메뉴 건너뛰기




Volumn 2, Issue 3, 2010, Pages 1492-1512

The kinase Mirk/dyrk1B: A possible therapeutic target in pancreatic cancer

Author keywords

Dyrk; K ras; Mirk; Reactive oxygen species (ROS)

Indexed keywords

K RAS PROTEIN; PROTEIN MIRK; PROTEIN SERINE THREONINE KINASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 79952264076     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers2031492     Document Type: Review
Times cited : (18)

References (36)
  • 1
    • 0242329867 scopus 로고    scopus 로고
    • Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas
    • Stanton, K.J.; Sidner, R.A.; Miller, G.A.; Cummings, O.W.; Schmidt, C.M.; Howard, T.J.; Wiebke, E.A. Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas. Am. J. Surg. 2003, 186, 486-492.
    • (2003) Am. J. Surg. , vol.186 , pp. 486-492
    • Stanton, K.J.1    Sidner, R.A.2    Miller, G.A.3    Cummings, O.W.4    Schmidt, C.M.5    Howard, T.J.6    Wiebke, E.A.7
  • 3
    • 0030022273 scopus 로고    scopus 로고
    • A dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII
    • Kentrup, H.; Becker, W.; Heukelbach, J.; Wilmes, A.; Schurman, A.; Huppertz, C.; Kainulainen, H.; Joost, H.-G. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. J. Biol. Chem. 1996, 271, 3488-3495.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3488-3495
    • Kentrup, H.1    Becker, W.2    Heukelbach, J.3    Wilmes, A.4    Schurman, A.5    Huppertz, C.6    Kainulainen, H.7    Joost, H.-G.D.8
  • 4
    • 0032475973 scopus 로고    scopus 로고
    • Sequence characteristics, subcellular localization and substrate specificity of dyrk-related kinases, a novel family of dual specificity protein kinases
    • Becker, W.; Weber, Y.; Wetzel, K.; Eirmbter, K.; Tejedor, F.; Joost, H.G. Sequence characteristics, subcellular localization and substrate specificity of dyrk-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 1998, 273, 25893-25902.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25893-25902
    • Becker, W.1    Weber, Y.2    Wetzel, K.3    Eirmbter, K.4    Tejedor, F.5    Joost, H.G.6
  • 5
    • 21844468764 scopus 로고    scopus 로고
    • Mirk/Dyrk1B Mediates Survival during the Differentiation of C2C12 Myoblasts
    • Mercer, S.E.; Ewton, D.Z.; Deng, X.; Lim, S.; Mazur, T.R.; Friedman, E. Mirk/Dyrk1B Mediates Survival during the Differentiation of C2C12 Myoblasts. J. Biol. Chem. 2005, 280, 25788-25801.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25788-25801
    • Mercer, S.E.1    Ewton, D.Z.2    Deng, X.3    Lim, S.4    Mazur, T.R.5    Friedman, E.6
  • 8
    • 0037033107 scopus 로고    scopus 로고
    • DYRK3 Activation, Engagement of Protein Kinase A/cAMP Response Element-binding Protein, and Modulation of Progenitor Cell Survival
    • Li, K.; Zhao, S.; Karur, V.; Wojchowski, D.M. DYRK3 Activation, Engagement of Protein Kinase A/cAMP Response Element-binding Protein, and Modulation of Progenitor Cell Survival. J. Biol. Chem. 2002, 277, 47052-47060.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47052-47060
    • Li, K.1    Zhao, S.2    Karur, V.3    Wojchowski, D.M.4
  • 9
    • 33847278486 scopus 로고    scopus 로고
    • The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice
    • Sacher, F.; Moller, C.; Bone, W.; Gottwald, U.; Fritsch, M. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. Mol. Cell. Endocrinol. 2007, 267, 80-88.
    • (2007) Mol. Cell. Endocrinol. , vol.267 , pp. 80-88
    • Sacher, F.1    Moller, C.2    Bone, W.3    Gottwald, U.4    Fritsch, M.5
  • 10
    • 0037591588 scopus 로고    scopus 로고
    • Alternative splicing variants of the protein kinase DYRK1B exhibit distinct patterns of expression and functional properties
    • Leder, S.; Czajkowska, H.; Maenz, B.; de Graaf, K.; Barthel, A.; Joost, H.G.; Becker, W. Alternative splicing variants of the protein kinase DYRK1B exhibit distinct patterns of expression and functional properties. Biochem. J. 2003, 372, 881-888.
