메뉴 건너뛰기




Volumn 352, Issue 1, 2011, Pages 104-115

The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo

Author keywords

7SK RNA; BCDIN3; Bicoid; Translation repression

Indexed keywords

ARGONAUTE 2 PROTEIN; INITIATION FACTOR 4E; MESSENGER RNA; POLYADENYLIC ACID BINDING PROTEIN; PROTEIN BIN3; RNA METHYLTRANSFERASE; UNCLASSIFIED DRUG;

EID: 79952190147     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.01.017     Document Type: Article
Times cited : (20)

References (56)
  • 1
    • 0032032823 scopus 로고    scopus 로고
    • Protein methylation: a signal event in post-translational modification
    • Aletta J.M., Cimato T.R., Ettinger M.J. Protein methylation: a signal event in post-translational modification. Trends Biochem. Sci. 1998, 23:89-91.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 89-91
    • Aletta, J.M.1    Cimato, T.R.2    Ettinger, M.J.3
  • 2
    • 34250859489 scopus 로고    scopus 로고
    • Protein arginine methyltransferases: from unicellular eukaryotes to humans
    • Bachand F. Protein arginine methyltransferases: from unicellular eukaryotes to humans. Euk. Cell 2007, 6:889-898.
    • (2007) Euk. Cell , vol.6 , pp. 889-898
    • Bachand, F.1
  • 3
    • 66049098191 scopus 로고    scopus 로고
    • 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development
    • Barboric M., Lenasi T., Chen H., Johansen E.B., Guo S., Peterlin B.M. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc. Natl Acad. Sci. USA 2009, 106:7798-7803.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 7798-7803
    • Barboric, M.1    Lenasi, T.2    Chen, H.3    Johansen, E.B.4    Guo, S.5    Peterlin, B.M.6
  • 4
    • 58149295717 scopus 로고    scopus 로고
    • Protein arginine methylation in mammals: who, what, and why
    • Bedford M.T., Clarke S.G. Protein arginine methylation in mammals: who, what, and why. Mol. Cell 2009, 33:1-13.
    • (2009) Mol. Cell , vol.33 , pp. 1-13
    • Bedford, M.T.1    Clarke, S.G.2
  • 5
    • 20844450998 scopus 로고    scopus 로고
    • Arginine methylation an emerging regulator of protein function
    • Bedford M.T., Richard S. Arginine methylation an emerging regulator of protein function. Mol. Cell 2005, 18:263-272.
    • (2005) Mol. Cell , vol.18 , pp. 263-272
    • Bedford, M.T.1    Richard, S.2
  • 6
    • 19444368782 scopus 로고    scopus 로고
    • The Drosophila shell game: patterning genes and morphological change
    • Berg C.A. The Drosophila shell game: patterning genes and morphological change. Trends Genet. 2005, 21:346-355.
    • (2005) Trends Genet. , vol.21 , pp. 346-355
    • Berg, C.A.1
  • 8
    • 33847660443 scopus 로고    scopus 로고
    • An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    • Bischof J., Maeda R.K., Hediger M., Karch F., Basler K. An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl Acad. Sci. USA 2007, 104:3312-3317.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3312-3317
    • Bischof, J.1    Maeda, R.K.2    Hediger, M.3    Karch, F.4    Basler, K.5
  • 9
    • 69949145541 scopus 로고    scopus 로고
    • Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development
    • Blagden S.P., Gatt M.K., Archambault V., Lada K., Ichihara K., Lilley K.S., Inoue Y.H., Glover D.M. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev. Biol. 2009, 334:186-197.
    • (2009) Dev. Biol. , vol.334 , pp. 186-197
    • Blagden, S.P.1    Gatt, M.K.2    Archambault, V.3    Lada, K.4    Ichihara, K.5    Lilley, K.S.6    Inoue, Y.H.7    Glover, D.M.8
  • 10
    • 0037133254 scopus 로고    scopus 로고
    • Transcription: surprising role for an elusive small nuclear RNA
    • Blencowe B.J. Transcription: surprising role for an elusive small nuclear RNA. Curr. Biol. 2002, 12:R147-R149.
