Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma: A single-center, randomized, double-blind, controlled study

Current Therapeutic Research - Clinical and Experimental

Volumn 71, Issue 6, 2010, Pages 345-359

  Viyoch, Jarupa ^a   Tengamnuay, Isaree ^b   Phetdee, Khemjira ^a   Tuntijarukorn, Punpimol ^a   Waranuch, Neti ^a  

^a NARESUAN UNIVERSITY   (Thailand)

^b Pazana Laboratory Asia Co Ltd   (Thailand)

Author keywords

Melasma; Thai adults; Trans 4 (aminomethyl) cyclohexanecarboxylic acid potassium azeloyl diglycinate niacinamide

Indexed keywords

MELANIN; NICOTINAMIDE PLUS POTASSIUM AZELOYL DIGLYCINATE PLUS TRANEXAMIC ACID; SKIN PROTECTIVE AGENT; SUNSCREEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BURNING SENSATION; CHLOASMA; CLINICAL ARTICLE; CLINICAL ASSESSMENT; DERMATITIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; EDEMA; EMULSION; ERYTHEMA; FACIAL DERMATITIS; FACIAL MELASMA; FEMALE; HUMAN; HYPERPIGMENTATION; MALE; MOISTURE; PH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM; SKIN PROTECTION; SKIN REDNESS; SUN EXPOSURE; THERAPY EFFECT; TREATMENT DURATION;

EID: 79952090470     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(10)80001-3     Document Type: Article

References (28)

1. Pandya AG, Guevara IL Disorders of hyperpigmentation. Dermatol Clin. 2000, 18:91-98.
2. Pandya AG, Guevara IL Disorders of hyperpigmentation. Dermatol Clin. 2000, 18:ix.
3. Lawrence N, Cox SE, Brody HJ Treatment of melasma with Jessner's solution versus glycolic acid: A comparison of clinical efficacy and evaluation of the predictive ability of Wood's light examination. J Am Acad Dermatol. 1997, 36:589-593.
4. Grimes PE Melasma. Etiologic and therapeutic considerations. Arch Dermatol. 1995, 131:1453-1457.
5. Sanchez NP, Pathak MA, Sato S, et al. Melasma: A clinical, light microscopic, ultrastructural, and immunofluorescence study. J Am Acad Dermatol. 1981, 4:698-710.
6. Pichardo R, Vallejos Q, Feldman SR, et al. The prevalence of melasma and its association with quality of life among adult male migrant Latino workers. Int J Dermatol. 2009, 48:22-26.
7. Balkrishnan R, Mcmichael AJ, Camacho FT, et al. Development and validation of a health-related quality of life instrument for women with melasma. Br J Dermatol. 2003, 149:572-577.
8. Gupta AK, Gover MD, Nouri K, Taylor S The treatment of melasma: A review of clinical trials. J Am Acad Dermatol. 2006, 55:1048-1065.
9. Rendon M, Berneburg M, Arellana I, et al. Treatment of melasma. J Am Acad Dermatol. 2006, 54:S272-S281.
10. Cestari T, Adjadj L, Hux M, et al. Cost-effectiveness of a fixed combination of hydroquinone/ tretinoin/fluocinolone cream compared with hydroquinone alone in the treatment of melasma. J Drugs Dermatol. 2007, 6:153-160.
11. Maeda K, Naganuma M Topical trans-4-aminomethylcyclohexanecarboxylic acid prevents ultraviolet radiation-induced pigmentation. J Photochem Photobiol. 1998, 47:136-141.
12. Solano F, Briganti S, Picardo M, Ghanem G Hypopigmenting agents: An updated review on biological, chemical and clinical aspects. Pigment Cell Res. 2006, 19:550-571.
13. Maramaldi G, Esposito MA Potassium azeloyl diglycinate: A multifunctional skin lightener. Cosmet Toilet. 2002, 117:43-50.
14. Rigano L, Cucchiara M Azeloyl diglycinate: A new active in skin disequilibrium. J Appl Cosmetol. 2003, 21:177-188.
15. Azelaic acid derivative whitening efficacy studied January 2007, Personal Care, Accessed May 18, 2010. http://www.personalcaremagazine.com/Story.aspx?Story=1903.
16. Hakozaki T, Minwalla L, Zhuang J, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002, 147:20-31.
17. Yoshimura K, Harii K, Aoyama T, et al. A new bleaching protocol for hyperpigmented skin lesions with a high concentration of all-trans retinoic acid aqueous gel. Aesthetic Plast Surg. 1999, 23:285-291.
18. Yoshimura K, Harii K, Aoyama T, Iga T Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals. Plast Reconstr Surg. 2000, 105:1097-1108. discussion.
19. Yoshimura K, Harii K, Aoyama T, Iga T Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals. Plast Reconstr Surg. 2000, 105:1109-1110.
20. Griffiths CE, Finkel LJ, Ditre CM, et al. Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled clinical trial. Br J Dermatol. 1993, 129:415-421.
21. Sharquie KE, Al-Tikreety MM, Al-Mashhadani SA Lactic acid chemical peels as a new therapeutic modality in melasma in comparison to Jessner's solution chemical peels. Dermatol Surg. 2006, 32:1429-1436.
22. Zhai H, Hannon W, Hahn GS, et al. Strontium nitrate suppresses chemically-induced sensory irritation in humans. Contact Dermatitis. 2000, 42:98-100.
23. Frosch PJ, Kligman AM The soap chamber test. A new method for assessing the irritancy of soaps. J Am Acad Dermatol. 1979, 1:35-41.
24. Maenthaisong R, Viyoch J, Chaiyakunapruk N, Warnnissorn P Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in humans. J Cosmet Dermatol. 2007, 6:178-182.
25. Dutkiewicz R, Albert DM, Levin LA Effects of latanoprost on tyrosinase activity and mitotic index of cultured melanoma lines. Exp Eye Res. 2000, 70:563-569.
26. Lowe NJ, Rizk D, Grimes P, et al. Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. Clin Ther. 1998, 20:945-959.
27. Eberlein-König B, Schäfer T, Huss-Marp J, et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm Venereol. 2000, 80:188-191.
28. Baranda L, González-Amaro R, Torres-Alvarez B, et al. Correlation between pH and irritant effect of cleansers marketed for dry skin. Int J Dermatol. 2002, 41:494-499.