CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53

Oncology Reports

Volumn 25, Issue 4, 2011, Pages 1091-1098

  Zhang, Ya Fei ^a   Li, Xiao Hua ^b   Shi, Yong Quan ^b   Wu, Yu Yun ^a   Li, Ning ^a   He, Qiang ^a   Ji, Qing ^a   Wang, Rong Quan ^a   Yang, Shi Ming ^a   Fang, Dian Chun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bcl xL; CIAPIN1; LoVo Adr; MDR 1; Multidrug resistance; p53

Indexed keywords

DOXORUBICIN; FLUOROURACIL; MITOMYCIN C; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BCL XL; PROTEIN CIAPIN1; PROTEIN P53; UNCLASSIFIED DRUG; VINCRISTINE;

APOPTOSIS; ARTICLE; CARCINOMA CELL; COLON CARCINOMA; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CELL PROLIFERATION; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HUMANS; IMMUNOENZYME TECHNIQUES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOMYCIN; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; VINCRISTINE;

EID: 79952239293     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1148     Document Type: Article

References (30)

1. Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM: Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5: 219-234, 2006. (Pubitemid 43336035)
2. Lage H: An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol Life Sci 65: 3145-3167, 2008.
3. Shibayama H, Takai E, Matsumura I, et al: Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis. J Exp Med 199: 581-592, 2004. (Pubitemid 38233841)
4. Hao Z, Li X, Qiao T, Du R, Hong L and Fan D: CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells. Cancer Biol Ther 5: 261-266, 2006.
5. Li X, Hong L, Zhao Y, et al: A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. Biochem Cell Biol 85: 741-750, 2007. (Pubitemid 351198421)
6. Giovannetti E, Backus HH, Wouters D and Peters GJ: Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. Nucleosides Nucleotides Nucleic Acids 27: 740-745, 2008. (Pubitemid 351948577)
7. Kantharidis P, El-Osta A, de Silva M, et al: Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clin Cancer Res 3: 2025-2032, 1997. (Pubitemid 27505129)
8. Peart MJ, Tainton KM, Ruefli AA, et al: Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res 63: 4460-4471, 2003. (Pubitemid 36951018)
9. Ma Q, Zhang ZS, Zhong SS and Lai ZS: Uptake and distribution of adriamycin in multidrug-resistant LoVo/Adr cells. Di Yi Jun Yi Da Xue Xue Bao 22: 264-266, 2002.
10. Hao Z, Qiao T, Jin X, Li X, Gao J and Fan D: Preparation and characterization of a specific monoclonal antibody against CIAPIN1. Hybridoma (Larchmt) 24: 141-145, 2005. (Pubitemid 40863628)
11. Li X, Pan Y, Fan R, et al: Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo. Carcinogenesis 29: 1587-1593, 2008.
12. Tchénio T, Havard M, Martinez LA and Dautry F: Heat shock-independent induction of multidrug resistance by heat shock factor 1. Mol Cell Biol 26: 580-591, 2006. (Pubitemid 43089770)
13. Zhang Y, Shi Y, Li X, et al: Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp. Cancer Biol Ther 7: 540-546, 2008. (Pubitemid 351847029)
14. Hong L, Piao Y, Han Y, et al: Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2. Mol Cancer Ther 4: 1936-1942, 2005.
15. Baumert C and Hilgeroth A: Recent advances in the development of P-gp inhibitors. Anticancer Agents Med Chem 9: 415-436, 2009.
16. Han Z, Hong L, Han Y, et al: Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res 26: 261-268, 2007. (Pubitemid 47025290)
17. Hao Z, Li X, Qiao T, Du R, Zhang G and Fan D: Subcellular localization of CIAPIN1. J Histochem Cytochem 54: 1437-1444, 2006.
18. Li Y, Yuan H, Yang K, Xu W, Tang W and Li X: The structure and functions of P-glycoprotein. Curr Med Chem 17: 786-800, 2010.
19. Gogvadze V, Orrenius S and Zhivotovsky B: Mitochondria as targets for chemotherapy. Apoptosis 14: 624-640, 2009
20. Cory S and Adams JM: Killing cancer cells by flipping the Bcl-2/Bax switch. Cancer Cell 8: 5-6, 2005. (Pubitemid 40991809)
21. He L, Wang H, Jin H, et al: CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. Cancer Lett 276: 88-94, 2009
22. Yu H and Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 4: 97-105, 2004. (Pubitemid 38198738)
23. Ravi R, Jain AJ, Schulick RD, et al: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. Cancer Res 64: 9105-9114, 2004. (Pubitemid 39665525)
24. Xiong H Zhang ZG, Tian XQ, et al: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 10: 287-297, 2008.
25. Yang, LY and Trujillo JM: Biological characterization of multidrug-resistant human colon carcinoma sublines induced/selected by two methods. Cancer Res 50: 3218-3225, 1990.
26. Jiang XH, Wong BC, Lin MC, et al: Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 20: 8009-8018, 2001. (Pubitemid 34001562)
27. El-Mahdy MA, Zhu Q, Wang QE, Wani G and Wani AA: Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 117: 409-417, 2005. (Pubitemid 41429564)
28. Chen YN, Mickley LA, Schwartz AM, Acton EM, Hwang JL and Fojo AT: Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. J Biol Chem 265: 10073-10080, 1990.
29. Nita ME, Nagawa H, Tominaga O, et al: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. Br J Cancer 78: 986-992, 1998. (Pubitemid 28463972)
30. Sax JK and El-Deiry WS: P53 downstream targets and chemosensitivity. Cell Death Differ 10: 413-417, 2003. (Pubitemid 36626353)