Novel bioactive hydrophobic gentamicin carriers for the treatment of intracellular bacterial infections

Acta Biomaterialia

Volumn 7, Issue 4, 2011, Pages 1599-1608

  Imbuluzqueta, Edurne ^a   Elizondo, Elisa ^b,c   Gamazo, Carlos ^a   Moreno Calvo, Evelyn ^b,c   Veciana, Jaume ^b,c   Ventosa, Nora ^b,c   Blanco Prieto, María J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA ICMAB CSIC   (Spain)

^c BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Drug delivery systems; Gentamicin; Hydrophobic ion pairing; Intracellular pathogens; Supercritical fluids

Indexed keywords

BACTERIA; CONTROLLED DRUG DELIVERY; EFFLUENT TREATMENT; EMULSIFICATION; ENCAPSULATION; IONS; PATHOGENS; PRECIPITATION (CHEMICAL); SUPERCRITICAL FLUIDS; TARGETED DRUG DELIVERY;

BACTERIAL INFECTIONS; BIOACTIVES; DRUG-DELIVERY SYSTEMS; GENTAMICIN; HYDROPHOBIC ION PAIRING; HYDROPHOBICS; INTRACELLULAR BACTERIA; INTRACELLULAR PATHOGENS; ION-PAIRING; PLGA NANOPARTICLES;

HYDROPHOBICITY;

DOCUSATE SODIUM; GENTAMICIN; GENTAMICIN BIS(2 ETHYLHEXYL)SULFOSUCCINATE SODIUM; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; BRUCELLA MELITENSIS; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG STRUCTURE; ENCAPSULATION; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTRACELLULAR BACTERIUM; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; ZETA POTENTIAL;

BACTERIA (MICROORGANISMS); BRUCELLA MELITENSIS;

EID: 79952189940     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.11.031     Document Type: Article

References (41)

