Erythropoietin and mild traumatic brain injury: Neuroprotective potential and dangerous side-effects

Journal of Biological Sciences

Volumn 10, Issue 8, 2010, Pages 739-746

  Evans, P ^a   Persinger, M A ^a  

^a LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Conditioned fear; Erythropoietin; Neuroprotection; TBI

Indexed keywords

RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CELL DAMAGE; CELL SURVIVAL; CONTROLLED STUDY; FEAR; FEMALE; HEMATOCRIT; HISTOPATHOLOGY; LONG TERM CARE; MAZE TEST; NERVE CELL; NEUROPROTECTION; NONHUMAN; RAT; REINFORCEMENT; SEIZURE; SPLEEN HEMATOMA; TRAUMATIC BRAIN INJURY;

ANIMALIA; RATTUS NORVEGICUS;

EID: 79952084210     PISSN: 17273048     EISSN: 18125719     Source Type: Journal    
DOI: 10.3923/jbs.2010.739.746     Document Type: Article

References (54)

1. Annegers, J.F., J.D. Grabow, R.V. Groover, Jr. E.R. Laws, L.R. Elveback and L.T. Kurland, 1980. Seizures after head trauma: A population study. Neurology, 30: 683-689.
2. Annegers, J.F., W.A. Hauser, S.P. Coan and W. A. Rocca, 1998. A population-based study of seizures after traumatic brain injuries. N. Engl. J. Med., 338: 20-24.
3. Bazarian, J.J., J. McClung, M.N. Shah, Y.T. Cheng, W. Flesher and J. Kraus, 2005. Mild traumatic brain injury in the United States, 1998-2000. Brain Inj., 19: 85-91.
4. Bento, R.M.D.A., L.M.P. Damasceno and F.R.D. Aquino Neto, 2003. Recombinant human eiythropoietin in sports: A review. Rev. Brasileira Med. Esporte, 9: 181-190.
5. Berglund, B. and B. Ekblom, 1991. Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men. J. Int. Med., 229: 125-130.
6. Bernaudin, M., H.H. Marti, S. Roussel, D. Divoux, A. Nouvelot, E.T. MacKenzie and E. Petit 1999. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J. Cereb. Blood Flow Metab., 19: 643-651.
7. Bohnen, N. and J. Jolles, 1992. Neurobehavioral aspects of postconcussive symptoms after mild head injury. J. Nerv. Ment. Dis., 180: 683-692.
8. Boran, M., C. Kucukaksu, M. Balk and S. Cetin, 1998. Red cell lipid peroxidation and antioxidant system in haemodialysed patients: Influence of recombinant human erythropoietin (r-HuEPO) treatment. Int. Urol. Nephrol., 30: 507-512.
9. Bouton, M.E. and R.C. Bolles, 1979. Role of conditioned contextual stimuli in reinstatement of extinguished fear. J. Exp. Psychol. Anim. Behav. Process., 5: 368-378.
10. Brines, M.L., P. Ghezzi, S. Keenan, D. Agnello and N.C. de Lanerolle et al., 2000. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. USA., 97: 10526-10531.
11. Cavdar, C., T. Camsari, I. Semin, S. Gonenc and O. Acikgoz, 1997. Lipid peroxidation and antioxidant activity in chronic haemodialysis patients treated with recombinant human erythropoietin. Scand. J. Urol. Nephrol., 31: 371-375.
12. Coonley-Hoganson, R., N. Sachs, B.T. Desai and S. Whitman, 1984. Sequelae associated with head injuries in patients who were not hospitalized: A follow-up survey. Neurosurgery, 14: 315-317.
13. Cooper, G.W. and B. Cooper, 1977. Relationships between blood platelet and erythrocyte formation. Life Sci., 20: 1571-1579.
14. Digicaylioglu, M. and S. A. Lipton, 2001. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signaling cascades. Nature, 412: 641-647.
