Small cell lung cancer in an elderly patient: Efficacy of somatostatin analog treatment, a case report

Onkologie

Volumn 34, Issue 3, 2011, Pages 117-120

  Bearz, Alessandra ^a   Lleshi, Arben ^a   Perin, Tiziana ^b   Fratino, Lucia ^a   Venturini, Silvia ^c   Giacalone, Annalisa ^a   Sartor, Ivana ^a   Berretta, Massimiliano ^a   Sulfaro, Sandro ^d   Tirelli, Umberto ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b Pathology Department   (Italy)

^c Radiology   (Italy)

^d General Hospital of Pordenone   (Italy)

Author keywords

Elderly patients; Lung cancer; Small cell lung cancer (SCLC); Therapy

Indexed keywords

CD56 ANTIGEN; CHROMOGRANIN A; CREATININE; CYTOKERATIN AE1; CYTOKERATIN AE3; GLUCOSE; HEMOGLOBIN BETA CHAIN; LACTATE DEHYDROGENASE; OCTREOTIDE; PENTETREOTIDE; PENTETREOTIDE IN 111; SOMATOSTATIN RECEPTOR; SYNAPTOPHYSIN; THYROID TRANSCRIPTION FACTOR 1;

AGED; ANEMIA; ARTICLE; ATELECTASIS; BONE METASTASIS; BRONCHUS BIOPSY; CANCER FATIGUE; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER SCINTISCANNING; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; CREATININE BLOOD LEVEL; DRUG EFFICACY; DYSPNEA; FORCED EXPIRATORY VOLUME; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABORATORY TEST; LUNG FUNCTION TEST; LUNG SCINTISCANNING; LUNG SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; PROTEIN EXPRESSION; THORAX RADIOGRAPHY;

AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; HUMANS; LUNG NEOPLASMS; MALE; OCTREOTIDE; SMALL CELL LUNG CARCINOMA; SOMATOSTATIN; TREATMENT OUTCOME;

EID: 79952264948     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000324669     Document Type: Article

References (31)

1. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC: Tumours of the Lung, Pleura, Thymus and Heart. Lyon, IARC Press, 2004.
2. Righi L, Volante M, Rapa I, Scagliotti GV, Papotti M: Neuroendocrine tumours of the lung. A review of relevant pathological and molecular data. Virchows Arch 2007;451:S51-S59. (Pubitemid 47283377)
3. Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM: Bronchopulmonary neuroendocrine tumours. Cancer 2008;113:5-21.
4. Viberti L, Bongiovanni M, Croce S, Bussolati G: 34bE12 cytokeratin immunodetection in the differential diagnosis of small cell tumors of lung. Int J Surg Pathol 2000;8:317-322. (Pubitemid 32120693)
5. Kaltsas GA, Besser GM, Grossman AB: The diagnosis and medical management of advanced neuroendocrine tumors. Endocr Rev 2004;25:458- 511. (Pubitemid 38780668)
6. Reubi JC: Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev 2003;24:389-427. (Pubitemid 37056239)
7. Papotti M, Croce S, Bello M, Bongiovanni M, Allia E, Schindler M, Bussolati G: Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preoperative octreotide scintigraphy. Virchows Arch 2001;439:787-797. (Pubitemid 33141324)
8. Ameri P, Gatto F, Arvigo M, et al.: Somatostatin receptor scintigraphy in thoracic diseases. J Endocrinol Invest 2007;30:889-902.
9. Herlin G, Kolbeck KG, Menzel PL, Svensson L, Aspelin P, Capitanio A, Axelsson R: Quantitative assessment of 99mTc-depreotide uptake in patients with non-small-cell lung cancer: immunohistochemical correlations. Acta Radiol 2009;50:902- 908.
10. de Herder WW, Lamberts SW: Somatostatin and somatostatin analogues: diagnostic and therapeutics uses. Curr Opin Oncol 2002;14:53-57. (Pubitemid 34072964)
11. Modlin IM, Latich I, Kidd M, Zikusoka M, Eick G: Therapeutic options for gastrointestinal carcinoids. Clin Gastroenterol Hepatol 2006;4:526-547.
12. Kidd M, Drozdov I, Joseph R, Pfragner R, Culler M, Modlin I: Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer 2008;113:690-700.
13. De Dosso S, Bajetta E, Procopio G, et al.: Pulmonary carcinoid tumours: indolent but not benign. Oncology 2007;73:162-168. (Pubitemid 351630045)
14. Kosmidis PA: Treatment of carcinoid of the lung. Curr Opin Oncol 2004;16:146-149. (Pubitemid 38402528)
15. Krenning EP, Kwekkeboom DJ, Bakker WH, et al.: Somatostatin receptor scintigraphy with [111Ind-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 100 patients. Eur J Nucl Med 1993;20:716-731. (Pubitemid 23284773)
16. Monfardini S, Ferrucci L, Fratino L, del Lungo I, Serraino D, Zagonel V: Validation of a multidimensional evaluation scale for use in elderly cancer patients. Cancer 1996;77:395-401. (Pubitemid 26023359)
17. Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, et al.: Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 1999;340:265- 271. (Pubitemid 29063268)
18. Righi L, Volante M, Tavaglione V, et al.: Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 "clinically aggressive" cases. Ann Oncol 2010;21:548-555.
19. Reubi JC, Waser B, Sheppard M, Macaulay V: Somatostatin receptors are present in small cell but not in non-small cell primary lung carcinomas: relationship to EGFR receptors. Int J Cancer 1990;45:269-274. (Pubitemid 20061380)
20. Sagman U, Mullen JB, Kovacs K, Ginsberg R, Reubi JC: Identification of somatostatin receptors in human small cell lung carcinoma. Cancer 1990; 66:2129-2133.
21. Berenger N, Moretti JL, Boaziz C, Vigneron N, Morere JF, Breau JL: Somatostatin receptor imaging in small cell lung cancer. Eur J Cancer 1996;32:1429-1431. (Pubitemid 26246721)
22. Bohuslavizki KH, Brenner W, Gunther M, et al.: Somatostatin receptor scintigraphy in the staging of small cell lung cancer. Nucl Med Commun 1996;17:191-196. (Pubitemid 26101304)
23. Hochstenbag MM, Heidendal GA, Wouters EF, ten Velde GP: 111In octreotide imaging in staging small cell lung cancer. Clin Nucl Med 1997;22:811- 816. (Pubitemid 28069073)
24. Reisinger I, Bohuslavitzki KH, Brenner W, Braune S, Dittrich I, Geide A: Somatostatin receptor scintigraphy in small cell lung cancer: results of a multicentric study. J Nucl Med 1998;39:224-227. (Pubitemid 28114504)
25. O'Byrne KJ, Carney DN: Somatostatin and the lung. Lung Cancer 1993;10:151-172. (Pubitemid 24033202)
26. Fujita T, Yamaji Y, Sato M, Murao K, Takahara J: Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. Life Sci 1994;55:1797-1806.
27. Macaulay VM, Smith IE, Everard MJ, Teale JD, Reubi JC, Millar JL: Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer. Br J Cancer 1991;64:451- 456.
28. Marschke RF Jr, Grill JP, Sloan JA, Wender DB, Levitt R, Mailiard JA: Phase II study of high-dose somatostatin analogue patients either treated or untreated who have extensive small cell lung cancer. Am J Clin Oncol 1999;22:15-17. (Pubitemid 30261582)
29. Pless M, Waldherr C, Maecke H, Buitrago C, Herrmann R, Mueller-Bran J: Targeted radiotherapy for small cell lung cancer using 90Yttrium- DOTATOC, an yttrium-labelled somatostatin analogue: a pilot trial. Lung Cancer 2004;45:365-371.
30. Petersenn S: Efficacy and limits of somatostatin analogs. J Endocrinol Invest 2005;28:53-57.
31. Fueger BJ, Hamilton G, Raderer M, Pangerl T, Traub T, Angelberger P, Baumgartner G, Dudczak R, Virgolini I: Effects of chemotherapeutic agents on expression of somatostatin receptors in pancreatic tumor cells. J Nucl Med 2001;42:1856-1862. (Pubitemid 34016357)