    • (2002) Curr. Biol. , vol.12
    • Blencowe, B.J.1
  • 11
    • 18844397041 scopus 로고    scopus 로고
    • A new paradigm for translational control: inhibition via 5′-3′ mRNA tethering by Bicoid and the eIF4E cognate 4EHP
    • Cho P.F., Poulin F., Cho-Park Y.A., Cho-Park I.B., Chicoine J.D., Lasko P., Sonenberg N. A new paradigm for translational control: inhibition via 5′-3′ mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 2005, 121:411-423.
    • (2005) Cell , vol.121 , pp. 411-423
    • Cho, P.F.1    Poulin, F.2    Cho-Park, Y.A.3    Cho-Park, I.B.4    Chicoine, J.D.5    Lasko, P.6    Sonenberg, N.7
  • 12
    • 37849046959 scopus 로고    scopus 로고
    • Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila
    • Clouse K.N., Ferguson S.B., Schupbach T. Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila. Dev. Biol. 2008, 313:713-724.
    • (2008) Dev. Biol. , vol.313 , pp. 713-724
    • Clouse, K.N.1    Ferguson, S.B.2    Schupbach, T.3
  • 13
    • 0023679744 scopus 로고
    • The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
    • Driever W., Nüsslein-Volhard C. The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 1988, 54:95-104.
    • (1988) Cell , vol.54 , pp. 95-104
    • Driever, W.1    Nüsslein-Volhard, C.2
  • 14
    • 0024569785 scopus 로고
    • The bicoid protein is a positive regulator of hunchback transcription in the Drosophila embryo
    • Driever W., Nüsslein-Volhard C. The bicoid protein is a positive regulator of hunchback transcription in the Drosophila embryo. Nature 1989, 337:138-143.
    • (1989) Nature , vol.337 , pp. 138-143
    • Driever, W.1    Nüsslein-Volhard, C.2
  • 15
    • 0024323615 scopus 로고
    • Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the Bicoid morphogen
    • Driever W., Thoma G., Nüsslein-Volhard C. Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the Bicoid morphogen. Nature 1989, 340:363-367.
    • (1989) Nature , vol.340 , pp. 363-367
    • Driever, W.1    Thoma, G.2    Nüsslein-Volhard, C.3
  • 16
    • 0030059840 scopus 로고    scopus 로고
    • RNA recognition and translational regulation by a homeodomain protein
    • Dubnau J., Struhl G. RNA recognition and translational regulation by a homeodomain protein. Nature 1996, 379:694-699.
    • (1996) Nature , vol.379 , pp. 694-699
    • Dubnau, J.1    Struhl, G.2
  • 17
    • 70449638286 scopus 로고    scopus 로고
    • The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA
    • Duncan K.E., Strein C., Hentze M.W. The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Mol. Cell 2009, 36:571-582.
    • (2009) Mol. Cell , vol.36 , pp. 571-582
    • Duncan, K.E.1    Strein, C.2    Hentze, M.W.3
  • 19
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat. Rev. 2008, 9:102-114.
    • (2008) Nat. Rev. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 20
    • 0025078994 scopus 로고
    • The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development
    • Finkelstein R., Perrimon N. The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 1990, 346:485-488.
    • (1990) Nature , vol.346 , pp. 485-488
    • Finkelstein, R.1    Perrimon, N.2
  • 21
    • 39849085276 scopus 로고    scopus 로고
    • RNA immunoprecipitation for determining RNA-protein associations in vivo. Current protocols in molecular biology/edited by Frederick M. Ausubel et al., Chapter 27, Unit 27 24.
    • Gilbert, C., Svejstrup, J.Q., 2006. RNA immunoprecipitation for determining RNA-protein associations in vivo. Current protocols in molecular biology/edited by Frederick M. Ausubel et al., Chapter 27, Unit 27 24.
