What is nonacid reflux disease?

Canadian Journal of Gastroenterology

Volumn 25, Issue 1, 2011, Pages 35-38

  Storr, Martin A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Arbaclofen ADX 10059; GERD; Lesogaberan; Proton pump inhibitor; Reflux

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ADX 10059; ALCOHOL; ARBACLOFEN PLACARBIL; AZD 9343; BACLOFEN; LESOGABERAN; METABOTROPIC GLUTAMATE RECEPTOR 5 ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; NICOTINE; PLACEBO; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; DRUG DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PROPYLAMINE;

ADD ON THERAPY; ALCOHOL ABSTINENCE; ANTIREFLUX OPERATION; DIGESTIVE SYSTEM EXAMINATION; ESOPHAGEAL PH MONITORING; ESOPHAGUS MANOMETRY; GASTROESOPHAGEAL REFLUX; HUMAN; LIFESTYLE MODIFICATION; MULTICHANNEL INTRALUMINAL IMPEDANCE; NONACID REFLUX DISEASE; NOTE; PRIORITY JOURNAL; SINGLE DRUG DOSE; SMOKING CESSATION; UNSPECIFIED SIDE EFFECT; WEIGHT REDUCTION; ARTICLE; DRUG EFFECT; LOWER ESOPHAGUS SPHINCTER; PATHOPHYSIOLOGY;

BACLOFEN; ESOPHAGEAL SPHINCTER, LOWER; GASTROESOPHAGEAL REFLUX; HUMANS; PHOSPHINIC ACIDS; PROPYLAMINES; PROTON PUMP INHIBITORS; RECEPTORS, GABA-A;

EID: 79952263141     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: 10.1155/2011/626752     Document Type: Note

References (17)

1. Storr M, Meining A, Allescher HD. Pharmacoeconomic issues of the therapy of gastroesophageal reflux disease. Exp Opin Pharmacother 2001;2:1099-108. (Pubitemid 32633712)
2. Armstrong D, Pare P, Pericak D, Pyzyk M. Symptom relief in gastroesophageal reflux disease: A randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease. Am J Gastroenterol 2001;96:2849-57. (Pubitemid 32959523)
3. Meineche-Schmidt V, Juhl HH, Ostergaard JE, Luckow A, Hvenegaard A. Costs and efficacy of three different esomeprazole treatment strategies for long-term management of gastro-oesophageal reflux symptoms in primary care. Aliment Pharmacol Ther 2004;19:907-15. (Pubitemid 38534820)
4. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: A multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006;55:1398-402. (Pubitemid 44476780)
5. Sifrim D, Dupont L, Blondeau K, Zhang X, Tack J, Janssens J. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 2005;54:449-54. (Pubitemid 40395491)
6. Tutuian R, Mainie I, Agrawal A, Adams D, Castell DO. Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest 2006;130:386-91. (Pubitemid 44267004)
7. Nguyen HN, Silny J, Matern S. Multiple intraluminal electrical impedancometry for recording of upper gastrointestinal motility: Current results and further implications. Am J Gastroenterol 1999;94:306-17. (Pubitemid 29084645)
8. Vela MF, Camacho-Lobato L, Srinivasan R, Tutuian R, Katz PO, Castell DO. Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: Effect of omeprazole. Gastroenterology 2001;120:1599-606. (Pubitemid 32523479)
9. Smout AJ. The measurement of non-acid gastro-oesophageal reflux. Aliment Pharmacol Ther 2007;26(Suppl 2):7-12.
10. Sifrim D, Castell D, Dent J, Kahrilas PJ. Gastro-oesophageal reflux monitoring: Review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004;53:1024-31. (Pubitemid 38824163)
11. Lidums I, Lehmann A, Checklin H, Dent J, Holloway RH. Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects. Gastroenterology 2000;118:7-13. (Pubitemid 30020367)
12. Ciccaglione AF, Marzio L. Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. Gut 2003;52:464-70. (Pubitemid 36367205)
13. Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther 2003;17:243-51. (Pubitemid 36174255)
14. Boeckxstaens GE, Rydholm H, Lei A, Adler J, Ruth M. Effect of lesogaberan, a novel GABA-receptor agonist, on transient lower esophageal sphincter relaxations in male subjects. Aliment Pharmacol Ther 2010;11:1208-17.
15. Beaumont H, Smout A, Aanen M, et al. The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: A phase I study. Aliment Pharmacol Ther 2009;30:937-46.
16. Gerson LB, Huff FJ, Hila A, et al. Arbaclofen Placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease. Am J Gastroenterol 2010;105:1266-75.
17. Mainie I, Tutuian R, Agrawal A, Adams D, Castell DO. Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 2006;93:1483-7. (Pubitemid 44893649)