1. A. Haas The phagosome: compartment with a license to kill Traffic 8 2007 311 330 (Pubitemid 46421614)
2. S. Carryn, H. Chanteux, C. Seral, M.P. Mingeot-Leclercq, F. Van Bambeke, and P.M. Tulkens Intracellular pharmacodynamics of antibiotics Infect Dis Clin North Am 17 2003 615 634 (Pubitemid 38029156)
3. B.D. Davis Mechanism of bactericidal action of aminoglycosides Microbiol Rev 51 1987 341 350 (Pubitemid 17150318)
4. G.G. Zhanel, and W.A. Craig Pharmacokinetic contributions to postantibiotic effects. Focus on aminoglycosides Clin Pharmacokinet 27 1994 377 392 (Pubitemid 24342118)
5. E. Durante-Mangoni, A. Grammatikos, R. Utili, and M.E. Falagas Do we still need the aminoglycosides? Int J Antimicrob Agents 33 2009 201 205
6. S. Carryn, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations Antimicrob Agents Chemother 46 2002 2095 2103 (Pubitemid 34665902)
7. C. Seral, F. Van Bambeke, and P.M. Tulkens Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages Antimicrob Agents Chemother 47 2003 2283 2292 (Pubitemid 36753584)
8. C. Gamazo, S. Prior, M.C. Lecaroz, A.I. Vitas, M.A. Campanero, and G. Perez Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections Expert Opin Drug Deliv 4 2007 677 688 (Pubitemid 350193402)
9. A. Ranjan, N. Pothayee, M.N. Seleem, R.D. Tyler Jr., B. Brenseke, and N. Sriranganathan Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model Int J Nanomed 4 2009 289 297
10. D.E. Owens III, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int J Pharm 307 2006 93 102 (Pubitemid 41773257)
11. S. Ravi, K.K. Peh, Y. Darwis, B.K. Murthy, T.R. Singh, and C. Mallikarjun Development and characterization of polymeric microspheres for controlled release protein loaded drug delivery system Indian J Pharm Sci 70 2008 303 309
12. J.M. Anderson, and M.S. Shive Biodegradation and biocompatibility of PLA and PLGA microspheres Adv Drug Deliv Rev 28 1997 5 24 (Pubitemid 27497671)
13. C. Lecaroz, C. Gamazo, M.J. Renedo, and M.J. Blanco-Prieto Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin J Microencapsul 23 2006 782 792 (Pubitemid 44811441)
14. M.C. Lecaroz, M.J. Blanco-Prieto, M.A. Campanero, H. Salman, and C. Gamazo Poly(d,l-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice Antimicrob Agents Chemother 51 2007 1185 1190 (Pubitemid 46586792)
15. C. Lecaroz, M.J. Blanco-Prieto, M.A. Burrell, and C. Gamazo Intracellular killing of Brucella melitensis in human macrophages with microsphere- encapsulated gentamicin J Antimicrob Chemother 58 2006 549 556 (Pubitemid 44288118)
16. R. Falk, T.W. Randolph, J.D. Meyer, R.M. Kelly, and M.C. Manning Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent J Control Release 44 1997 77 85 (Pubitemid 27051336)
17. Elizondo E, Sala S, Imbuluzqueta E, González D, Blanco-Prieto MJ, Gamazo C, et al. High loading of gentamicin in bioadhesive PVM/MA nanostructured microparticles using compressed carbon-dioxide. Pharm Res 2010. doi: 10.1007/s11095-010-0248-x.
18. D.J. Dixon, K.P. Johnston, and R.A. Bodmeier Polymeric materials formed by precipitation with a compressed fluid antisolvent ALChE J 39 1993 127 139 (Pubitemid 266684)
19. M. Gimeno, N. Ventosa, Y. Boumghar, J. Fournier, I. Boucher, and J. Veciana Micronization of the chitosan derivatives d-glucosamine hydrochloride and d-glucosamine sulphate salts by dense gas anti-solvent precipitation techniques J Supercrit Fluids 38 2006 94 102 (Pubitemid 44093201)
20. S.K. Sahoo, J. Panyam, S. Prabha, and V. Labhasetwar Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake J Control Release 82 2002 105 114 (Pubitemid 34775052)
21. J.R. Benson, and P.E. Hare O-phthalaldehyde: fluorogenic detection of primary amines in the picomole range. Comparison with fluorescamine and ninhydrin Proc Natl Acad Sci USA 72 1975 619 622
22. A. Fahr, and X. Liu Drug delivery strategies for poorly water-soluble drugs Expert Opin Drug Deliv 4 2007 403 416 (Pubitemid 47249138)
23. F. Ahsan, I.P. Rivas, M.A. Khan, and A.I. Torres Suarez Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages J Control Release 79 2002 29 40 (Pubitemid 34164159)
24. Y. Tabata, and Y. Ikada Macrophage phagocytosis of biodegradable microspheres composed of l-lactic acid/glycolic acid homo- and copolymers J Biomed Mater Res 22 1988 837 858
25. A.M. Torche, P. Le Corre, E. Albina, A. Jestin, and R. Le Verge PLGA microspheres phagocytosis by pig alveolar macrophages: influence of poly(vinyl alcohol) concentration, nature of loaded-protein and copolymer nature J Drug Target 7 2000 343 354 (Pubitemid 30137957)
26. H.Y. Nam, S.M. Kwon, H. Chung, S.Y. Lee, S.H. Kwon, and H. Jeon Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles J Control Release 135 2009 259 267
27. S. Prior, B. Gander, N. Blarer, H.P. Merkle, M.L. Subira, and J.M. Irache In vitro phagocytosis and monocyte-macrophage activation with poly(lactide) and poly(lactide-co-glycolide) microspheres Eur J Pharm Sci 15 2002 197 207 (Pubitemid 34155382)
28. H. Saito, H. Tomioka, T. Watanabe, and K. Sato Mechanisms of phagocytosis of Mycobacterium leprae and other mycobacteria by human oligodendroglial cells Infect Immun 51 1986 163 167 (Pubitemid 16200012)
29. Y.I. Basovskiy, M.M. Shkarupeta, S.A. Levitskiy, E.S. Kostryukova, V.N. Lazarev, and V.M. Govorun Hydrophobic domains determine localization of IncC and IncG full-length proteins of C. trachomatis during their expression in cultured HeLa cells Bull Exp Biol Med 145 2008 425 429
30. H. Su, N.G. Watkins, Y.X. Zhang, and H.D. Caldwell Chlamydia trachomatis-host cell interactions: role of the chlamydial major outer membrane protein as an adhesin Infect Immun 58 1990 1017 1025 (Pubitemid 20117034)
31. P.G. Cardoso, G.C. Macedo, V. Azevedo, and S.C. Oliveira Brucella spp. noncanonical LPS: structure, biosynthesis, and interaction with host immune system Microb Cell Fact 5 2006 13 22
32. P.D. Scholes, A.G. Coombes, L. Illum, S.S. Davis, J.F. Watts, and C. Ustariz Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS J Control Release 59 1999 261 278 (Pubitemid 29238171)
33. K.M. Shakesheff, C. Evora, I.I. Soriano, and R. Langer The adsorption of poly(vinyl alcohol) to biodegradable microparticles studied by X-ray photoelectron spectroscopy (XPS) J Colloid Interface Sci 185 1997 538 547 (Pubitemid 27466804)
34. O.Y. Mindyyuk, M.R. Stetzer, P.A. Heiney, J.C. Nelson, and J.S. Moore High resolution X-ray diffraction study of a tubular liquid crystal Adv Mater 10 1998 1363 1366 (Pubitemid 128549410)
35. G. Dalwadi, and B. Sunderland An ion pairing approach to increase the loading of hydrophilic and lipophilic drugs into PEGylated PLGA nanoparticles Eur J Pharm Biopharm 71 2009 231 242
36. L. Yang, F. Cui, K. Shi, D. Cun, and R. Wang Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique Drug Dev Ind Pharm 2009 1 9
37. J.D. Meyer, and M.C. Manning Hydrophobic ion pairing: altering the solubility properties of biomolecules Pharm Res 15 1998 188 193 (Pubitemid 28144228)
38. C. Lecaroz, C. Gamazo, and M.J. Blanco-Prieto Nanocarriers with gentamicin to treat intracellular pathogens J Nanosci Nanotechnol 6 2006 3296 3302 (Pubitemid 44580014)
39. S.H. Choi, and T.G. Park Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres Int J Pharm 203 2000 193 202 (Pubitemid 30627639)
40. L. Lu, C.A. Garcia, and A.G. Mikos In vitro degradation of thin poly(dl-lactic-co-glycolic acid) films J Biomed Mater Res 46 1999 236 244
41. L. Mu, and S.S. Feng PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio Pharm Res 20 2003 1864 1872 (Pubitemid 37449463)