Human hypertrophic scar-like nude mouse model: Characterization of the molecular and cellular biology of the scar process

Wound Repair and Regeneration

Volumn 19, Issue 2, 2011, Pages 274-285

  Wang, Jianfei ^a   Ding, Jie ^a   Jiao, Haiyan ^a   Honardoust, Dariush ^a   Momtazi, Moein ^a   Shankowsky, Heather A ^a   Tredget, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACK; CONTROLLED STUDY; FULL THICKNESS SKIN GRAFT; HISTOLOGY; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAST CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; SKIN GRAFT; SPLIT THICKNESS SKIN GRAFT;

ANIMALS; CICATRIX, HYPERTROPHIC; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; HSP47 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, ANIMAL; MYOFIBROBLASTS; SKIN; SKIN TRANSPLANTATION; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTATION, HETEROLOGOUS;

EID: 79952253714     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2011.00672.x     Document Type: Article

References (44)

1. Tredget EE, Nedelec B, Scott PG, Ghahary A., Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. Surg Clin North Am 1997; 77: 701-30. (Pubitemid 27256042)
2. Scott PG, Ghahary A, Wang J, Tredget EE., Molecular and cellular basis of hypertrophic scarring. In:, Herndon DN, editor. Total burn care. London: Saunders Elsevier, 2007: 596-608.
3. Tredget EE, Yang L, Delehanty M, Shankowsky H, Scott PG., Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury. J Interferon Cytokine Res 2006; 26: 179-89.
4. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE., Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor. J Interferon Cytokine Res 2008; 28: 423-34. (Pubitemid 351986398)
5. Morris DE, Wu L, Zhao LL, Bolton L, Roth SI, Ladin DA, Mustoe TA., Acute and chronic animal models for excessive dermal scarring: quantitative studies. Plast Reconstr Surg 1997; 100: 674-81. (Pubitemid 27381074)
6. Lee JP, Jalili RB, Tredget EE, Demare JR, Ghahary A., Antifibrogenic effects of liposome-encapsulated IFN-alpha2b cream on skin wounds in a fibrotic rabbit ear model. J Interferon Cytokine Res 2005; 25: 627-31. (Pubitemid 41507818)
7. Kischer CW, Sheridan D, Pindur J., Use of nude (athymic) mice for the study of hypertrophic scars and keloids: vascular continuity between mouse and implants. Anat Rec 1989; 225: 189-96.
8. Kischer CW, Wagner HN Jr., Pindur J, Holubec H, Jones M, Ulreich JB, Scuderi P., Increased fibronectin production by cell lines from hypertrophic scar and keloid. Connect Tissue Res 1989; 23: 279-88.
9. Kischer CW, Pindur J, Shetlar MR, Shetlar CL., Implants of hypertrophic scars and keloids into the nude (athymic) mouse: viability and morphology. J Trauma 1989; 29: 672-7. (Pubitemid 19156503)
10. Shetlar MR, Shetlar CL, Kischer CW, Pindur J., Implants of keloid and hypertrophic scars into the athymic nude mouse: changes in the glycosaminoglycans of the implants. Connect Tissue Res 1991; 26: 23-36.
11. Polo M, Kim YJ, Kucukcelebi A, Hayward PG, Ko F, Robson MC., An in vivo model of human proliferative scar. J Surg Res 1998; 74: 187-95. (Pubitemid 28270369)
12. Silverstein P, Helmkamp GM Jr., Walker HL, McKeel DW Jr., Pruitt BA Jr., Laboratory evaluation of enzymatic burn wound debridement in vitro and in vivo. Surg Forum 1972; 23: 31-3.
13. Zhu KQ, Engrav LH, Gibran NS, Cole JK, Matsumura H, Piepkorn M, Isik FF, Carrougher GJ, Muangman PM, Yunusov MY, Yang TM., The female, red Duroc pig as an animal model of hypertrophic scarring and the potential role of the cones of skin. Burns 2003; 29: 649-64. (Pubitemid 37230079)
14. Yang DY, Li SR, Wu JL, Chen YQ, Li G, Bi S, Dai X., Establishment of a hypertrophic scar model by transplanting full-thickness human skin grafts onto the backs of nude mice. Plast Reconstr Surg 2007; 119: 104-9; discussion 110-101. (Pubitemid 46360252)
15. Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE., Increased severity of bleomycin-induced skin fibrosis in mice with leukocyte-specific protein 1 deficiency. J Invest Dermatol 2008; 128: 2767-76. Epub 2008 Jun 26.
16. Wang J, Jiao H, Stewart TL, Lyons MV, Shankowsky HA, Scott PG, Tredget EE., Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes. J Leukoc Biol 2007; 82: 1554-63. (Pubitemid 350276967)
17. Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE., Improvement in postburn hypertrophic scar after treatment with IFN-alpha2b is associated with decreased fibrocytes. J Interferon Cytokine Res 2007; 27: 921-30. (Pubitemid 350223113)
