Citicoline preclinical and clinical update 2009-2010

Stroke

Volumn 42, Issue SUPPL. 1, 2011, Pages

  Dávalos, Antoni ^a   Secades, Julio ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Ferrer Grupo   (Spain)

Author keywords

Acute stroke; Brain repair; Citicoline; Neuroprotection

Indexed keywords

ALTEPLASE; CITICOLINE; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT;

BLEEDING; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL PROTECTION; CLINICAL TRIAL; COGNITIVE DEFECT; CONFERENCE PAPER; DRUG DOSE COMPARISON; DRUG INDUCED HEADACHE; DRUG SAFETY; GASTROINTESTINAL SYMPTOM; HUMAN; MESENCHYMAL STEM CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; STROKE; ACUTE DISEASE; ANIMAL; CONVALESCENCE; DRUG EFFECT; DRUG SCREENING; REVIEW;

ACUTE DISEASE; ANIMALS; BRAIN ISCHEMIA; CYTIDINE DIPHOSPHATE CHOLINE; DRUG EVALUATION, PRECLINICAL; HUMANS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; RECOVERY OF FUNCTION; STROKE;

EID: 79952117535     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.605568     Document Type: Conference Paper

References (17)

1. Secades JJ, Lorenzo JL. Citicoline: Pharmacological and clinical review, 2006 Update. Methods Find Exp Clin Pharmacol. 2006;28(Suppl B):1-56. (Pubitemid 44569736)
2. Adibhatla RM, Hatcher JF, Larsen EC. Cytokine biology, lipid metabolism and citicoline in stroke. J Cereb Blood Flow Metab. 2007;27(Suppl 1): B06-B02.
3. Adibhatla RM, Hatcher JF. Role of lipids in brain injury and diseases. Future Lipidol. 2007;2:403-422. (Pubitemid 47250149)
4. Adibhatla RM, Hatcher JF. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2010;12:125-169.
5. Lee HJ, Kang JS, Kim YI. Citicoline protects against cognitive impairment in a rat model of chronic cerebral hypoperfusion. J Clin Neurol. 2009;5:33-38.
6. Giralt D, García-Bonilla L, Campos M, Sosti V, Rosell A, Montaner J. Selecting the optimal dose of citicoline treatment in animal models of focal cerebral ischemia through a meta-analysis. Cerebrovasc Dis. 2010; 29(Suppl 2):165.
7. Guitiérrez M, Rodriguez-Frutos B, Alvarez-Grech J, Exposito-Alcaide M, Vallejo-Cremades M, Merino J, Diez-Tejedor E. Effects of citicoline and mesenchymal stem cells in acute cerebral infarct. Experimental study in rats. Cerebrovasc Dis. 2010;29(Suppl 2):317-318.
8. Pérez de la Ossa N, Sobrino T, Silva Y, Blanco M, Millán M, Gomis M, Agulla J, Araya P, Reverté S, Serena J, Dávalos A. Iron-related brain damage in patients with intracerebral hemorrhage. Stroke. 2010;41: 810-813.
9. De Gregorio-Rocasolano N, Ponce J, Guirao V, Pérez de la Ossa N, Dávalos A, Gasull T. Iron overload increases early death of neurons during hypoxia and lowers the opportunity to save neurons after reperfusion. Cerebrovasc Dis. 2009;27(suppl 6):114.
10. Saver JL. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Rev Neurol Dis. 2008;5:167-177.
11. Cho HJ, Kim YJ. Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases. Methods Find Exp Clin Pharmacol. 2009;31:171-176.
12. Sobrino T, Hurtado O, Moro MA, Rodríguez-Yáñez M, Castellanos M, Brea D, Moldes O, Blanco M, Arenillas JF, Leira R, Dávalos A, Lizasoain I, Castillo J. The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome. Stroke. 2007;38:2759-2764. (Pubitemid 47494015)
13. Sobrino T, Rodríguez-González R, Blanco M, Brea D, Pérez-Mato M, Rodríguez-Yáñez M, Leira R, Castillo J. CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. Neurol Res. 2010; in press.
14. Ortega G, Jacas C, Quintana M, Ribó M, Santamarina E, Maisterra O, Molina C, Montaner J, Roman G, Alvarez-Sabín J. Citicoline treatment prevents neurocognitive decline after a first ischemic stroke. Cerebrovasc Dis. 2010;29(Suppl 2):268.
15. Zafonte R, Friedewald WT, Lee SM, Levin B, Diaz-Arrastia R, Ansel B, Eisenberg H, Timmons SD, Temkin N, Novack T, Ricker J, Merchant R, Jallo J. The citicoline brain injury treatment (COBRIT) trial: design and methods. J Neurotrauma. 2009;26:2207-2216.
16. Dávalos A. Protocol 06PRT/3005: ICTUS study: International Citicoline Trial on acUte Stroke (NCT00331890) oral citicoline in acute ischemic stroke. Lancet Protocol Reviews 2007. Available at: http://www.thelancet.com/ journals/lancet/misc/protocol/protocolreviews. Accessed April 10, 2008.
17. Bolland K, Whitehead J, Cobo E, Secades JJ. Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline. Pharm Stat. 2009;8:136-149.