Chemoprevention with aqueous extract of Butea monosperma flowers results in normalization of nuclear morphometry and inhibition of a proliferation marker in liver tumors

Phytotherapy Research

Volumn 25, Issue 3, 2011, Pages 324-328

  Mathan, G ^a,c   Fatima, G ^a   Saxena, A K ^b   Chandan, B K ^b   Jaggi, B S ^b   Gupta, B D ^b   Qazi, G N ^b   Balasundaram, C ^c   Rajan, K D Anand ^d   Kumar, V L ^d   Kumar, Vijay ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c BHARATHIDASAN UNIVERSITY   (India)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Butea monosperma; Flower extract; HBx; Hepatoprotection; Nuclear morphometry; Rps27a; Transgenic mice

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BUTANOL; BUTEA MONOSPERMA EXTRACT; CARBON TETRACHLORIDE; GLUTATHIONE; MALONALDEHYDE; PLANT EXTRACT; RIBOSOMAL PROTEIN S27A ANTIBODY; RIBOSOME PROTEIN; SILYMARIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VASCULOTROPIN; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BUTEA MONOSPERMA; CELL NUCLEUS; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOARCHITECTURE; DISEASE MARKER; DOWN REGULATION; DRUG EFFECT; FLOWER; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER PROTECTION; MORPHOMETRICS; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BUTEA; CARBON TETRACHLORIDE; CELL NUCLEUS; CELL PROLIFERATION; FLOWERS; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; BUTEA MONOSPERMA; FABACEAE; MUS MUSCULUS; RATTUS;

EID: 79952204899     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3249     Document Type: Article

References (26)

1. Buege JA, Aust SD. 1978. Microsomal lipid peroxidation. Methods Enzymol 52: 302-310.
2. Burlia DA, Khadeb AB. 2007. A comprehensive review on Butea monosperma (Lam.) Kuntze. Pharmacogn Rev 1: 333-337.
3. Carmeliet P. 2005. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 (Suppl 3): 4-10. (Pubitemid 41680947)
4. Cheng AS, Chan HL, To KF et al. 2004. Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. Int J Oncol 24: 853-860.
5. Choedon T, Mathan G, Arya S, Kumar VL, Kumar V. 2006. Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma. World J Gastroenterol 12: 2517-2522.
6. Choedon T, Shukla SK, Kumar V. 2010. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. J Ethnopharmacol 129: 208-213.
7. Colleoni M, Rocca A, Sandri MT et al. 2002. Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 13: 73-80. (Pubitemid 34436728)
8. Ellman GL. 1959. Tissue sulfhydral groups. Arch Biochem Biophys 82: 70-77.
9. Gupta SR, Ravindranath B, Seshadri TR. 1970. The glucosides of Butea monosperma. Phytochemistry 9: 2231-2235.
10. Hemalswarya S, Doble M. 2006. Potential synergism of natural products in the treatment of cancer. Phytother Res 20: 239-249.
11. Ikeguchi M, Sato N, Hirooka Y, Kaibara N. 1998. Computerized nuclear morphometry of hepatocellular carcinoma and its relation to proliferative activity. J Surg Oncol 68: 225-230. (Pubitemid 28390177)
12. Kiso Y, Tohkin M, Hikino H. 1983. Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes. Planta Med 49: 222-225. (Pubitemid 14220883)
13. Kondoh N, Shuda M, Tanaka K,Wakatsuki T, Hada A, Yamamoto M. 2001. Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma. Anticancer Res 21: 2429-2433. (Pubitemid 33054406)
14. Lakhtakia R, Kumar V, Reddi H, Mathur M, Dattagupta S, Panda SK. 2003. Hepatocellular carcinoma in a hepatitis B 'x' transgenic mouse model: A sequential pathological evaluation. J Gastroenterol Hepatol 18: 80-91.
15. Li M, Tang ZY, Zhou G, Lui YK, Ye SL. 1998. Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer Res 17: 13-17. (Pubitemid 28215959)
16. Murti PBR, Seshadri TR. 1941. The glycosidic components of the flowers of Butea frondosa. Proc Indian Acad Sci A 13: 395-398.
17. Nazimuddin SK, Quamaruddin S, Tahera SS, Ashfaquddin M, Rehana A, Iqbal Ali M. 1981. Protective effect of Gul-E-Teesu (Butea monosperma (Lam) flowers) in experimental liver injury. Bull Islamic Med 1: 448-453.
18. Patel S, O'Gorman P. 1975. Serum enzyme levels in alcoholism and drug dependency. J Clin Pathol 28: 414-417.
19. Poon RT, Lau C, Pang R, Ng KK, Yuen J, Fan ST. 2007. High serum vascular endothelial growth factor levels predict poor prognosis after radio frequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies. Ann Surg Oncol 14: 1835-1845. (Pubitemid 46870942)
20. Saxena AK, Gupta BD, Kapahi BK et al. 2006. A Pharmaceutical Composition Useful for the Treatment of Hepatocellular Carcinoma WO 2006/126067 A1. World Intellectual Property Organization, Geneva, Switzerland.
21. Sehrawat A, Sultana S. 2006. Chemoprevention by Butea monosperma of hepatic carcinogenesis and oxidative damage in male Wistar rats. Asian Pacif J Cancer Prev 7: 140-148.
22. Shuda M, Kondoh N, Tanaka K et al. 2000. Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Anticancer Res 20: 2489-2494. (Pubitemid 30614457)
23. Singh M, Kumar V. 2003. Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma. Rev Med Virol 13: 243-253.
24. Subramoniam, A, Pushpangadan P. 1999. Development of phytomedicines for liver diseases. Indian J Pharmacol 31: 166-175. (Pubitemid 29317731)
25. Wagner H, Geyer B, Fiebig M, Kiso Y, Hikino H. 1986. Isobutrin and butrin, the antihepatotoxic principles of Butea monosperma flowers. Planta Med 12: 77-79. (Pubitemid 16110485)
26. Yang ZF, Poon RT. 2008. Vascular changes in hepatocellular carcinoma. Anat Rec 291: 721-734.