Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 10, 2010, Pages 1935-1942

  Thews, Oliver ^a   Dillenburg, Wolfgang ^a   Fellner, Marco ^b   Buchholz, Hans Georg ^a   Bausbacher, Nicole ^a   Schreckenberger, Mathias ^a   Rösch, Frank ^b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

68Ga; 68Ga MFL6.MZ; Acidosis; ERK1 2; P glycoprotein; P38; Transport activity. PET

Indexed keywords

GALLIUM 68; GLYCOPROTEIN P; LACTIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SCHIFF BASE; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; DIAGNOSTIC AGENT; DRUG; GALLIUM; NITRILE; PROTEIN KINASE INHIBITOR; TRACER;

ACIDITY; ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; HYPOXIA; IN VIVO STUDY; INHIBITION KINETICS; INSPIRATORY CAPACITY; MALE; NONHUMAN; PH; POSITRON EMISSION TOMOGRAPHY; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; EXTRACELLULAR SPACE; METABOLISM; SCINTISCANNING; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ACIDOSIS; ANIMALS; BIOLOGICAL TRANSPORT; BUTADIENES; CELL LINE, TUMOR; EXTRACELLULAR SPACE; GALLIUM RADIOISOTOPES; HYDROGEN-ION CONCENTRATION; MALE; MAP KINASE SIGNALING SYSTEM; NITRILES; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN KINASE INHIBITORS; RADIOACTIVE TRACERS; RATS;

EID: 79952108774     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-010-1504-3     Document Type: Article

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