    • (2003) Biochem. J. , vol.372 , pp. 881-888
    • Leder, S.1    Czajkowska, H.2    Maenz, B.3    de Graaf, K.4    Barthel, A.5    Joost, H.G.6    Becker, W.7
  • 11
    • 34547630697 scopus 로고    scopus 로고
    • The survival kinase Mirk/dyrk1B is a downstream effector of oncogenic K-ras
    • Jin, K.; Park, S.J.; Ewton, D.; Friedman, E. The survival kinase Mirk/dyrk1B is a downstream effector of oncogenic K-ras. Cancer Res. 2007, 67, 7247-7255.
    • (2007) Cancer Res. , vol.67 , pp. 7247-7255
    • Jin, K.1    Park, S.J.2    Ewton, D.3    Friedman, E.4
  • 12
    • 33646247855 scopus 로고    scopus 로고
    • The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma
    • Deng, X.; Ewton, D.Z.; Li, S.; Naqvi, A.; Mercer, S.E.; Landas, S.; Friedman, E. The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2006, 66, 4149-4158.
    • (2006) Cancer Res. , vol.66 , pp. 4149-4158
    • Deng, X.1    Ewton, D.Z.2    Li, S.3    Naqvi, A.4    Mercer, S.E.5    Landas, S.6    Friedman, E.7
  • 13
    • 0034235542 scopus 로고    scopus 로고
    • Mirk Protein Kinase Is a Mitogen-activated Protein Kinase Substrate That Mediates Survival of Colon Cancer Cells
    • Lee, K.; Deng, X.; Friedman, E. Mirk Protein Kinase Is a Mitogen-activated Protein Kinase Substrate That Mediates Survival of Colon Cancer Cells. Cancer Res 2000, 60, 3631-3637.
    • (2000) Cancer Res. , vol.60 , pp. 3631-3637
    • Lee, K.1    Deng, X.2    Friedman, E.3
  • 14
    • 33745700257 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma- genetic portrait from chromosomes to microarrays
    • Karhu, R.; Mahlamaki, E.; Kallioniemi, A. Pancreatic adenocarcinoma- genetic portrait from chromosomes to microarrays. Genes Chromosomes Cancer 2006, 45, 721-730.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 721-730
    • Karhu, R.1    Mahlamaki, E.2    Kallioniemi, A.3
  • 19
    • 0037067736 scopus 로고    scopus 로고
    • Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha
    • Lim, S.; Jin, K.; Friedman, E. Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha. J. Biol. Chem. 2002, 277, 25040-25046.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25040-25046
    • Lim, S.1    Jin, K.2    Friedman, E.3
  • 20
    • 0037147222 scopus 로고    scopus 로고
    • The Transcriptional Activator Mirk/Dyrk1B Is Sequestered by p38alpha /beta MAP Kinase
    • Lim, S.; Zou, Y.; Friedman, E. The Transcriptional Activator Mirk/Dyrk1B Is Sequestered by p38alpha /beta MAP Kinase. J. Biol. Chem. 2002, 277, 49438-49445.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49438-49445
    • Lim, S.1    Zou, Y.2    Friedman, E.3
  • 21
    • 29644442895 scopus 로고    scopus 로고
    • The Survival Kinase Mirk/dyrk1B Is Activated through Rac1-MKK3 Signaling
    • Jin, K.; Lim, S.; Mercer, S.E.; Friedman, E. The Survival Kinase Mirk/dyrk1B Is Activated through Rac1-MKK3 Signaling. J. Biol. Chem. 2005, 280, 42097-42105.
    • (2005) J. Biol. Chem. , vol.280 , pp. 42097-42105
    • Jin, K.1    Lim, S.2    Mercer, S.E.3    Friedman, E.4
  • 22
    • 14244258401 scopus 로고    scopus 로고
    • Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation
    • Deng, X.; Ewton, D.Z.; Mercer, S.E.; Friedman, E. Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation. J. Biol. Chem. 2005, 280, 4894-4905.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4894-4905
    • Deng, X.1    Ewton, D.Z.2    Mercer, S.E.3    Friedman, E.4
  • 23
    • 0142071703 scopus 로고    scopus 로고
    • Mirk/dyrk1B Is a Rhoinduced Kinase Active in Skeletal Muscle Differentiation
    • Deng, X.; Ewton, D.Z.; Pawlikowski, B.; Maimone, M.; Friedman, E. Mirk/dyrk1B Is a Rhoinduced Kinase Active in Skeletal Muscle Differentiation. J. Biol. Chem. 2003, 278, 41347-41354.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41347-41354
    • Deng, X.1    Ewton, D.Z.2    Pawlikowski, B.3    Maimone, M.4    Friedman, E.5
  • 24
    • 2542489078 scopus 로고    scopus 로고
