Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: A physicochemical and in-vitro evaluation

International Journal of Nanomedicine

Volumn 5, Issue 1, 2010, Pages 621-630

  Sahana, Basudev ^a   Santra, Kousik ^a   Basu, Sumit ^a   Mukherjee, Biswajit ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Biodegradable; Nanoparticles; PLGA; Stability; Tamoxifen citrate

Indexed keywords

NANOPARTICLE; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL; TAMOXIFEN CITRATE; ANTIESTROGEN; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; TAMOXIFEN;

ARTICLE; BIODEGRADABLE IMPLANT; BREAST CANCER; CONTROLLED STUDY; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; IN VITRO STUDY; LIGHT SCATTERING; NANOANALYSIS; NANOEMULSION; NANOFABRICATION; PARTICLE SIZE; PROCESS OPTIMIZATION; SUSTAINED DRUG RELEASE; BREAST TUMOR; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; INFRARED SPECTROSCOPY; NANOMEDICINE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

BREAST NEOPLASMS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POLYGLYCOLIC ACID; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TAMOXIFEN;

EID: 79952117739     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S9962     Document Type: Article

References (24)

1. Orive G, Harnandez RM, Gascon AR, et al. Micro and nano drug delivery systems in cancer therapy. Cancer Ther. 2005;3:131-138.
2. Bilensoy EM, Vural I, Bochot A, et al. Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles; in-vitro characterization and cytotoxicity. J Control Release. 2005;104(3):489-496.
3. Reagan RMO, Jordan C. The evolution of tamoxifen therapy in breast cancer: selective estrogen receptor modulators and down regulators. Lancet Oncol. 2002;3(4):207-214.
4. Pappas SG, Jordan VC. Chemoprevention of breast cancer; current and future prospects. Cancer Metastasis Rev. 2002;21(3-4):311-321.
5. Powles TJ. Anti-estrogenic chemoprevention of breast cancer-the need to progress. Eur J Cancer. 2003;39(5):572-579.
6. Petero-Engl C, Frank W, Danamayr E, et al. Association between endometrial cancer and tamoxifen treatment of breast cancer. Breast Cancer Treat. 1999;54(3):255-260.
7. Cohen I. Endometrial pathologies associated with postmenopausal tamoxifen treatment. Gynecol Oncol. 2004;94(2):256-266.
8. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissues. Adv Drug Deliv Rev. 2003;55(3): 329-347.
9. Birnbaum DT, Brannon-Peppas L. Microparticle drug delivery systems. In: Brown DM. Drug delivery systems in cancer therapy (cancer drug discovery). Totowa, NJ: Humana Press. 2003:117-135.
10. Reddy LH, Vivek K, Bakshi N, et al. Tamoxifen citrate loaded solid lipid nanoparticles: preparation, characterization, in vitro drug release, and pharmacokinetic evaluation. Pharm Dev Technol. 2006;11(2): 167-177.
11. Sarmah JK, Bhattacharjee SK, Maganta R, et al. Preparation of crosslinked guar gum nanospheres containing tamoxifen citrate by single step emulsion in situ polymer crosslinking method. J Inclusion Phenomena Macrocyclic Chem. 2009;65(3-4):329-334.
12. Gerelli Y, Di Bari MT, Deriu A, et al. Structure and organization of phospholipid/polysaccharide nanoparticles. J Phys Condens Matter. 2008;120:104211.
13. Yezhelyev M, Yakoub R, O'Regan R. Inorganic nanoparticles for predictive oncology of breast cancer. Nanomedicine. 2009;4(1):83-103.
14. Bilensoy E, DoA L, Hancal A. Complexation behavior of antiestrogen drug tamoxifen citrate with natural and modified cyclodextrins. J Inclusion Phenomena Macrocyclic Chem. 2007;57(1-4): 651-655.
15. Sehra S, Dhake AS. Formulation and evaluation of sustained release microspheres of poly-lactide-co-glycolide containing tamoxifen citrate. J Microencapsulation. 2005;22(5):521-528.
16. Mainardes RM, Silva LP. Drug delivery systems: past, present and future. Curr Drug Targets. 2004;5(5):449-455.
17. Kumari A, Yadav SK, Yadav SC. Biodegradable, polymeric nanoparticles based drug delivery systems. Colloids Surfaces B: Biointerfaces. 2009;75(1):1-18.
18. Betancourt T, Brown B, Brannon-Peppas L. Doxorubicin-loaded PLGA nanoparticles by nanoprecipitation: preparation, characterization and in vitro evaluation. Nanomedicine. 2007;2(2):219-232.
19. Mittal G, Sahana DK, Bhardwaj V, et al. Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release. 2007;119(1):77-85.
20. Sinha VR, Trehan A. Formulation, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres. Drug Delivery. 2005;12:133-139.
21. Mukherjee B, Santra K, Pattnaik G, et al. Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. Int J Nanomed. 2008;3(4): 487-496.
22. Lemoine D, Preat V. Polymeric nanoparticles as delivery system for influenza virus glycoproteins. J Control Release. 1998;54(1):15-27.
23. Ghosh S, Roy G, Mukherjee B. Dental mold: a novel formulation to treat common dental disorders. AAPS Pharm Sci Tech. 2009;10(2): 692-702.
24. Beckett AH, Stenlake JB. Infrared spectrophotometry. In: Practical pharmaceutical chemistry. Fourth edition, part two. CBS Publishers, New Delhi, India:1997:384-390.