    • (2006)
    • Gilbert, C.1    Svejstrup, J.Q.2
  • 22
    • 0035205012 scopus 로고    scopus 로고
    • Establishment of dorsal-ventral polarity of the Drosophila egg requires capicua action in ovarian follicle cells
    • Goff D.J., Nilson L.A., Morisato D. Establishment of dorsal-ventral polarity of the Drosophila egg requires capicua action in ovarian follicle cells. Development (Cambridge, England) 2001, 128:4553-4562.
    • (2001) Development (Cambridge, England) , vol.128 , pp. 4553-4562
    • Goff, D.J.1    Nilson, L.A.2    Morisato, D.3
  • 24
    • 61349167072 scopus 로고    scopus 로고
    • Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep
    • Harbison S.T., Carbone M.A., Ayroles J.F., Stone E.A., Lyman R.F., Mackay T.F. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat. Genet. 2009, 41:371-375.
    • (2009) Nat. Genet. , vol.41 , pp. 371-375
    • Harbison, S.T.1    Carbone, M.A.2    Ayroles, J.F.3    Stone, E.A.4    Lyman, R.F.5    Mackay, T.F.6
  • 25
    • 4143065974 scopus 로고    scopus 로고
    • Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila
    • Hwa J.J., Zhu A.J., Hiller M.A., Kon C.Y., Fuller M.T., Santel A. Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. FEBS Lett. 2004, 572:141-146.
    • (2004) FEBS Lett. , vol.572 , pp. 141-146
    • Hwa, J.J.1    Zhu, A.J.2    Hiller, M.A.3    Kon, C.Y.4    Fuller, M.T.5    Santel, A.6
  • 26
    • 67650249494 scopus 로고    scopus 로고
    • MiR-184 has multiple roles in Drosophila female germline development
    • Iovino N., Pane A., Gaul U. miR-184 has multiple roles in Drosophila female germline development. Dev. Cell 2009, 17:123-133.
    • (2009) Dev. Cell , vol.17 , pp. 123-133
    • Iovino, N.1    Pane, A.2    Gaul, U.3
  • 28
    • 33845468254 scopus 로고    scopus 로고
    • ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage
    • Katzenberger R.J., Marengo M.S., Wassarman D.A. ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage. Mol. Cell. Biol 2006, 26:9256-9267.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 9256-9267
    • Katzenberger, R.J.1    Marengo, M.S.2    Wassarman, D.A.3
  • 29
    • 44149086912 scopus 로고    scopus 로고
    • Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP
    • Kawahara H., Imai T., Imataka H., Tsujimoto M., Matsumoto K., Okano H. Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J. Cell Biol. 2008, 181:639-653.
    • (2008) J. Cell Biol. , vol.181 , pp. 639-653
    • Kawahara, H.1    Imai, T.2    Imataka, H.3    Tsujimoto, M.4    Matsumoto, K.5    Okano, H.6
  • 31
    • 0343247787 scopus 로고    scopus 로고
    • Mechanism and Bicoid-dependent control of hairy stripe 7 expression in the posterior region of the Drosophila embryo
    • La Rosee A., Hader T., Taubert H., Rivera-Pomar R., Jackle H. Mechanism and Bicoid-dependent control of hairy stripe 7 expression in the posterior region of the Drosophila embryo. EMBO J. 1997, 16:4403-4411.
    • (1997) EMBO J. , vol.16 , pp. 4403-4411
    • La Rosee, A.1    Hader, T.2    Taubert, H.3    Rivera-Pomar, R.4    Jackle, H.5
  • 32
    • 64749109224 scopus 로고    scopus 로고
    • Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation
    • Lee Y.H., Stallcup M.R. Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol. Endo. (Baltimore, MD) 2009, 23:425-433.
    • (2009) Mol. Endo. (Baltimore, MD) , vol.23 , pp. 425-433
    • Lee, Y.H.1    Stallcup, M.R.2
  • 33
    • 0025366952 scopus 로고
    • Effects of ectopic expression of caudal during Drosophila development
    • Mlodzik M., Gibson G., Gehring W.J. Effects of ectopic expression of caudal during Drosophila development. Development (Cambridge, England) 1990, 109:271-277.
