Recent advances in the detection of neonatal candidiasis

Current Fungal Infection Reports

Volumn 4, Issue 1, 2010, Pages 17-22

  Downey, Laura Corbin ^a   Smith, P Brian ^a   Benjamin Jr , Daniel K ^a   Cohen Wolkowiez, Michael ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Candida; Diagnosis; Neonate

Indexed keywords

DNA; FUNGUS ANTIGEN;

BLOOD CULTURE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CANDIDEMIA; CANDIDIASIS; DIAGNOSTIC TEST; DNA SEQUENCE; FOLLOW UP; GENE AMPLIFICATION; HUMAN; IMMUNOCOMPROMISED PATIENT; INVASIVE CANDIDIASIS; NEONATAL CANDIDIASIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REVIEW; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY;

EID: 79952187435     PISSN: 19363761     EISSN: 1936377X     Source Type: Journal    
DOI: 10.1007/s12281-010-0002-1     Document Type: Review

References (37)

1. Stoll BJ, Hansen N, Fanaroff AA, et al.: Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002, 110:285-291. (Pubitemid 34833012)
2. Benjamin DK Jr, Stoll BJ, Fanaroff AA, et al.: Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006, 117:84-92. (Pubitemid 46050523)
3. Cotten CM, McDonald S, Stoll B, et al.: The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 2006, 118:717-722. (Pubitemid 46085430)
4. Saiman L, Ludington E, Pfaller M, et al.: Risk factors for candidemia in neonatal intensive care unit patients. The National Epidemiology of Mycosis Survey study group. Pediatr Infect Dis J 2000, 19:319-324. (Pubitemid 30213071)
5. Feja KN, Wu F, Roberts K, et al.: Risk factors for candidemia in critically ill infants: a matched case-control study. J Pediatr 2005, 147:156-161. (Pubitemid 41207826)
6. Stoll BJ, Gordon T, Korones SB, et al.: Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 1996, 129:63-71. (Pubitemid 26277248)
7. Benjamin DK, DeLong E, Cotten CM, et al.: Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol 2004, 24:175-180. (Pubitemid 38515157)
8. Stoll BJ, Hansen NI, Adams-Chapman I, et al.: Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004, 292:2357-2365. (Pubitemid 39491920)
9. Friedman S, Richardson SE, Jacobs SE, O'Brien K: Systemic Candida infection in extremely low birth weight infants: short term morbidity and long term neurodevelopmental outcome. Pediatr Infect Dis J 2000, 19:499-504. (Pubitemid 30409474)
10. Mittal M, Dhanireddy R, Higgins RD: Candida sepsis and association with retinopathy of prematurity. Pediatrics 1998, 101:654-657. (Pubitemid 28180151)
11. Kremer I, Naor N, Davidson S, et al.: Systemic candidiasis in babies with retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 1992, 230:592-594.
12. Kaufman D: Strategies for prevention of neonatal invasive candidiasis. Semin Perinatol 2003, 27:414-424.
13. Malloy PJ, Zhao X, Madani ND, Feldman D: Cloning and expression of the gene from Candida albicans that encodes a high-affinity corticosteroid-binding protein. Proc Natl Acad Sci U S A 1993, 90:1902-1906. (Pubitemid 23069965)
14. Botas CM, Kurlat I, Young SM, Sola A: Disseminated candidal infections and intravenous hydrocortisone in preterm infants. Pediatrics 1995, 95:883-887.
15. Pera A, Byun A, Gribar S, et al.: Dexamethasone therapy and Candida sepsis in neonates less than 1250 grams. J Perinatol 2002, 22:204-208. (Pubitemid 34461097)
16. Chapman RL, Faix RG: Persistently positive cultures and outcome in invasive neonatal candidiasis. Pediatr Infect Dis J 2000, 19:822-827.
17. Berenguer J, Buck M, Witebsky F, et al.: Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis. Disseminated versus single-organ infection. Diagn Microbiol Infect Dis 1993, 17:103-109. (Pubitemid 23294544)
18. Fernandez J, Erstad BL, Petty W, Nix DE: Time to positive culture and identification for Candida blood stream infections. Diagn Microbiol Infect Dis 2009, 64:402-407.
