Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness

NeuroToxicology

Volumn 32, Issue 2, 2011, Pages 242-246

  Liu, Peiying ^a   Aslan, Sina ^a   Li, Xiufeng ^b   Buhner, David M ^a,b   Spence, Jeffrey S ^a,b   Briggs, Richard W ^b   Haley, Robert W ^a,b   Lu, Hanzhang ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arterial spin labeling MRI; Brain diseases; Cerebral blood flow; Gulf War Illness; Phase contrast MRI; Physostigmine

Indexed keywords

BIOLOGICAL MARKER; CHOLINERGIC RECEPTOR STIMULATING AGENT; GLYCOPYRRONIUM BROMIDE; PHYSOSTIGMINE;

ADULT; AGE; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; COGNITIVE DEFECT; DRUG INFUSION; EDUCATIONAL STATUS; GENDER; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MALE; NERVOUS SYSTEM INJURY; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSIAN GULF SYNDROME; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPIN LABELING; UNSPECIFIED SIDE EFFECT; VETERAN;

ADULT; AGED; CEREBROVASCULAR CIRCULATION; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; GULF WAR; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PERSIAN GULF SYNDROME; PHYSOSTIGMINE; REGIONAL BLOOD FLOW; VETERANS;

EID: 79952102887     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2010.12.004     Document Type: Article

References (16)

1. Binns JH, Golomb BA, Graves JC, Haley RW, Knox ML, Meggs WJ, et al. Scientific progress in understanding gulf war veterans' illnesses: report and recommendations. Illnesses RACoGWV. Washington. Available at ; 2004. http://www1.va.gov/rac-gwvi/docs/ReportandRecommendations_2004.pdf.
2. Fukuda K., Nisenbaum R., Stewart G., Thompson W.W., Robin L., Washko R.M., et al. Chronic multisymptom illness affecting air force veterans of the gulf war. JAMA 1998, 280:981-988.
3. Golomb B.A. Acetylcholinesterase inhibitors and gulf war illnesses. Proc Natl Acad Sci U S A 2008, 105:4295-4300.
4. Haley R.W., Kurt T.L., Hom J. Is there a gulf war syndrome? Searching for syndromes by factor analysis of symptoms. JAMA 1997, 277:215-222.
5. Haley R.W., Luk G.D., Petty F. Use of structural equation modeling to test the construct validity of a case definition of gulf war syndrome: invariance over developmental and validation samples, service branches and publicity. Psychiatry Res 2001, 102:175-200.
6. Haley R.W., Spence J.S., Carmack P.S., Gunst R.F., Schucany W.R., Petty F., et al. Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 gulf war. Psychiatry Res 2009, 171:207-220.
7. Heaton K.J., Palumbo C.L., Proctor S.P., Killiany R.J., Yurgelun-Todd D.A., White R.F. Quantitative magnetic resonance brain imaging in US army veterans of the 1991 gulf war potentially exposed to sarin and cyclosarin. Neurotoxicology 2007, 28:761-769.
8. Henderson R.F., Barr E.B., Blackwell W.B., Clark C.R., Conn C.A., Kalra R., et al. Response of rats to low levels of sarin. Toxicol Appl Pharmacol 2002, 184:67-76.
9. Henderson R.F., Barr E.B., Blackwell W.B., Clark C.R., Conn C.A., Kalra R., et al. Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of gulf war illness. Toxicol Ind Health 2001, 17:294-297.
10. Kang H.K., Mahan C.M., Lee K.Y., Murphy F.M., Simmens S.J., Young H.A., et al. Evidence for a deployment-related gulf war syndrome by factor analysis. Arch Environ Health 2002, 57:61-68.
11. Kassa J., Koupilova M., Herink J., Vachek J. The long-term influence of low-level sarin exposure on behavioral and neurophysiological functions in rats. Acta Med (Hradec Kralove) 2001, 44:21-27.
12. Menon P.M., Nasrallah H.A., Reeves R.R., Ali J.A. Hippocampal dysfunction in gulf war syndrome. A proton MR spectroscopy study. Brain Res 2004, 1009:189-194.
13. Meyerhoff D.J., Lindgren J., Hardin D., Griffis J.M., Weiner M.W. Metabolic abnormalities in the brain of subjects with gulf war illness. Proc Int Soc Magn Reson Med 2001.
14. Morris M., Key M.P., Farah V. Sarin produces delayed cardiac and central autonomic changes. Exp Neurol 2007, 203:110-115.
15. Proctor S.P., Heaton K.J., Heeren T., White R.F. Effects of sarin and cyclosarin exposure during the 1991 gulf war on neurobehavioral functioning in US army veterans. Neurotoxicology 2006, 27:931-939.
16. Roland P.S., Haley R.W., Yellin W., Owens K., Shoup A.G. Vestibular dysfunction in gulf war syndrome. Otolaryngol Head Neck Surg 2000, 122:319-329.