    • (1990) Development (Cambridge, England) , vol.109 , pp. 271-277
    • Mlodzik, M.1    Gibson, G.2    Gehring, W.J.3
  • 34
    • 0033118337 scopus 로고    scopus 로고
    • Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo
    • Niessing D., Dostatni N., Jackle H., Rivera-Pomar R. Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo. EMBO J. 1999, 18:1966-1973.
    • (1999) EMBO J. , vol.18 , pp. 1966-1973
    • Niessing, D.1    Dostatni, N.2    Jackle, H.3    Rivera-Pomar, R.4
  • 35
    • 0033853989 scopus 로고    scopus 로고
    • Homeodomain position 54 specifies transcriptional versus translational control by Bicoid
    • Niessing D., Driever W., Sprenger F., Taubert H., Jackle H., Rivera-Pomar R. Homeodomain position 54 specifies transcriptional versus translational control by Bicoid. Mol. Cell 2000, 5:395-401.
    • (2000) Mol. Cell , vol.5 , pp. 395-401
    • Niessing, D.1    Driever, W.2    Sprenger, F.3    Taubert, H.4    Jackle, H.5    Rivera-Pomar, R.6
  • 36
    • 0036790664 scopus 로고    scopus 로고
    • Bicoid associates with the 5′-cap-bound complex of caudal mRNA and represses translation
    • Niessing D., Blanke S., Jackle H. Bicoid associates with the 5′-cap-bound complex of caudal mRNA and represses translation. Genes Dev. 2002, 16:2576-2582.
    • (2002) Genes Dev. , vol.16 , pp. 2576-2582
    • Niessing, D.1    Blanke, S.2    Jackle, H.3
  • 37
    • 45749126026 scopus 로고    scopus 로고
    • C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis
    • Nykamp K., Lee M.H., Kimble J. C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA (New York, N.Y) 2008, 14:1378-1389.
    • (2008) RNA (New York, N.Y) , vol.14 , pp. 1378-1389
    • Nykamp, K.1    Lee, M.H.2    Kimble, J.3
  • 39
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura K., Ishizuka A., Siomi H., Siomi M.C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 2004, 18:1655-1666.
    • (2004) Genes Dev. , vol.18 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 41
    • 0028722641 scopus 로고
    • Imaging neuronal subsets and other cell types in whole mount Drosophila embryos and larvae using antibody probes
    • Academic Press, New York, L.S.B. Goldstein, E. Fryberg (Eds.)
    • Patel N.H. Imaging neuronal subsets and other cell types in whole mount Drosophila embryos and larvae using antibody probes. Methods in Cell Biology 1994, 44. Academic Press, New York. L.S.B. Goldstein, E. Fryberg (Eds.).
    • (1994) Methods in Cell Biology , pp. 44
    • Patel, N.H.1
  • 42
    • 0026649985 scopus 로고
    • Bicoid and the terminal system activate tailless expression in the early Drosophila embryo
    • Pignoni F., Steingrimsson E., Lengyel J.A. Bicoid and the terminal system activate tailless expression in the early Drosophila embryo. Development (Cambridge, England) 1992, 115:239-251.
    • (1992) Development (Cambridge, England) , vol.115 , pp. 239-251
    • Pignoni, F.1    Steingrimsson, E.2    Lengyel, J.A.3
  • 44
    • 0030281034 scopus 로고    scopus 로고
    • From gradients to stripes in Drosophila embryogenesis: filling in the gaps
    • Rivera-Pomar R., Jackle H. From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet. 1996, 12:478-483.
    • (1996) Trends Genet. , vol.12 , pp. 478-483
    • Rivera-Pomar, R.1    Jackle, H.2
  • 46
    • 77955122233 scopus 로고    scopus 로고
    • A stimulatory role for the La-related protein 4B in translation. RNA (New York, N.Y)
    • Schaffler, K., Schulz, K., Hirmer, A., Wiesner, J., Grimm, M., Sickmann, A., Fischer, U., A stimulatory role for the La-related protein 4B in translation. RNA (New York, N.Y) 16, 1488-1499.
