Cells from a vanished twin as a source of microchimerism 40 years later

Chimerism

Volumn 1, Issue 2, 2010, Pages

  de Bellefon, Laurent Meric ^a   Heiman, Pierre ^b   Kanaan, Sami B ^c   Azzouz, Doua F ^c   Rak, Justyna M ^c   Martin, Marielle ^c   Roudier, Jean ^c,d   Roufosse, Florence ^a,e   Lambert, Nathalie C ^c  

^a Institute for Medical Immunology

^b Laboratory of Cytogenetics

^c INSERM   (France)

^d HÔPITAL DE LA CONCEPTION   (France)

^e ERASME HOSPITAL   (Belgium)

Author keywords

Chimerism; Gender; HLA specific PCR; Scleroderma; Twin

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID DERIVATIVE; DNA; HLA A ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

ADULT; ARTICLE; BELGIUM; CASE REPORT; CHROMOSOME ANALYSIS; DNA EXTRACTION; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE AMPLIFICATION; GRAFT VERSUS HOST REACTION; HAPLOTYPE; HISTOCOMPATIBILITY COMPLEX; HUMAN; MALE; MICROCHIMERISM; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; SCLERODERMA; TWINS; X CHROMOSOME; Y CHROMOSOME;

EID: 79952254201     PISSN: 19381956     EISSN: 19381964     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Morrow J, Nelson JL, Watts R, Isenberg D. Scleroderma. In: Maddison P, Isenberg D, Glass D, Woo P, Eds. Autoimmune Rheumatic Disease. Oxford University Press 1999; 194-215.
2. Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, et al. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 1998; 351:559-62.
3. Artlett CM, Smith JB, Jimenez SA: Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis. N Engl J Med 1998; 338:1186-91.
4. Rak JM, Pagni PP, Tiev K, Allanore Y, Farge D, Harle JR, et al. Male microchimerism and HLA compatibility in French women with sclerodema: a different profile in limited and diffuse subset. Rheumatology 2009; 48:363-6.
5. Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, Nelson JL. Microchimerism of maternal origin persists into adult life. J Clin Invest 1999; 104:41-7.
6. Hall JM, Lingenfelter P, Adams SL, Lasser D, Hansen JA, Bean MA. Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 1995; 86:2829-32.
7. Bauer M, Orescovic I, Schoell WM, Bianchi DW, Pertl B. Detection of maternal deoxyribonucleic acid in umbilical cord plasma by using fluorescent polymerase chain reaction amplification of short tandem repeat sequences. Am J Obstet Gynecol 2002; 186:117-20.
8. Pollack MS, Kapoor N, Sorell M, Kim SJ, Christiansen FT, Silver DM, et al. DR-positive maternal engrafted T cells in a severe combined immunodeficiency patient without graft-versus-host disease. Transplantation 1980; 30:331-4.
9. Lambert NC, Erickson TD, Yan Z, Pang JM, Guthrie KA, Furst DE, Nelson JL. Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction-Studies of healthy women and women with scleroderma. Arthritis Rheum 2004; 50:906-14.
10. Robinson HP, Caines JS. Sonar evidence of early pregnancy failure in patients with twin conceptions. Br J Obstet Gynaecol 1977; 84:22-5.
11. LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001; 28:1573-6.
12. Rak JM, Maestroni L, Balandraud N, Guis S, Boudinet H, Guzian MC, et al. Transfer of the shared epitope through microchimerism in women with rheumatoid arthritis. Arthritis Rheum 2009; 60:73-80.
13. Vollmann J, Winau R. Informed consent in human experimentation before the Nuremberg code. Bmj 1996; 313:1445-9.
14. O'Donoghue K, Chan J, de la Fuente J, Kennea N, Sandison A, Anderson JR, et al. Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy. Lancet 2004; 364:179-82.
15. Christner PJ, Artlett CM, Conway RF, Jimenez SA. Increased numbers of microchimeric cells of fetal origin are associated with dermal fibrosis in mice following injection of vinyl chloride. Arthritis Rheum 2000; 43:2598-605.
16. Nelson JL. Microchimerism: incidental byproduct of pregnancy or active participant in human health? Trends Mol Med 2002; 8:109-13.