18. Liu L, Cara DC, Kaur J, Raharjo E, Mullaly SC, Jongstra-Bilen J, Jongstra J, Kubes P., LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. J Exp Med 2005; 201: 409-18. (Pubitemid 40229415)
19. Metcalfe DD., Isolation of tissue mast cells. Curr Protoc Immunol 2001; 25. Chapter 7: Unit 7.25: 7.25. 1-3.
20. Nagata K., Hsp47 a collagen-specific molecular chaperone. Trends Biochem Sci 1996; 21: 22-6.
21. Leask A, Abraham DJ., TGF-beta signaling and the fibrotic response. FASEB J 2004; 18: 816-27.
22. Leask A., Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis. Keio J Med 2004; 53: 74-7. (Pubitemid 38899739)
23. Wang JF, Wu YJ, Medina A, Scott PG, Tredget EE., Role of fibrocytes in pathogenic scar formation in fibrocytes: new insights into tissue repair and systemic fibroses. New York: World Scientific Publishing Co., 2007: 75-105.
24. Tredget EE, Shankowsky HA, Pannu R, Nedelec B, Iwashina T, Ghahary A, Taerum TV, Scott PG., Transforming growth factor-beta in thermally injured patients with hypertrophic scars: effects of interferon alpha-2b. Plast Reconstr Surg 1998; 102: 1317-28; discussion 1329-1330. (Pubitemid 28468668)
25. Quan TE, Cowper SE, Bucala R., The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep 2006; 8: 145-50. (Pubitemid 44623983)
26. Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE., Increased TGF-beta-producing CD4+ T lymphocytes in postburn patients and their potential interaction with dermal fibroblasts in hypertrophic scarring. Wound Repair Regen 2007; 15: 530-9. (Pubitemid 47087646)
27. Aarabi S, Longaker MT, Gurtner GC., Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Med 2007; 4: e234.
28. Reid RR, Roy N, Mogford JE, Zimmerman H, Lee C, Mustoe TA., Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II. J Plast Reconstr Aesthet Surg 2007; 60: 64-72; discussion 73-64. (Pubitemid 44815240)
29. Zhu KQ, Carrougher GJ, Gibran NS, Isik FF, Engrav LH., Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring. Wound Repair Regen 2007; 15 (Suppl. 1): S32-9. (Pubitemid 47301672)
30. Linares HA, Kischer CW, Dobrkovsky M, Larson DL., The histiotypic organization of the hypertrophic scar in humans. J Invest Dermatol 1972; 59: 323-31.
31. Kischer CW., Collagen and dermal patterns in the hypertrophic scar. Anat Rec 1974; 179: 137-45.
32. Kahari VM., Activation of dermal connective tissue in scleroderma. Ann Med 1993; 25: 511-8.
33. Lakos G, Takagawa S, Chen SJ, Ferreira AM, Han G, Masuda K, Wang XJ, DiPietro LA, Varga J., Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004; 165: 203-17. (Pubitemid 38821828)
34. Yang L, Scott PG, Giuffre J, Shankowsky HA, Ghahary A, Tredget EE., Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest 2002; 82: 1183-92.
35. Wang JF, Olson ME, Reno CR, Kulyk W, Wright JB, Hart DA., Molecular and cell biology of skin wound healing in a pig model. Connect Tissue Res 2000; 41: 195-211.
36. Wang JF, Olson ME, Reno CR, Wright JB, Hart DA., The pig as a model for excisional skin wound healing: characterization of the molecular and cellular biology, and bacteriology of the healing process. Comp Med 2001; 51: 341-8.
37. Wang JF, Olson ME, Ball DK, Brigstock DR, Hart DA., Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression. Wound Repair Regen 2003; 11: 220-9. (Pubitemid 36648881)
38. Brigstock DR., The CCN family: a new stimulus package. J Endocrinol 2003; 178: 169-75.
39. Colwell AS, Phan TT, Kong W, Longaker MT, Lorenz PH., Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. Plast Reconstr Surg 2005; 116: 1387-90; discussion 1391-1382. (Pubitemid 41456511)
40. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A., Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994; 1: 71-81.
41. Metz CN., Fibrocytes: a unique cell population implicated in wound healing. Cell Mol Life Sci 2003; 60: 1342-50.
42. Yang L, Scott PG, Dodd C, Medina A, Jiao H, Shankowsky HA, Ghahary A, Tredget EE., Identification of fibrocytes in postburn hypertrophic scar. Wound Repair Regen 2005; 13: 398-404. (Pubitemid 41060421)
43. Wang JF, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE., Fibrocytes from burn patients regulate the activities of fibroblasts. Wound Repair Regen 2007; 15: 113-21. (Pubitemid 46146670)
44. Lupher ML Jr., Gallatin WM., Regulation of fibrosis by the immune system. Adv Immunol 2006; 89: 245-88.