Antiapoptotic and antioxidant properties of orthosiphon stamineus benth (Cat's Whiskers): Intervention in the Bcl-2-mediated apoptotic pathway

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Abdelwahab, Siddig Ibrahim ^a   Mohan, Syam ^b   Mohamed Elhassan, Manal ^b   Al Mekhlafi, Nabil ^b   Mariod, Abdelbasit Adam ^c   Abdul, Ahmad Bustamam ^b   Abdulla, Mahmood Ameen ^a   Alkharfy, Khalid M ^d  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c Sudan University for Science and Technology   (Sudan)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; BETA CAROTENE; BUTANOL; CASPASE 3; CHLOROFORM; FLAVONOID; HEXANE; HYDROGEN PEROXIDE; METHANOL; ORTHOSIPHON STAMINEUS EXTRACT; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; WATER;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; MITOCHONDRION; ORTHOSIPHON; ORTHOSIPHON STAMINEUS; OXIDATION; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLVENT EXTRACTION;

EID: 79952225939     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2011/156765     Document Type: Article

References (41)

1. Cooper E. L., Drug discovery, CAM and natural products Evidence-Based Complementary and Alternative Medicine 2005 1 13 215 217
2. Cooper E. L., CAM, eCAM, bioprospecting: the 21st century p (Pubitemid 41399483)
3. Firenzuoli F., Gori L., Herbal medicine today: clinical and research issues Evidence-based Complementary and Alternative Medicine 2007 4 supplement 1 37 40
4. Rabe T., Van Staden J., Antibacterial activity of South African plants used for medicinal purposes Journal of Ethnopharmacology 1997 56 1 81 87 (Pubitemid 27182747)
5. Abdullah N. R., Ismail Z., Ismail Z., Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats Phytomedicine 2009 16 2-3 222 226
6. Adam Y., Somchit M. N., Sulaiman M. R., Nasaruddin A. A., Zuraini A., Bustamam A. A., Zakaria Z. A., Diuretic properties of Orthosiphon stamineus Benth Journal of Ethnopharmacology 2009 124 1 154 158
7. Ahmad M. N., Mee Sim M. Y., Cheen C. C., Shafiqul Islam A. K. M., Ismail Z., Surif M., Shakaff A. Y. MD., Lvova L., Disposable array sensor strip for quantification of sinensetin in Orthosiphon stamineus Benth samples Microchimica Acta 2008 163 1-2 113 119
8. Akowuah G. A., Zhari I., Determination of betulinic acid from Orthosiphon stamineus leaf extract in rat plasma Pharmazie 2008 63 11 788 790
9. Akowuah G. A., Zhari I., Norhayati I., Sadikun A., Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus Pharmaceutical Biology 2004 42 8 629 635 (Pubitemid 40364814)
10. Akowuah G. A., Zhari I., Norhayati I., Sadikun A., Khamsah S. M., Sinensetin, eupatorin, 3-hydroxy-5, 6, 7, 4 -tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia Food Chemistry 2004 87 4 559 566 (Pubitemid 38757568)
11. Akowuah G. A., Zhari I., Sadikun A., Norhayati I., HPTLC densitometric analysis of Orthosiphon stamineus leaf extracts and inhibitory effect on xanthine oxidase activity Pharmaceutical Biology 2006 44 1 65 70
12. Akowuah G. A., Zhari I., Sadikun A., Norhayati I., Sundram K., Khamsah M., Quantification of Betulinic acid in leaf extracts of Orthosiphon stamineus Journal of Tropical Medicinal Plants 2003 4 2 225 228
13. Ikawati Z., Wahyuono S., Maeyama K., Screening of several Indonesian medicinal plants for their inhibitory effect on histamine release from RBL-2H3 cells Journal of Ethnopharmacology 2001 75 2-3 249 256 (Pubitemid 32297741)
14. Awale S., Tezuka Y., Banskota A. H., Kadota S., Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship Biological and Pharmaceutical Bulletin 2003 26 4 468 473 (Pubitemid 39663591)
15. Hollman P. C. H., Katan M. B., Dietary flavonoids: intake, health effects and bioavailability Food and Chemical Toxicology 1999 37 9-10 937 942 (Pubitemid 29481795)
16. Yuliana N. D., Khatib A., Link-Struensee A. M. R., Ijzerman A. P., Rungkat-Zakaria F., Young H. C., Verpoorte R., Adenosine A receptor binding activity of methoxy flavonoids from Orthosiphon stamineus Planta Medica 2009 75 2 132 136
17. Olah N. K., Hanganu D., Oprean R., Mogoan C., Dubei N., Gocan S., Selective extraction of caffeic acid derivatives from Orthosiphon stamineus Benth. (Lamiaceae) leaves Journal of Planar ChromatographyModern TLC 2004 17 1 18 21 (Pubitemid 38386988)
18. Pietta P. G., Mauri P. L., Gardana C., Bruno A., High-performance liquid chromatography with diode-array ultraviolet detection of methoxylate flavones in Orthosiphon leaves Journal of Chromatography 1991 547 1-2 439 442