    • The Cyclin-dependent Kinase Inhibitor p27Kip1 Is Stabilized in G0 by Mirk/dyrk1B Kinase
    • Deng, X.; Mercer, S.E.; Shah, S.; Ewton, D.Z.; Friedman, E. The Cyclin-dependent Kinase Inhibitor p27Kip1 Is Stabilized in G0 by Mirk/dyrk1B Kinase. J. Biol. Chem. 2004, 279, 22498-22504.
    • (2004) J. Biol. Chem , vol.279 , pp. 22498-22504
    • Deng, X.1    Mercer, S.E.2    Shah, S.3    Ewton, D.Z.4    Friedman, E.5
  • 26
    • 33744516825 scopus 로고    scopus 로고
    • Use of Retrovirus Expression of Interfering RNA to Determine the Contribution of Activated K-Ras and Ras Effector Expression to Human Tumor Cell Growth
    • Baines, A.T.; Lim, K.; Shields, J.M.; Lambert, J.M.; Counter, C.M.; Der, C.J.; Cox, A.D.; Balch, W.; Der, C.; Hall, A. Use of Retrovirus Expression of Interfering RNA to Determine the Contribution of Activated K-Ras and Ras Effector Expression to Human Tumor Cell Growth. Methods Enzymol. 2006, 407, 556-574.
    • (2006) Methods Enzymol. , vol.407 , pp. 556-574
    • Baines, A.T.1    Lim, K.2    Shields, J.M.3    Lambert, J.M.4    Counter, C.M.5    Der, C.J.6    Cox, A.D.7    Balch, W.8    Der, C.9    Hall, A.10
  • 27
    • 65949118505 scopus 로고    scopus 로고
    • Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by decreasing ROS levels
    • Deng, X.; Ewton, D.Z.; Friedman, E. Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by decreasing ROS levels. Cancer Res. 2009, 69, 3317-3324.
    • (2009) Cancer Res. , vol.69 , pp. 3317-3324
    • Deng, X.1    Ewton, D.Z.2    Friedman, E.3
  • 28
    • 0037211485 scopus 로고    scopus 로고
    • Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants
    • Ewton, D.; Lee, K.; Deng, X.; Lim, S.; Friedman, E. Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. Int. J. Cancer 2003, 103, 21-28.
    • (2003) Int. J. Cancer , vol.103 , pp. 21-28
    • Ewton, D.1    Lee, K.2    Deng, X.3    Lim, S.4    Friedman, E.5
  • 30
    • 0037192473 scopus 로고    scopus 로고
    • Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway
    • Nemoto, S.; Finkel, T. Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway. Science 2002, 295, 2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 31
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano, H.; Carney, D.; Huang, P. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updat. 2004, 7, 97-110.
    • (2004) Drug Resist. Updat. , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 33
    • 0034633645 scopus 로고    scopus 로고
    • From the Cover: Proliferation is necessary for both repair and mutation in transgenic mouse cells
    • Bielas, J.H.; Heddle, J.A. From the Cover: Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proc. Natl. Acad. Sci. USA 2000, 97, 11391-11396.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11391-11396
    • Bielas, J.H.1    Heddle, J.A.2
  • 34
    • 2642516979 scopus 로고    scopus 로고
    • Quiescent murine cell lack global genomic repair but are proficient in transcription-coupled repair
    • Bielas, J.H.; Heddle, J.A. Quiescent murine cell lack global genomic repair but are proficient in transcription-coupled repair. DNA Repair 2004, 3, 711-717.
    • (2004) DNA Repair. , vol.3 , pp. 711-717
    • Bielas, J.H.1    Heddle, J.A.2
  • 35
    • 55349137357 scopus 로고    scopus 로고
    • C-Cbl Interacts with CD38 and Promotes Retinoic Acid-Induced Differentiation and G0 Arrest of Human Myeloblastic Leukemia Cells
    • Shen, M.; Yen, A. c-Cbl Interacts with CD38 and Promotes Retinoic Acid-Induced Differentiation and G0 Arrest of Human Myeloblastic Leukemia Cells. Cancer Res. 2008, 68, 8761-8769.
    • (2008) Cancer Res. , vol.68 , pp. 8761-8769
    • Shen, M.1    Yen, A.2
  • 36
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen, C.; Liu, Y.; Liu, R.; Ikenoue, T.; Guan, K.L.; Liu, Y.; Zheng, P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008, 205, 2397-2408.
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.