A facile and rapid automated synthesis of 3'-deoxy-3'-[ 18F]fluorothymidine

Applied Radiation and Isotopes

Volumn 68, Issue 9, 2010, Pages 1734-1739

  Tang, Ganghua ^a,c   Tang, Xiaolan ^b   Wen, Fuhua ^a   Wang, Mingfang ^c   Li, Baoyuan ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

18F FLT; Fully automated synthesis; One pot; Proliferation tracer; Thymidine

Indexed keywords

[ 18F]FLT; AUTOMATED SYNTHESIS; ONE POT; PROLIFERATION TRACER; THYMIDINE;

AUTOMATION; FLUORINE; PURIFICATION;

SYNTHESIS (CHEMICAL);

3' FLUOROTHYMIDINE F 18; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 3' FLUOROTHYMIDINE; RADIOPHARMACEUTICAL AGENT;

ARTICLE; AUTOMATION; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PURIFICATION; QUALITY CONTROL; REACTION TIME; SYNTHESIS; CHEMISTRY; ISOLATION AND PURIFICATION; ISOTOPE LABELING; METHODOLOGY; ROBOTICS;

DIDEOXYNUCLEOSIDES; ISOTOPE LABELING; RADIOPHARMACEUTICALS; ROBOTICS;

EID: 79952197287     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2010.04.010     Document Type: Article

References (16)

1. 18F]FLT-PET in oncology: current status and opportunities. Eur. J. Nucl. Med. Mol. Imaging 2004, 31:1659-1672.
2. 18F]FLT preparation. J. Radioanal. Nucl. Chem. 2002, 251:55-58.
3. 18F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules. Cancer Res. 2002, 62:3331-3334.
4. 18F]FLT for imaging of cellular proliferation in vivo. Nucl. Med. Biol. 2000, 27:143-156.
5. 18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent. Eur. J. Nucl. Med. Mol. Imaging 2007, 34:1406-1409.
6. 18F]fluorothymidine by nucleophilic fluorination in various alcohol solvents. J. Labelled Compd. Radiopharm. 2008, 51:80-82.
7. 18F]FLT). J. Radioanal. Nucl. Chem. 2000, 243:843-846.
8. 18F]FLT). Nucl. Med. Biol. 2002, 29:263-273.
9. 18F]-3'-deoxy-3'-fluorothymidine using a nosylate precursor in ionic liquid ([bmim][OTf]). J. Labelled Compd. Radiopharm. 2003, 46:S122.
10. 18F]FLT) in ionic liquid, [bmim][OTf]. J. Labelled Compd. Radiopharm 2006, 49:287-293.
11. 18F]fluorothymidine. Nucl. Med. Biol. 2004, 31:803-809.
12. 18F]fluoromisonidazole. Nucl. Med. Biol. 2005, 32:553-558.
13. Tang X., Tang G., Liao W. Simple and rapid analysis of residual aminopolyether (K222) levels in 18F-labeled imaging agents. Nucl. Technol. 2008, 31(11):846-849. (in Chinese).
14. 18F]fluorothymidine using three precursors. Appl. Radiat. Isot. 2006, 64:187-193.
15. 18F]fluorothy-midine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine. J. Labelled Cpd. Radiopharm. 2000, 43:1211-1218.
16. 18F]fluorothymidine using (5'-O-dimethoxytrityl)-2'-deoxy-3'-O-nosyl-Β-d-threo-pentofuranosyl) thymine and its 3-N-BOC-protected analogue as a labeling precursor. Nucl. Med. Biol. 2003, 30:151-157.