    • , vol.16 , pp. 1488-1499
    • Schaffler, K.1    Schulz, K.2    Hirmer, A.3    Wiesner, J.4    Grimm, M.5    Sickmann, A.6    Fischer, U.7
  • 47
    • 34547820319 scopus 로고    scopus 로고
    • Transcriptional networking captures the 7SK RNA 5′-gamma-methyltransferase
    • Shuman S. Transcriptional networking captures the 7SK RNA 5′-gamma-methyltransferase. Mol. Cell 2007, 27:517-519.
    • (2007) Mol. Cell , vol.27 , pp. 517-519
    • Shuman, S.1
  • 48
    • 11844304193 scopus 로고    scopus 로고
    • Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster
    • Singh N., Zhu W., Hanes S.D. Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Dev. Biol. 2005, 278:242-254.
    • (2005) Dev. Biol. , vol.278 , pp. 242-254
    • Singh, N.1    Zhu, W.2    Hanes, S.D.3
  • 49
    • 0025865166 scopus 로고
    • Transcriptional regulation of a pair-rule stripe in Drosophila
    • Small S., Kraut R., Hoey T., Warrior R., Levine M. Transcriptional regulation of a pair-rule stripe in Drosophila. Genes Dev. 1991, 5:827-839.
    • (1991) Genes Dev. , vol.5 , pp. 827-839
    • Small, S.1    Kraut, R.2    Hoey, T.3    Warrior, R.4    Levine, M.5
  • 50
    • 60149091189 scopus 로고    scopus 로고
    • Regulation of translation initiation in eukaryotes: mechanisms and biological targets
    • Sonenberg N., Hinnebusch A.G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 2009, 136:731-745.
    • (2009) Cell , vol.136 , pp. 731-745
    • Sonenberg, N.1    Hinnebusch, A.G.2
  • 51
    • 0025361358 scopus 로고
    • Two gap genes mediate maternal terminal pattern information in Drosophila
    • Weigel D., Jurgens G., Klingler M., Jackle H. Two gap genes mediate maternal terminal pattern information in Drosophila. Science 1990, 248:495-498.
    • (1990) Science , vol.248 , pp. 495-498
    • Weigel, D.1    Jurgens, G.2    Klingler, M.3    Jackle, H.4
  • 52
    • 77449119756 scopus 로고    scopus 로고
    • A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP
    • Xue Y., Yang Z., Chen R., Zhou Q. A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. Nuc. Acids Res. 2010, 38:360-369.
    • (2010) Nuc. Acids Res. , vol.38 , pp. 360-369
    • Xue, Y.1    Yang, Z.2    Chen, R.3    Zhou, Q.4
  • 53
    • 0028939021 scopus 로고
    • Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    • Yu Y., Pick L. Non-periodic cues generate seven ftz stripes in the Drosophila embryo. Mech. Dev. 1995, 50:163-175.
    • (1995) Mech. Dev. , vol.50 , pp. 163-175
    • Yu, Y.1    Pick, L.2
  • 54
    • 0028284411 scopus 로고
    • Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos
    • Zapata J.M., Martinez M.A., Sierra J.M. Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos. J. Biol. Chem. 1994, 269:18047-18052.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18047-18052
    • Zapata, J.M.1    Martinez, M.A.2    Sierra, J.M.3
  • 55
    • 0034696632 scopus 로고    scopus 로고
    • Identification of Drosophila Bicoid-interacting proteins using a custom two-hybrid selection
    • Zhu W., Hanes S.D. Identification of Drosophila Bicoid-interacting proteins using a custom two-hybrid selection. Gene 2000, 245:329-339.
    • (2000) Gene , vol.245 , pp. 329-339
    • Zhu, W.1    Hanes, S.D.2
  • 56
    • 0034851860 scopus 로고    scopus 로고
    • Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity
    • Zhu W., Foehr M., Jaynes J.B., Hanes S.D. Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity. Dev. Genes Evol. 2001, 211:109-117.
    • (2001) Dev. Genes Evol. , vol.211 , pp. 109-117
    • Zhu, W.1    Foehr, M.2    Jaynes, J.B.3    Hanes, S.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.