Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1244-1255

  Nakagawa Goto, Kyoko ^a   Wu, Pei Chi ^a   Lai, Chin Yu ^a   Hamel, Ernest ^b   Zhu, Hao ^c   Zhang, Liying ^c   Kozaka, Takashi ^a   Ohkoshi, Emika ^a   Goto, Masuo ^d   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a,e  

^a University of North Carolina at Chapel Hill   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1' METHYL 1H INDOL 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (1',2' DIHYDROACENAPHTHYLEN 5' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (2' METHYLBENZO[B]THIOPHEN 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (2' METHYLNAPHTHALEN 1' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (2',3' DIHYDROBENZO[D][1',4']DIOXIN 6' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (2',3' DIMETHOXYNAPHTHALEN 1' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (3' METHYLBENZO[B]THIOPHEN 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (4' METHOXYNAPHTHALEN 1' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (4' METHYLNAPHTHALEN 1' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (4',7' DIMETHOXYNAPHTHALEN 1' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (5' BROMOBENZO[B]THIOPHEN 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (5' HYDROXYBENZO[B]THIOPHEN 4' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (5' METHOXYBENZO[B]THIOPHEN 4' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (5' METHYLBENZO[B]THIOPHEN 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (6' METHOXYNAPHTHALEN 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (9' ETHYL 9'H CARBAZOL 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZO[B]THIOPHEN 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZO[B]THIOPHEN 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZO[B]THIOPHEN 7' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZO[D][1',3']DIOXOL 5' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZOFURAN 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (BENZOFURAN 3' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 2 (NAPHTHALEN 1' YL) 6,8,8 TRIPROPYLDESMOSDUMOTIN B; 2 (NAPHTHALEN 2' YL) 6,8,8 TRIETHYLDESMOSDUMOTIN B; 6,8,8 TRIETHYL 2 (QUINOLIN 3' YL)DESMOSDUMOTIN B; ANTINEOPLASTIC AGENT; DESMOSDUMOTIN B DERIVATIVE; GLYCOPROTEIN P; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MULTIDRUG RESISTANCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMONES; COLCHICINE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAPHTHALENES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TUBULIN; TUBULIN MODULATORS;

EID: 79952258907     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1011947     Document Type: Article

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