Interferon-α for alarming hemangiomas in infants: Experience of a single institution

Pediatrics International

Volumn 51, Issue 4, 2009, Pages 469-473

  Chao, Yu Hua ^a,b   Liang, Der Cherng ^a   Chen, Shu Huey ^a   Wang, Lin Yen ^a   Yeh, Ting Chi ^a   Liu, Hsi Che ^a,c  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

Author keywords

Hemangioendothelioma; Hemangioma; Infant; Interferon ; Kasabach Merritt syndrome

Indexed keywords

RECOMBINANT ALPHA2B INTERFERON;

ANOREXIA; ARTICLE; CHILDHOOD CANCER; CHILL; CLINICAL ARTICLE; CLINICAL EVALUATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; DRUG USE; DRUG WITHDRAWAL; FATIGUE; FEMALE; FEVER; FLU LIKE SYNDROME; HEMANGIOMA; HOSPITAL; HUMAN; INFANCY; INFANT; INFECTION; INVOLUTION; MALE; MEDICAL RECORD; MOTOR DYSFUNCTION; NEUROLOGICAL COMPLICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; SINGLE DRUG DOSE; SPASTIC DIPLEGIA; TAIWAN; THERAPY EFFECT; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR VOLUME; WEIGHT GAIN;

ANGIOGENESIS INHIBITORS; FACIAL NEOPLASMS; FEMALE; HEMANGIOMA; HUMANS; INFANT; INTERFERON ALFA-2B; LIVER NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 68349141130     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2008.02770.x     Document Type: Article

References (35)

1. Weber TR, Connors RH, Tracy TF, Bailey PV. Complex hemangiomas of infants and children: Individualized management in 22 cases. Arch. Surg. 1990 125 : 1017 21.
2. Silverman RA. Hemangiomas and vascular malformations. Pediatr. Clin. North Am. 1991 38 : 811 34.
3. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N. Engl. J. Med. 1999 341 : 173 81.
4. McLaughlin MR, O'Connor NR, Ham P. Newborn skin: Part II. Birthmarks. Am. Fam. Physician 2008 77 : 56 60.
5. Sundine MJ, Wirth GA. Hemangiomas: An overview. Clin. Pediatr. 2007 46 : 206 21.
6. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N. Engl. J. Med. 1992 326 : 1456 63.
7. Haggstrom AN, Drolet BA, Baselga E et al. Prospective study of infantile hemangiomas: Clinical characteristics predicting complications and treatment. Pediatrics 2006 118 : 882 7.
8. Higuera S, Gordley K, Metry DW, Stal S. Management of hemangiomas and pediatric vascular malformations. J. Craniofac. Surg. 2006 17 : 783 9.
9. Enjolras O, Riche MC, Merland JJ, Escande JP. Management of alarming hemangiomas in infancy: A review of 25 cases. Pediatrics 1990 85 : 491 8.
10. Shin HY, Ryu KH, Ahn HS. Stepwise multimodal approach in the treatment of Kasabach-Merritt syndrome. Pediatr. Int. 2000 42 : 620 24.
11. Taki M, Ohi C, Yamashita A et al. Successful treatment with vincristine of an infant with intractable Kasabach-Merritt syndrome. Pediatr. Int. 2006 48 : 82 4.
12. Atherton DJ. Infantile haemangiomas. Early Hum. Dev. 2006 82 : 789 95.
13. Boon LM, Burrows PE, Paltiel HJ et al. Hepatic vascular anomalies in infancy: A twenty-seven-year experience. J. Pediatr. 1996 129 : 346 54.
14. Argenta LC, David LR, Sanger C, Park C. Advances in hemangioma evaluation and treatment. J. Craniofac. Surg. 2006 17 : 748 55.
15. Stier MF, Glick SA, Hirsch RJ. Laser treatment of pediatric vascular lesions: Port wine stains and hemangiomas. J. Am. Acad. Dermatol. 2008 58 : 261 85.
16. Phung TL, Hochman M, Mihm MC. Current knowledge of the pathogenesis of infantile hemangiomas. Arch. Facial Plast. Surg. 2005 7 : 319 21.
17. Greinwald JH, Burke DK, Bonthius DJ, Bauman NM, Smith RJH. An update on the treatment of hemangiomas in children with interferon alfa-2a. Arch. Otolaryngol. Head Neck Surg. 1999 125 : 21 7.
18. Battegay EJ. Angiogenesis: Mechanistic insights, neovascular diseases, and therapeutic prospects. J. Mol. Med. 1995 73 : 333 46.
19. Sgonc R, Fuerhapter C, Boeck G, Swerlick RA, Fritsch P, Sepp N. Induction of apoptosis in human dermal microvascular endothelial cells and infantile hemangiomas by interferon-alpha. Int. Arch. Allergy Immunol. 1998 117 : 209 14.
20. Folkman J, Ingber D. Inhibition of angiogenesis. Semin. Cancer Biol. 1992 3 : 89 96.
21. White CW, Sondheimer HM, Crouch EC et al. Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a. N. Engl. J. Med. 1989 320 : 1197 200.
22. Frevel T, Rabe H, Uckert F, Harms E. Giant cavernous haemangioma with Kasabach-Merritt syndrome: A case report and review. Eur. J. Pediatr. 2002 161 : 243 6.
23. Pransky SM, Canto C. Management of subglottic hemangioma. Curr. Opin. Otolaryngol. Head Neck Surg. 2004 12 : 509 12.
24. Rogers M. Treatment of 'angiomas': A modern commentary. Australas. J. Dermatol. 2000 41 (Suppl S89 91.
25. Deb G, Donfrancesco A, Sio LD, Standoli L. Treatment of hemangiomas of infants and babies with interferon alfa-2a: Preliminary results. Int. J. Pediatr. Hematol. Oncol. 1996 3 : 109 13.
26. Chang E, Boyd A, Nelson CC et al. Successful treatment of infantile hemangiomas with interferon-alpha-2b. J. Pediatr. Hematol. Oncol. 1997 19 : 237 44.
27. Worle H, Maass E, Kohler B, Treuner J. Interferon alpha-2a therapy in haemangiomas of infancy: Spastic diplegia as a severe complication. Eur. J. Pediatr. 1999 158 : 344.
28. Dubois J, Hershon L, Carmant L et al. Toxicity profile of interferon alfa-2b in children: A prospective evaluation. J. Pediatr. 1999 135 : 782 5.
29. Barlow CF, Priebe CJ, Mulliken JB et al. Spastic diplegia as a complication of interferon alfa-2a treatment of hemangiomas of infancy. J. Pediatr. 1998 132 : 527 30.
30. Michaud AP, Bauman NM, Burke DK et al. Spastic diplegia and other motor disturbances in infants receiving interferon-alpha. Laryngoscope 2004 114 : 1231 6.
31. Benedetto AV. News in treatment of angiomas. J. Eur. Acad. Dermatol. Venereol. 2004 18 : 122 3.
32. Selby DM, Stocker JT, Waclawiw MA et al. Infantile hemangioendothelioma of the liver. Hepatology 1994 20 : 39 45.
33. Weinberg AG, Finegold MJ. Primary hepatic tumors of childhood. Hum. Pathol. 1983 14 : 512 37.
34. Chen CC, Kong MS, Yang CP, Hung IJ. Hepatic hemangioendothelioma in children: Analysis of thirteen cases. Acta Paediatr. Taiwan 2003 44 : 8 13.
35. Sari N, Yalcin B, Akyuz C et al. Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein. Pediatr. Hematol. Oncol. 2006 23 : 639 47.