15. Du, C., R. Hu, C.A. Csernansky, C. Y. Hsu and D. W. Choi, 1996. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis. J. Cereb. Blood Flow Metab., 16: 195-201.
16. Egrie, J.C., T.W. Strickland, J. Lane, K. Aoki and A.M. Cohen et al., 1986. Characterization and biological effects of recombinant human erythropoietin. Immunobiology, 172: 213-224.
17. Ekblom, B., A.N. Goldbarg and B. Gullbring, 1972. Response to exercise after blood loss and reinfusion. J. Applied Physiol., 33: 175-180.
18. Fanselow, M.S. and R.C. Bolles, 1979. Naloxone and shock-elicited freezing in the rat. J. Comp. Physiol. Psychol., 93: 736-744.
19. Fisher, J.W., 1997. Erythropoietin: Physiologic and pharmacologic aspects. Proc. Soc. Exp. Biol. Med., 216: 358-369.
20. Gareau, R., M. Audran, R.D. Baynes, C.H. Flowers, A. Duvallet, L. Senecal and G.R. Brisson, 1996. Eiythropoietin abuse in athletes. Nature, 380: 113-113.
21. Graber, S.E. and S.B. Krantz, 1978. Eiythropoietin and the control of red cell production. Annu. Rev. Med., 29: 51-66.
22. Jelkmann, W., 2000. Use of recombinant human erythropoietin as an antianemic and performance enhancing drug. Curr. Pharm. Biotechnol., 1: 11-31.
23. Kato, M., K. Miura, H. Kamiyama, A. Okazaki, K. Kumaki, Y. Kato and Y. Sugiyama, 1998. Pharmacokinetics of erythropoietin in genetically anemic mice. Drug Metab. Dispos., 26: 126-131.
24. Kaufman, J.S., D.J. Reda, C.L. Fye, D.S. Goldfarb and W.G. Henderson et al, 1998. Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis. N. Engl. J. Med., 339: 578-583.
25. Kumon, Y., S.C. Kim, P. Tompkins, A. Stevens, S. Sakaki and C.M. Loftus, 2000. Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J. Neurosurg., 92: 848-852.
26. Kumral, A., N. Uysal, K. Tugyan, A. Sonmez and O. Yilmaz et al., 2004. Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav. Brain Res., 153: 77-86.
27. Lado, W.E. and M.A. Persinger, 2003. Mechanical impacts to the skulls of rats produce specific deficits in maze performance and weight loss: Evidence of apoptosis of cortical neurons and implications for clinical neuropsychology. Percep. Motor Skills, 97: 1115-1127.
28. Lei, B., J.E. Cottrell and I.S. Kass, 2001. Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia. Anesthesiology, 95: 445-451.
29. Lu, D., A. Mahmood, C. Qu, A. Goussev, T. Schallert and M. Chopp, 2005. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J. Neurotrauma, 22: 1011-1017.
30. Lyeth, B.G., M. Ray, R.J. Hamm, J. Schnabel and J.J. Saady et al., 1992. Postinjury scopolamine administration in experimental traumatic brain injury. Brain Res., 569: 281-286.
31. Magnani, M., D. Corsi, M. Bianchi, M. Paiardini, L. Galluzzi, A. Parisi and F. Pigozzi, 1999. Monitoring erythropoietin abuse in athletes. Br. J. Haematol., 106: 260-261.
32. Marti, H.H., R.H. Wenger, L.A. Rivas, U. Straumann and M. Digicaylioglu et al., 1996. Erythropoietin gene expression in human, monkey and murine brain. Eur. J. Neurosci., 8: 666-676.
33. Marti, H.H., 2004. Erythropoietin and the hypoxic brain. J. Exp. Biol., 207: 3233-3242.
34. Matchett, G., J. Hahn, A. Obenaus and J. Zhang, 2006. Surgically induced brain injury in rats: the effect of erythropoietin. J. Neurosci. Methods, 158: 234-241.
