Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion

International Journal of Nanomedicine

Volumn 5, Issue 1, 2010, Pages 567-572

  Zeng, Zhaowu ^a   Zhou, Guanglin ^a   Wang, Xiaoli ^b   Huang, Eric Zhijian ^a   Zhan, Xiaori ^a   Liu, Jun ^a   Wang, Shuling ^a   Wang, Anming ^a   Li, Haifeng ^a   Pei, Xiaolin ^a   Xie, Tian ^a  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b YICHUN UNIVERSITY   (China)

Author keywords

Elemene; Microemulsion; Relative bioavailability

Indexed keywords

ALCOHOL; BETA ELEMENE; COSURFACTANT; GLYCEROL; OIL; POLYSORBATE 80; PROPYLENE GLYCOL; WATER; ELEMENE; POLYSORBATE; SESQUITERPENE; SURFACTANT;

ACIDITY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; MALE; MICROANALYSIS; MICROEMULSION; MICROENCAPSULATION; MICROTECHNOLOGY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SURFACE PROPERTY; SURFACE TENSION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRASOUND; VISCOSITY; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CHEMISTRY; EMULSION; ISOLATION AND PURIFICATION; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; SOLUBILITY; SPRAGUE DAWLEY RAT;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; EMULSIONS; FEMALE; MALE; OILS; PARTICLE SIZE; POLYSORBATES; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; SOLUBILITY; SURFACE-ACTIVE AGENTS; WATER;

EID: 79952118666     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/ijn.s12485     Document Type: Article

References (14)

1. Sun MG, Li SB, Zhou L, et al. Chemical constituents of active pharmaceutical ingredients of elemene. J Shenyang Pharm Univ. 2009;26(8):620-622.
2. Chen X, Wei FX, Qu YH. Development in the study of elemene - the active principle of Rhizoma Curcumae. Hebei Chemical Engineering Industry. 2003;(6):9-13.
3. Yao SJ, Liu BY, Lv LY. Studies of reducing poison and increasing effect of elemene emulsions on immune function of tumor-bearing mice after chemiotherapy. Chin Arch Trad Chin Med. 2006;24(3):456-457.
4. Xu XX, Zhuang ZM. Recent advance of pharmacological effects and clinical application of elemene emulsion. Strait Pharm. 2001;13(2): 7-8.
5. Yang H, Yi H. Advance on pharmaceutical microemulsion in China. Chin J New Drugs. 2006;15(10):764-769.
6. Yin YM, Cui FD, Mu CF, et al. Docetaxel microemulsion for enhanced oral bioavailability: Preparation and in vitro and in vivo evaluation. J Control Release. 2009;140(2):86-94.
7. Zhou Y, Liu W. Advance on pharmaceutical application of microemulsion and self-microemulsion drug delivery system. J Northwest Pharm. 2008;23(1):56-58.
8. Yang R, Su LQ, Huang X. Study advance and application of microemulsion in pharmaceutics. Chin J Hospital Pharm. 2007;27(8):1141-1144.
9. The Ministry of Science and Technology of the People's Republic of China. Beijing: Guideline of laboratory animal care [online]. Accessed Jul 11, 2010. Available from: http://www.most.gov.cn/fggw/zfwj/zfwj2006/200609/t20060930_54389.htm
10. Hathout RM, Woodman TJ, Mansour S, et al. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 2010;40(3):188-196.
11. Zeng ZW, Zhou GL, Zhan XR, et al. Determination of content and entrapment efficiency of elemene liposomes with UPLC method. Chin J Pharm Anal. 2010;30(3):508-510.
12. Zhang XY, Deng YJ, Zhao CJ, et al. Study on pharmacokinetics of PVP coated β-elemene liposome in rats. J Chin Med Mater. 2006; 9(2):157-160.
13. Barone G, Chang CT, Choc MG Jr, et al. The pharmacokinetics of a microemulsion formulation of cyclosporine in primary renal allograft recipients. The Neoral Study Group. Transplantation. 1996;61(6): 875-880.
14. Bali V, Ali M, Ali J. Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids Surf B: Biointerfaces. 2010;76(2):410-420.