Rab GTPases act in sequential steps to regulate phagolysosome formation

Small GTPases

Volumn 1, Issue 3, 2010, Pages 170-173

  Guo, Pengfei ^a   Wang, Xiaochen ^a  

^a NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

Apoptotic cell degradation; C. elegans; Phagolysosome; Phagosome maturation; Rab GTPase; RAB 14

Indexed keywords

RAB PROTEIN; RAB14 PROTEIN; RAB2 PROTEIN; RAB7 PROTEIN; SNARE PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL FUSION; CELL MATURATION; INTERNALIZATION; LYSOSOME; MEMBRANE TRANSPORT; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; PHAGOCYTOSIS; PHAGOLYSOSOME; PHAGOSOME; PROTEIN FUNCTION;

CAENORHABDITIS ELEGANS;

EID: 79952092390     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.1.3.14511     Document Type: Article

References (24)

1. Kinchen JM, Ravichandran KS. Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol 2008; 9:781-95.
2. Zhou Z, Yu X. Phagosome maturation during the removal of apoptotic cells: receptors lead the way. Trends Cell Biol 2008; 18:474-85.
3. Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M. Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature 2008; 453:241-5.
4. Yu X, Lu N, Zhou Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol 2008; 6:61.
5. Mangahas PM, Yu X, Miller KG, Zhou Z. The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. J Cell Biol 2008; 180:357-73.
6. Lu Q, Zhang Y, Hu T, Guo P, Li W, Wang X. C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development 2008; 135:1069-80.
7. Kinchen JM, Doukoumetzidis K, Almendinger J, Stergiou L, Tosello-Trampont A, Sifri CD, et al. A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol 2008; 10:556-66.
8. Guo P, Hu T, Zhang J, Jiang S, Wang X. Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. Proc Natl Acad Sci USA 2010; 107:18016-21.
9. Li W, Zou W, Zhao D, Yan J, Zhu Z, Lu J, Wang X. C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development 2009; 136:2445-55.
10. Huynh KK, Grinstein S. Regulation of vacuolar pH and its modulation by some microbial species. Microbiol Mol Biol Rev 2007; 71:452-62.
11. Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S. Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol Cell Biol 2003; 23:6494-506.
12. +-ATPase in vesicular trafficking: targeting, regulation and function. Curr Opin Cell Biol 2008; 20:415-26.
13. + ATPase: molecular structure and function, physiological roles and regulation. J Exp Biol 2006; 209:577-89.
14. Tisdale EJ, Balch WE. Rab2 is essential for the maturation of pre-Golgi intermediates. J Biol Chem 1996; 271:29372-9.
15. Tisdale EJ. A Rab2 Mutant with Impaired GTPase Activity Stimulates Vesicle Formation from Pre- Golgi Intermediates. Molecular Biology of the Cell 1999; 10:1837-49.
16. Junutula JR, De Maziere AM, Peden AA, Ervin KE, Advani RJ, van Dijk SM, et al. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell 2004; 15:2218-29.
17. Chun DK, McEwen JM, Burbea M, Kaplan JM. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Mol Biol Cell 2008; 19:2682-95.
18. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 2009; 10:513-25.
19. Cai H, Reinisch K, Ferro-Novick S. Coats, tethers, Rabs and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell 2007; 12:671-82.
20. Xiao H, Chen D, Fang Z, Xu J, Sun X, Song S, et al. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Mol Biol Cell 2009; 20:21-32.
21. Steinberg BE, Huynh KK, Grinstein S. Phagosomal acidification: measurement, manipulation and functional consequences. Biochem Soc Trans 2007; 35:1083-7.
22. Markgraf DF, Peplowska K, Ungermann C. Rab cascades and tethering factors in the endomembrane system. FEBS Lett 2007; 581:2125-30.
23. Kinchen JM, Ravichandran KS. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Nature 2010; 464:778-82.
24. Roberts EA, Chua J, Kyei GB, Deretic V. Higher order Rab programming in phagolysosome biogenesis. J Cell Biol 2006; 174:923-9.