An experimental study on the therapy of infantile hemangioma with recombinant interferon γ

Journal of Pediatric Surgery

Volumn 46, Issue 3, 2011, Pages 496-501

  Peng, Qiang ^a,b   Liu, Wenying ^a,c   Zhou, Fang ^a   Wang, Yuanxiang ^a   Ji, Yi ^c  

^a SICHUAN UNIVERSITY   (China)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

^c SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Hemangioma; Interferon; Nude mice; Study; Therapy

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; KI 67 ANTIGEN; MESSENGER RNA; RECOMBINANT GAMMA INTERFERON; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPILLARY HEMANGIOMA; CAPILLARY PROLIFERATION; CASE REPORT; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMPLANT; INFANT; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL DIVISION; FEMALE; HEMANGIOMA, CAPILLARY; HUMANS; IMMUNOLOGIC FACTORS; INFANT; INJECTIONS, SUBCUTANEOUS; INTERFERON-GAMMA, RECOMBINANT; KI-67 ANTIGEN; MICE; MICE, NUDE; NEOPLASM PROTEINS; RANDOM ALLOCATION; RECEPTORS, INTERFERON; RNA, MESSENGER; RNA, NEOPLASM; SKIN NEOPLASMS; SUBCUTANEOUS TISSUE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79952271041     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.09.056     Document Type: Article

References (19)

1. Peker E., Kirimi E., and Tuncer O. Brachial plexus paralysis due to giant cavernous hemangioma with Kasabach-Merritt syndrome: successful management with interferon alpha Platelets 20 2009 603 605
2. Lee L., Sudentas P., and Donohue B. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse model Genes Chromosomes Cancer 42 2005 213 227 (Pubitemid 40171186)
3. Peng Q., Liu W., and Tang Y. The establishment of the hemangioma model in nude mouse J Pediatr Surg 40 2005 1167 1172 (Pubitemid 40966670)
4. Zarem H.A., and Edgerton M.T. Induced resolution of cavernous hemangiomas following prednisolone therapy Plast Reconstr Surg 39 1967 76
5. Gottschling S., Schneider G., and Meyer S. Two infants with life-threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide Pediatr Blood Cancer 46 2006 239 242 (Pubitemid 43076076)
6. Jiménez H.E., Dueñas G.M.T., and Quintero C.J.L. Treatment with interferonalpha2b in children with life-threatening hemangiomas Dermatol Surg 34 2008 640 647
7. Garmendia G., Miranda N., and Borroso S. Regression of infancy hemangiomas with recombinant IFN-alpha 2b J Interferon Cytokine Res 21 2001 31 38 (Pubitemid 32106088)
8. Wananukul S., Nuchprayoon I., and Seksarn P. Treatment of Kasabach- Merritt syndrome: a stepwise regimen of prednisolone, dipyridamole, and interferon Int J Dermatol 42 2003 741 748 (Pubitemid 37160511)
9. Schaaf M.J., and Cidlowski J.A. AUUUA motifs in the 3′UTR of human glucocorticoid receptor alpha and beta mRNA destabilizes mRNA and decrease receptor protein expression Steroids 67 2002 627 636 (Pubitemid 34462990)
10. Chao Y.H., Liang D.C., and Chen S.H. Interferon-alpha for alarming hemangiomas in infants: experience of a single institution Pediatr Int 51 2009 469 473
11. Zhang Z.J., Muhr C., and Wang J.L. Interferon-alpha inhibits the DNA synthesis induced by PDGF and EGF in cultured meningioma cells Anticancer Res 16 1996 717 723 (Pubitemid 26182001)
12. White C.W., Sondheumer H.M., and Crouch E. Treatment of pneumonary hemangiomatosis with recombinant interferonα-2a N Engl J Med 320 1989 1197
13. Bielenberg D.R., Bucana C.D., and Sanchez R. Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta Int J Oncol 14 1999 401 408
14. Sgonc R., Fuerhapter C., and Boeck G. Induction of apoptosis in human dermal microvascular endothelial cells and infantile hemangiomas by interferon-alpha Int Arch Allergy Immunol 117 1998 209
15. Lindner D.J. Interferons as antiangiogenic agents Curr Oncol Rep 4 2002 510 514
16. Deiss L.P., Feinstein E., and Berissi H. Identification of a novel serine/threonine kinase and a novel 15 Kd protein as potential mediators of the gamma interferon-induced cell death Genes Dev 9 1995 15 30
17. Cohen O., Feinstein E., and Kimchi A. DAP-Kinase is a Ca2+/calmodulin dependent, cytoskeletal-associated protein kinase,with cell death-inducing functions that depend on its catalytic activity EMBO J 16 1997 998 1008 (Pubitemid 27113179)
18. Burch L.R., Scott M., and Pohler E. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1 J Mol Biol 337 2004 115 128 (Pubitemid 38292047)
19. Michaud A.P., Bauman N.M., and Burke D.K. Spastic diplegia and other motor disturbances in infants receiving interferon-alpha Laryngoscope 114 2004 1231 1236 (Pubitemid 38954577)