Platelet-rich plasma therapy: A systematic literature review and evidence for clinical use

Physician and Sportsmedicine

Volumn 39, Issue 1, 2011, Pages 42-51

  Redler, Lauren H ^a   Thompson, Scott A ^a   Hsu, Stephanie H ^a   Ahmad, Christopher S ^a   Levine, William N ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Achilles tendon repair; Growth factors; Platelet rich plasma; Rotator cuff repair; Sports medicine; Tendinopathy

Indexed keywords

BOTULINUM TOXIN A; CORTICOSTEROID; CYTOKINE; GROWTH FACTOR;

ACHILLES TENDON RUPTURE; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; CELL PROLIFERATION; CELL REGENERATION; EPICONDYLAR TENDINOSES; HUMAN; LIGAMENT SURGERY; MECHANICAL STIMULATION; MEDIAL COLLATERAL LIGAMENT RECONSTRUCTION; MENISCAL REPAIR; MUSCLE INJURY; MUSCLE STRAIN; NONHUMAN; PATELLAR TENDINOPATHY; RANDOMIZED CONTROLLED TRIAL; REVIEW; ROTATOR CUFF INJURY; SPORT INJURY; SPORTS MEDICINE; SYSTEMATIC REVIEW; SYSTEMATIC REVIEW (TOPIC); TENDINITIS; TENDON INJURY; TENNIS ELBOW; THROMBOCYTE RICH PLASMA; TISSUE REPAIR;

EID: 79952233532     PISSN: 00913847     EISSN: None     Source Type: Journal    
DOI: 10.3810/psm.2011.02.1861     Document Type: Review

References (44)

1. Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA. Platelet-rich plasma: current concepts and application in sports medicine. J Am Acad Orthop Surg. 2009;17(10):602-608.
2. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-646. (Pubitemid 128641964)
3. Sánchez M, Azofra J, Anitua E, et al. Plasma rich in growth factors to treat an articular cartilage avulsion: a case report. Med Sci Sports Exerc. 2003;35(10):1648-1652. (Pubitemid 37221893)
4. Arnoczky SP. Platelet-rich plasma (PRP) to augment connective tissue healing: making sense of it all. J Am Acad Orthop Surg. 2010;18:445-448.
5. de Vos RJ, van Veldhoven PL, Moen MH, Weir A, Tol JL, Maffulli N. Autologous growth factor injections in chronic tendinopathy: a systematic review. Br Med Bull. 2010;95:63-77.
6. Aspenberg P, Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand. 2004;75(1):93-99. (Pubitemid 38264933)
7. Azuma H, Yasuda K, Tohyama H, Sakai T, Majima T, Aoki Y, Minami A. Timing of administration of transforming growth factor-beta and epidermal growth factor influences the effect on material properties of the in situ frozen-thawed anterior cruciate ligament. J Biomech. 2003;36(3): 373-381. (Pubitemid 36197675)
8. Hildebrand KA, Woo SL, Smith DW, et al. The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament. An in vivo study. Am J Sports Med. 1998;26(4):549-554. (Pubitemid 28346042)
9. Sakai T, Yasuda K, Tohyama H, et al. Effects of combined administration of transforming growth factor-beta1 and epidermal growth factor on properties of the in situ frozen anterior cruciate ligament in rabbits. J Orthop Res. 2002;20(6):1345-1351. (Pubitemid 35363996)
10. Woo SL, Smith DW, Hildebrand KA, Zeminski JA, Johnson LA. Engineering the healing of the rabbit medial collateral ligament. Med Biol Eng Comput. 1998;36(3):359-364.
11. Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy. 2010;26(2):269-278.
12. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259-2272.
13. Sánchez M, Anitua E, Orive G, Mujika I, Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009;39(5): 345-354.
14. de Mos M, van der Windt AE, Jahr H, et al. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med. 2008;36(6):1171-1178. (Pubitemid 351713047)
15. Anitua E, Andia I, Sanchez M, et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res. 2005;23(2):281-286. (Pubitemid 40287850)
16. Kajikawa Y, Morihara T, Sakamoto H, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 2008;215(3):837-845. (Pubitemid 351632705)
17. Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Król W, Wielkoszynski T. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br. 2007;89(3):417-420. (Pubitemid 46563928)
18. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br. 2009;91(8):987-996.
19. Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008;1(3-4):165-174.
20. Mishra A, Woodall J Jr, Vieira A. Treatment of tendon and muscle using platelet-rich plasma. Clin Sports Med. 2009;28(1):113-125.
21. Kon E, Filardo G, Delcoghano M, et al. Platelet-rich plasma: new clinical application: a pilot study for treatment of jumpers knee. Injury. 2009;40(6):598-603.
22. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;34(11):1774-1778. (Pubitemid 44735517)
23. Ferretti A, Ippolito E, Mariani P, Puddu G. Jumper's knee. Am J Sports Med. 1983;11:58-62. (Pubitemid 13128290)
24. Edwards SG, Calandruccio JH. Autologous blood injections for refractory lateral epicondylitis. J Hand Surg Am. 2003;28(2):272-278. (Pubitemid 36373325)
25. Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM. Use of autologous platelet-rich plasma to treat muscle strain injuries. Am J Sports Med. 2009;37(6):1135-1142.
26. Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop. 2006;77(5):806-812.
27. Sánchez M, Anitua E, Azofra J, Andia I, Padilla S, Mujika I. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007;35(2):245-251. (Pubitemid 46145405)
28. Schepull T, Kvist J, Norrman H, Trinks M, Berlin G, Aspenberg P. Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study [published online ahead of print November 3,2010]. Am J Sports Med.
29. Ishida K, Kuroda R, Miwa M, et al. The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng. 2007;13(5):1103-1112. (Pubitemid 46870434)
30. Arnoczky SP, Fanelli G, Ho S, Mishra A, Sgaglione N. The role of platelet-rich plasma in connective tissue repair. Orthopaedics Today. 2010; 26:29.
31. Hirahar AM, Yamashiro K, Dunning R. Enhancing SLAP repairs with fibrin-PRP clots. Presented at the 64th Annual Meeting of the Canadian Orthopaedic Association; Whistler, British Columbia, Canada; July 3-6, 2009.
32. Sánchez M, Anitua E, Lopez-Vidriero E, Andia I. The future: optimizing the healing environment in anterior cruciate ligament reconstruction. Sports Med Arthrose. 2010;18(1):48-53.
33. De Long WG Jr, Einhorn TA, Koval K, et al. Bone grafts and bone graft substitutes in orthopaedic trauma surgery. A critical analysis. J Bone Joint Surg Am. 2007;89(3):649-658. (Pubitemid 46365369)
34. Orrego M, Larrain C, Rosales J, et al. Effects of platelet concentrate and a bone plug on the healing of hamstring tendons in a bone tunnel. Arthroscopy. 2008;24(12):1373-1380.
35. Silva A, Sampaio R. Anatomic ACL reconstruction: does the platelet-rich plasma accelerate tendon healing? Knee Surg Sports Traumatol Arthrosc. 2009;17(6):676-682.
36. Maniscalco P, Gambera D, Lunati A, et al. The "Cascade" membrane: a new PRP device for tendon ruptures. Description and case report on rotator cuff tendon. Acta Biomed. 2008;79(3):223-226.
37. Castricini R, Longo UG, De Benedetto M, et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial [published online ahead of print December 15, 2010]. Am J Sports Med.
38. Weber SC, Kauffman JI. Platelet-rich fibrin matrix in arthroscopic rotator cuff repair: prospective, randomized study. Abstract 43. Presented at 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons: New Orleans, LA; March 9-13, 2010.
39. de Vos RJ, Weir A, van Schie HT, et al. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA. 2010;303(2):144-149.
40. Hrnack SA, Barber FA, Hapa O. Rotator cuff repairs augmented by platelet rich plasma evaluated with MRI and clinical outcomes (SS-08). J Arthroscop Relat Res. 2010;26:e4-e5.
41. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010;38(2):255-262.
42. Smidt N, Assendelft WJ, van der Windt DA, Hay EM, Buchbinder R, Bouter LM. Corticosteroid injections for lateral epicondylitis: a systematic review. Pain. 2002;96(1-2):23-40. (Pubitemid 34270625)
43. Engebretsen L, Steffen K, Alsousou J, et al. IOC consensus paper on the use of platelet-rich plasma in sports medicine. Br J Sports Med. 2010;44(15):1072-1081.
44. 2011 Prohibited List. http://www.wada-ama.org/en/News-Center/Articles/ WADA-2011-Prohibited-List-Now-Published. Accessed October 15, 2010.