J Infect Control. 2008 Feb;36(1):54-8.
76. Aquino VM, Sandler ES, Mustafa MM, Steele JW, Buchanan GR. A prospective doubleblind randomized trial of urokinase flushes to prevent bacteremia resulting from luminal colonization of subcutaneous central venous catheters. J Pediatr Hematol Oncol. 2002 Dec;24(9):710-13.
77. Dillon PW, Jones GR, Bagnall-Reeb HA, Buckley JD, Wiener ES, Haase GM. Prophylactic urokinase in the management of long-term venous access devices in children: a children's oncology group study. J Clin Oncol. 2004 Jul 1;22(13):2718-23.