A rapid and simple chemiluminescence method for screening levels of inosine and hypoxanthine in non-traumatic chest pain patients

Luminescence

Volumn 26, Issue 1, 2011, Pages 65-75

  Farthing, Don E ^a,b   Sica, Domenic ^a   Hindle, Michael ^b   Edinboro, Les ^c   Xi, Lei ^b   Gehr, Todd W B ^a   Gehr, Lynne ^a   Farthing, Christine A ^a   Larus, Terri L ^a   Fakhry, Itaf ^a   Karnes, H Thomas ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Acute cardiac ischemia; Biomarker; Chemiluminescence; Hypoxanthine; Inosine; Pholasin

Indexed keywords

CHEMILUMINESCENCE; DIAGNOSIS; DIRECT INJECTION; FREE RADICALS; PLASMA (HUMAN);

ACUTE CARDIAC ISCHEMIA; CARDIAC ISCHEMIA; CHEST PAIN; HUMAN PLASMAS; HYPOXANTHINE; INOSINE; MICROPLATES; PHOLASIN®; SCREENING LEVEL; SIMPLE++;

BIOMARKERS;

EID: 79952210040     PISSN: 15227235     EISSN: 15227243     Source Type: Journal    
DOI: 10.1002/bio.1187     Document Type: Article

References (27)

1. Naudziunas A, Jankauskiene L, Kalinauskiene E, Pilvinis V. Implementation of the patient education about cardiovascular risk factors into a daily routine of the Cardiology Unit of the hospital. Prev Med 2005;41(2):570-4. (Pubitemid 40732373)
2. Okrainec K, Banerjee DK, Eisenburg MJ. Coronary artery disease in the developing world. Am Heart J 2004;148(1):7-15. (Pubitemid 38900475)
3. Dorner T, Rieder A. Risk management of coronary heart diseaseprevention. Wiener Medizinische Wochenschrift 2004;154(11-12):257-65. (Pubitemid 38916203)
4. AHRQ. Evaluation of Technologies for Identifying Acute Cardiac Ischemia in Emergency Departments. Summary, Evidence Report/Technology Assessment: No. 26, AHRQ Publication 00-E031, Agency for Healthcare Research and Quality, Rockville MD, 2000.
5. Beyerle K. POC testing of cardiac markers enhances ED care. Nurs Mgmt 2002;33(9):37-9.
6. Apple FS, Anderson FP, Collinson P, Jesse RL, Kontos MC, Levitt MA, Miller EA, Murakami MM. Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction. Clin Chem 2000;46(10):1604-9.
7. Wu AHB, Smith A, Christenson RH, Murakami MM, Apple FS. Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction. Clin Chim Acta 2004;346:211-9. (Pubitemid 38901053)
8. Bunk DM, Dalluge JJ, Welch MJ. Heterogeneity in human cardiac troponin I standards. Anal Biochem 2000;284:191-200.
9. Mayr BM, Kohlbacher O, Reinert K, Sturm M, Gröpl C, Lange E, Klein C, Huber CG. Absolute myoglobin quantitation in serum by combining two-dimensional liquid chromatography-electrospray ionization mass spectrometry and novel data analysis algorithms. J Proteome Res 2006;5:414-21. (Pubitemid 43222310)
10. Apple FS, Christenson RH, Valdes Jr R, Andriak AJ, Berg A, Duh S, Feng Y, Jortani SA, Johnson NA, Koplen B, Mascotti K, Wu AH. Simultaneous rapid measurement of whole blood myoglobin, creatine kinase-MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction. Clin Chem 1999;45(2):199-205.
11. Heeschen C, Goldmann BU, Langenbrink L, Matschuck G, Hamm CW. Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain. Clin Chem 1999;45(10):1789-96. (Pubitemid 29477337)
12. McCord J, Nowak RM, Mcculloguh PA, Foreback C, Borzak S, Trokarski G, Tomlanovich MC, Jacobsen G, Weaver WD. Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 2001;104:1483-8. (Pubitemid 32917339)
13. Mistovich JJ, Hafen BQ, Karren KJ, Karren KS. Prehospital Emergency Care, 7th edn. Brady/Prentice Hall Health Publishers: Upper Saddle River, NJ, 2003.
14. Farthing D. Investigation of inosine and hypoxanthine as biomarkers of cardiac ischemia in plasma of non-traumatic chest pain patients and a rapid analytical system for assessment. Dissertation. Virginia Commonwealth University, 2008.
15. Feng JD, Yeung PK. A simple high-performance liquid chromatography assay for simultaneous measurement of adenosine, guanosine, and the oxypurine metabolites in plasma. Ther Drug Monit 2000;22(2):177-83. (Pubitemid 30196822)
16. Farthing D, Sica D, Gehr T, Wilson B, Fakhry I, Larus T, Farthing C, Karnes HT. A simple and sensitive HPLC method for determination of inosine and hypoxanthine in human plasma from healthy volunteers and patients presenting with chest pain and potential acute cardiac ischemia. J Chromatogr B 2007;854(1-2):158-64. (Pubitemid 46962377)
17. Boulieu R, Bory C, Baltassat P, Gonnet C. Hypoxanthine and xanthine levels determined by high-performance liquid chromatography in plasma, erythrocyte, and urine samples from healthy subjects: the problem of hypoxanthine level evolution as a function of time. Analyt Biochem 1983;129:398-404.
18. Boulieu R, Bory C, Baltassat P, Divry P. Hypoxanthine and xanthine concentrations determined by high performance liquid chromatography in biological fluids from patients with xanthinuria. Clin Chim Acta 1984;142:83-9. (Pubitemid 14068953)
19. Scott MD, Baudendistel LJ, Dahms TE. Rapid separation of creatine, phosphocreatine and adenosine metabolites by ion-pair reversedphase high-performance liquid chromatography in plasma and cardiac tissue. J Chromatogr 1992;576(1):149-54.
20. Furst W, Hallstrom S. Simultaneous determination of myocardial nucleotides, nucleosides, purine bases and creatine phosphate by ion-pair high-performance liquid chromatography. J Chromatogr 1992;578(1):39-44.
21. Tavazzi B, Lazzarino G, Leione P, Amorini AM, Bellia F, Janson CG, Di PV, Ceccarelli L, Donzelli S, Francis JS, Giardina B. Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem 2005;38(11):997-1008. (Pubitemid 41606797)
22. Jabs CM, Neglen P, Eklof B, Thomas EJ. Adenosine, inosine, and hypoxanthine/xanthine measured in tissue and plasma by a luminescence method. Clin Chem 1990;36(1):81-7.
23. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Murat T, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial infarction. J Clin Invest 2008;118(10):3503-12.
24. Knight J. Reactions of pholasin with superoxide and peroxidases: applications to cellular chemiluminescence. In Bioluminescence and Chemiluminescence. Perspectives for the 21st Century, Roda A, Kricka LJ, Stanley PE (eds). Wiley, Chichester, 1999;251-4.
25. Muller T, Campbell AK. The chromophore of pholasin: a highly luminescent protein. J Biolumin Chemilumin 1990;5:25-30.
26. Knight J. The piddock and the immunologist. Immunol News 1997;4(1):26-31.
27. Schlesinger N, Norquist JM, Watson DJ. Serum urate during acute gout. J Rheumatol 2009;36(6):1287-9.