35. Miller, J.D., 1993. Head injury. J. Neurol. Neurosurg. Psychiatry, 56: 440-447.
36. Moon, J.W., S.A. Chae and D.K. Lee, 1999. Clinical study of post-traumatic seizure in childhood and adolescence. J. Korean Pediatr. Soc., 42: 227-232.
37. Morishita, E., S. Masuda, M. Nagao, Y. Yasuda and R. Sasaki, 1997. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience, 76: 105-116.
38. Murphy, S.T. and P.S. Parfrey, 1999. Erythropoietin therapy in chronic uremia: The impact of normalization of hematocrit. Curr. Opin. Nephrol. Hypertens, 8: 573-578.
39. Ribatti, D., M. Presta, A. Vacca, R. Ria and R. Giuliani et al., 1999. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood, 93: 2627-2636.
40. Rutland-Brown, W., J.A. Langlois, K.E. Thomas and Y.L. Xi, 2006. Incidence of traumatic brain injury in the United States, 2003. J. Head Trauma Rehabil, 21: 544-548.
41. Ryan, L.M., J.R. O'Jile, J. Parks-Levy, B. Betz and W.D. Gouvier, 1997. Partial seizure symptomatology: Frequency in a mild head injury population. Arch. Clin. Neuropsychol., 12: 399-400.
42. Sadamoto, Y., K. Igase, M. Sakanaka, K. Sato and H. Otsuka et al., 1998. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem. Biophys. Res. Commun., 253: 26-32.
43. Sakanaka, M., T.C. Wen, S. Matsuda, S. Masuda, E. Morishita, M. Nagao and R. Sasaki, 1998. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc. Natl. Acad. Sci. USA, 95: 4635-4640.
44. Sander, J.W., Y.M. Hart, A.L. Johnson and S.D. Shorvon, 1990. National general practice study of epilepsy: Newly diagnosed epileptic seizures in a general population. Lancet, 336: 1267-1271.
45. Sasaki, R., S. Masuda and M. Nagao, 2001. Pleiotropic functions and tissue-specific expression of erythropoietin. News Physiol. Sci., 16: 110-113.
46. Sawka, M.N., M.J. Joyner, D.S. Miles, R.J. Robertson, L.L. Spriet and A.J. Young, 1996. ACSM position stand: The use of blood doping as an ergogenic aid. Med. Sci. Sports Exercise, 28: 127-134.
47. Siren, A.L., M. Fratelli, M. Brines, C. Goemans and S. Casagrande et al., 2001. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl. Acad. Sci. USA., 98: 4044-4049.
48. Siren, A.L., K. Radyushkin, S. Boretius, D. Karrrmer and C.C. Riechers et al., 2006. Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin. Brain, 129: 480-489.
49. Sosin, D.M., J.E. Sniezek and D.J. Thurman, 1996. Incidence of mild and moderate brain injury in the United States, 1991. Brain Inj, 10: 47-54.
50. Spalding, B.J., 1991. Black-market biotechnology: Athletes abuse EPO and HGH. Biotechnol. N. Y., 1050: 1052-1053.
51. Spivak, J.L., 2001. Erythropoietin use and abuse: When physiology and pharmacology collide. Adv. Exp. Med. Biol., 502: 207-224.
52. Wang, C.H., C.L. Liang, L.T. Huang, J.K. Liu, P.H. Hung, A. Sun and K.S. Hung, 2004a. Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia- ischemia rats. Biochem. Biophys. Res. Commun., 314: 1064-1071.
53. Wang, L., Z. Zhang, Y. Wang, R. Zhang and M. Chopp, 2004b. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke, 35: 1732-1737.
54. Wrightson, P. and D. Gronwall, 1998. Mild head injury in New Zealand: Incidence of injury and persisting symptoms. N. Z. Med. J., 111: 99-101.