19. Awale S., Tezuka Y., Banskota A. H., Kouda K., Kyaw M. T., Kadota S., Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus Planta Medica 2002 68 3 286 288 (Pubitemid 34271005)
20. Dixon R. A., Xie D. E. Y., Sharma S. B., Proanthocyanidinsa final frontier in flavonoid research? New Phytologist 2005 165 1 9 28 (Pubitemid 40033162)
21. Gao DA. F., Zhang Y. J., Yang C. R., Chen KE. K., Jiang H. J., Phenolic antioxidants from green tea produced from Camellia taliensis Journal of Agricultural and Food Chemistry 2008 56 16 7517 7521
22. Mariod A. A., Ibrahim R. M., Ismail M., Ismail N., Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake Food Chemistry 2009 116 1 306 312
23. Kaur R., Arora S., Singh B., Antioxidant activity of the phenol rich fractions of leaves of Chukrasia tabularis A. Juss Bioresource Technology 2008 99 16 7692 7698
24. Quettier-Deleu C., Gressier B., Vasseur J., Dine T., Brunet C., Luyckx M., Cazin M., Cazin J. C., Bailleul F., Trotin F., Phenolic compounds and antioxidant activities of buckwheat (Fagopyrum esculentum Moench) hulls and flour Journal of Ethnopharmacology 2000 72 1-2 35 42
25. Hatano T., Kagawa H., Yasuhara T., Okuda T., Two new flavonoids and other constituents in licorice root: their relative astringency and radical scavenging effects Chemical and Pharmaceutical Bulletin 1988 36 6 2090 2097
26. Amarowicz R., Wanasundara U., Wanasundara J., Shahidi F., Antioxidant activity of ethanolic extracts of flaxseed in a -carotene-linoleate model system Journal of Food Lipids 1993 1 111 117
27. Weecharangsan W., Opanasopit P., Sukma M., Ngawhirunpat T., Sotanaphun U., Siripong P., Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.) Medical Principles and Practice 2006 15 4 281 287 (Pubitemid 43876741)
28. Chan E. W. C., Lim Y. Y., Chew Y. L., Antioxidant activity of Camellia sinensis leaves and tea from a lowland plantation in Malaysia Food Chemistry 2007 102 4 1214 1222 (Pubitemid 46178479)
29. Matthus B., Antioxidant activity of extracts obtained from residues of different oilseeds Journal of Agricultural and Food Chemistry 2002 50 12 3444 3452
30. Scholz E., Rimpler H., Proanthocyanidins from Krameria triandra root Planta Medica 1989 55 4 379 384 (Pubitemid 19203289)
31. Conde E., Moure A., Domnguez H., Paraj J. C., Fractionation of antioxidants from Autohydrolysis of barley husks Journal of Agricultural and Food Chemistry 2008 56 22 10651 10659
32. Hossain N. P., Ismail Z., Flavonoids and triterpenoids from the leaves of Orthosiphon stamineus Journal-Bangladesh Academy of Sciences 2005 29 1 41
33. Yang Y., Yue Y., Runwei Y., Guolin Z., Cytotoxic, apoptotic and antioxidant activity of the essential oil of Amomum tsao-ko Bioresource Technology 2010 101 11 4205 4211
34. Kumaran A., Joel Karunakaran R., Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus Food Chemistry 2006 97 1 109 114 (Pubitemid 41773946)
35. Sim K. S., Sri Nurestri A. M., Norhanom A. W., Phenolic content and antioxidant activity of Pereskia grandifolia Haw. (Cactaceae) extracts Pharmacognosy Magazine 2010 6 23 248 254
36. Wang B., Peng L., Zhu L., Ren P., Protective effect of total flavonoids from Spirodela polyrrhiza (L.) Schleid on human umbilical vein endothelial cell damage induced by hydrogen peroxide Colloids and Surfaces B: Biointerfaces 2007 60 1 36 40 (Pubitemid 47302293)
37. Dipietrantonio A. M., Hsieh T. C., Wu J. M., Activation of caspase 3 in HL-60 cells exposed to hydrogen peroxide Biochemical and Biophysical Research Communications 1999 255 2 477 482 (Pubitemid 29292285)
38. Mtrailler-Ruchonnet I., Pagano A., Carnesecchi S., Ody C., Donati Y., Barazzone Argiroffo C., Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway Free Radical Biology and Medicine 2007 42 7 1062 1074 (Pubitemid 46356899)
39. Zhuang S., Yan Y., Daubert R. A., Han J., Schnellmann R. G., ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells American Journal of Physiology 2007 292 1 F440 F447
40. Gross A., McDonnell J. M., Korsmeyer S. J., BCL-2 family members and the mitochondria in apoptosis Genes and Development 1999 13 15 1899 1911 (Pubitemid 29407357)
41. Aikawa R., Komuro I., Yamazaki T., Zou Y., Kudoh S., Tanaka M., Shiojima I., Hiroi Y., Yazaki Y., Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats Journal of Clinical Investigation 1997 100 7 1813 1821 (Pubitemid 27431340