19. Shepard JR, Merz WG, Gherna M, et al.: Evaluation of yeast traffic light PNA FISH™ for detection of high prevalence Candida species. Poster presented at the 107th American Society for Microbiology General Meeting. Toronto, Canada; May 21-25, 2007.
20. Makhoul IR, Kassis I, Smolkin T, et al.: Review of 49 neonates with acquired fungal sepsis: further characterization. Pediatrics 2001, 107:61-66. (Pubitemid 32055416)
21. Guida JD, Kunig AM, Leef KH, et al.: Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response? Pediatrics 2003, 111:1411-1415.
22. Manzoni P, Mostert M, Galletto P, et al.: Is thrombocytopenia suggestive of organism- specific response in neonatal sepsis? Pediatr Int 2009, 51:206-210.
23. Lunel FM, Mennink-Kersten MA, Ruegebrink D, et al.: Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy. Diagn Microbiol Infect Dis 2009, 64:408-415.
24. Oliveri S, Trovato L, Betta P, et al.: Experience with the Platelia Candida ELISA for the diagnosis of invasive candidosis in neonatal patients. Clin Microbiol Infect 2008, 14:391-393. This is one of the few recent studies on detection of neonatal candidiasis. While just a preliminary study, it suggests the possibility of mannan detection as a helpful tool in the diagnosis of candidemia in select neonates.
25. Verduyn Lunel FM, Donnelly JP, van der Lee HA, et al.: Circulating Candida-specific anti-mannan antibodies precede invasive candidiasis in patients undergoing myelo- ablative chemotherapy. Clin Microbiol Infect 2009, 15:380-386.
26. Alam FF, Mustafa AS, Khan ZU: Comparative evaluation of (1, 3)-beta-D-glucan, mannan and anti-mannan antibodies, and Candida species-specific snPCR in patients with candidemia. BMC Infect Dis 2007, 7:103.
27. Loeffler J, Hebart H, Cox P, et al.: Nucleic acid sequence-based amplification of Aspergillus RNA in blood samples. J Clin Microbiol 2001, 39:1626-1629. (Pubitemid 32275480)
28. Khlif M, Mary C, Sellami H, et al.: Evaluation of nested and realtime PCR assays in the diagnosis of candidaemia. Clin Microbiol Infect 2009, 15:656-661.
29. Dierkes C, Ehrenstein B, Siebig S, et al.: Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis 2009, 9:126.
30. Lehmann LE, Hunfeld KP, Emrich T, et al.: A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol 2008, 197:313-324.
31. Dunyach C, Bertout S, Phelipeau C, et al.: Detection and identification of Candida spp. in human serum by LightCycler real-time polymerase chain reaction. Diagn Microbiol Infect Dis 2008, 60:263-271. (Pubitemid 351253601)
32. Wellinghausen N, Siegel D, Winter J, Gebert S: Rapid diagnosis of candidaemia by real- time PCR detection of Candida DNA in blood samples. J Med Microbiol 2009, 58:1106-1111.
33. Landry ML, Garner R, Ferguson D: Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens. J Clin Microbiol 2005, 43:3136-3139. (Pubitemid 40981313)
34. Rutjes SA, Italiaander R, van den Berg HH, et al.: Isolation and detection of enterovirus RNA from large-volume water samples by using the NucliSens miniMAG system and real-time nucleic acid sequence-based amplification. Appl Environ Microbiol 2005, 71:3734-3740.
35. Borst A, Leverstein-Van Hall MA, Verhoef J, Fluit AC: Detection of Candida spp. in blood cultures using nucleic acid sequencebased amplification (NASBA). Diagn Microbiol Infect Dis 2001, 39:155-160. (Pubitemid 32406170)
36. Widjojoatmodjo MN, Borst A, Schukkink RA, et al.: Nucleic acid sequence-based amplification (NASBA) detection of medically important Candida species. J Microbiol Methods 1999, 38:81-90. (Pubitemid 29460982)
37. Zhao Y, Park S, Kreiswirth BN, et al.: Rapid real-time nucleic acid sequence-based amplification-molecular beacon platform to detect fungal and bacterial bloodstream infections. J Clin Microbiol 2009, 47:2067-2078. This article uses a known technology in a new way; it holds some promise in becoming a useful tool in the diagnosis of candidemia.