Synthesis of novel imidazo[1,5-a]pyridine derivates

Revue Roumaine de Chimie

Volumn 55, Issue 10, 2010, Pages 689-695

  Mihorianu, Monica ^a   Mangalagiu, Ionel ^a   Jones, Peter G ^b   Daniliuc, Constantin Gabriel ^b   Franz, M Heiko ^b   Neda, Ion ^b  

^a ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79952090170     PISSN: 00353930     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

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33. To a mixture of triphosgene in 100 ml of chlorbenzene cooled down to 00C was added dropwise the amine (1) dissolved in 150 mL chlorobenzene. When addition was finished the reaction mixture was allowed to warm up to room temperature. Reaction was monitored by disappearance of the amine (1) by TLC analysis. When reaction was finished the pyridine was added and the reaction mixture was filtered and excess of solvent was distilled off at a pressure of 1 mbar. The residue was concentrated under reduced pressure and purified on silica gel (ethyl acetate : hexane). The product (6) was obtained in 45% yield.
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