The effects of cholera toxin on cellular energy metabolism

Toxins

Volumn 2, Issue 4, 2010, Pages 632-648

  Snider, Rachel M ^a   McKenzie, Jennifer R ^a   Kraft, Lewis ^a   Kozlov, Eugene ^a   Wikswo, John P ^a   Cliffel, David E ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Cholera toxin; Cyclic AMP; Forskolin; Metabolism; Microphysiometry; Multianalyte; PC 12

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN; CHOLERA TOXIN B SUBUNIT; CYCLIC AMP; LACTIC ACID;

ACIDIFICATION; ANAEROBIC METABOLISM; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; FIBROBLAST; LIVER CELL; OVARY CELL; OXYGEN CONSUMPTION;

ANIMALS; CHOLERA TOXIN; CYCLIC AMP; ENERGY METABOLISM; LACTIC ACID; MICROFLUIDIC ANALYTICAL TECHNIQUES; OXYGEN CONSUMPTION; PC12 CELLS; RATS;

EID: 79952082664     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2040632     Document Type: Article

References (33)

1. Sack, D.A.; Sack, R.B.; Nair, G.B.; Siddique, A.K. Cholera. Lancet 2004, 363, 223-233.
2. Finkelstein, R.A. Medical Microbiology, 4th ed.; Baron, S., Ed.; University of Texas Medical Branch: Galveston, TX, USA, 1996.
3. Olivier, V.; Salzman, N.H.; Fullner Satchell, K.J. Prolonged Colonization of Mice by Vibrio cholerae El Tor O1 Depends on Accessory Toxins. Infect. Immun. 2007, 75, 5043-5051.
4. Lundgren, O. Enteric nerves and diarrhoea. Pharmacol. Toxicol. 2002, 90, 109-120.
5. Lencer, W.I.; Tsai, B. The intracellular voyage of cholera toxin: going retro. Trends Biochem. Sci. 2003, 28, 639-645.
6. Eklund, S.E.; Thompson, R.G.; Snider, R.M.; Carney, C.K.; Wright, D.W.; Wikswo, J.; Cliffel, D.E. Metabolic discrimination of select list agents by monitoring cellular responses in a multianalyte microphysiometer. Sensors 2009, 9, 2117-2133.
7. Lencer, W.I.; Strohmeier, G.; Moe, S.; Carlson, S.L.; Constable, C.T.; Madara, J.L. Signal Transduction by cholera toxin: processing in vesicular compartments does not require acidification. Am. J. Physiol. 1995, 269, G548-G557.
8. Sanchez, J.; Holmgren, J. Cholera toxin structure, gene regulation and pathophysiological and immunological aspects. Cell. Mol. Life Sci. 2008, 65, 1347-1360.
9. Selinger, Z. Discovery of G protein signaling. Annu. Rev. Biochem. 2008, 77, 1-13.
10. Eklund, S.E.; Cliffel, D.E.; Kozlov, E.; Prokop, A.; Wikswo, J.P.; Baudenbacher, F. Modification of the Cytosensor microphysiometer to sumultaneously measure extracellular acidification and oxygen consumption rates. Anal. Chim. Acta 2003, 296, 93-101.
11. Eklund, S.E.; Kozlov, E.; Taylor, D.E.; Baudenbacher, F.; Cliffel, D.E. Real-time cell dynamics with a multianalyte physiometer. Methods Mol. Biol. 2005, 303, 209-223.
12. Eklund, S.E.; Taylor, D.; Kozlov, E.; Prokop, A.; Cliffel, D.E. A microphysiometer for simultaneous measurement of changes in extracellular glucose, lactate, oxygen, and acidification rate. Anal. Chem. 2004, 76, 519-527.
13. Eklund, S.E.; Snider, R.M.; Wikswo, J.P.; Baudenbacher, F.; Prokop, A.; Cliffel, D.E. Multianalyte microphysiometry as a tool in metabolomics and systems biology. J. Electroanal. Chem. 2006, 587, 333-339.
14. Snider, R.M.; Ciobanu, M.; Rue, A.E.; Cliffel, D.E. A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber. Anal. Chim. Acta 2008, 609, 44-52.
15. Martin, T.F.J.; Grishanin, R.N. PC12 Cells as a Model for Studies of Regulated Secretion in Neuronal and Endocrine Cells. Meth. Cell Biol. 2003, 71, 267-286.
16. Majoul, I.; Schmidt, T.; Pomasanova, M.; Boutkevich, E.; Kozlov, Y.; Söling, H.-D. Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle. J. Cell Sci. 2002, 115, 817-826.
17. Chijiwa, T.; Mishima, A.; Hagiwara, M.; Sano, M.; Inoue, T.; Naito, K.; Toshioka, T.; Hidaka, H. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pbromocinnamylamino) ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 1990, 265, 5267-5272.
18. Lencer, W.I.; Moe, S.; Rufo, P.A.; Madara, J.L. Transcytosis of cholera toxin subunits acrossmodel human intestinal epithelia. Proc. Natl. Acad. Sci. USA 1995, 92, 10094-10098.
19. Orlandi, P.A.; Curran, P.K.; Fishman, P. H. Brefeldin A Blocks the Response of Cultured Cells toCholera Toxin. J. Biol. Chem. 1993, 268, 12010-12016.
20. Mickevicius, C.K.; Harrison, J.K.; Genegy, M.E. Effect of Cholera Toxin on the Activation of Adenylate Cyclase by Calmodulin in Bovine Striatum. Mol. Pharacol. 1986, 30, 469-475.
21. Barovsky, K.; Brooker, G. Forskolin potentiation of cholera toxin-stimulated cyclic AMPaccumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling. Mol. Pharacol. 1985, 28, 502-507.
22. Burleigh, D.E.; Borman, R.A. Evidence for a nonneural electrogenic effect of cholera toxin on human isolated ileal mucosa. Dig. Dis. Sci. 1997, 42, 1964-1968.
23. Bourne, G.A. Forskolin but not cholera toxin bypasses flufenamate-induced inhibition of Camp production in anterior pituitaries. Pharmacol. Toxicol 1992, 71, 391-394.
24. Seamon, K.B.; Padgett, W.; Daly, J.W. Forskolin: Unique diterpine activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA 1981, 78, 3363-3367.
25. Owicki, J.C.; Bousse, L.J.; Hafeman, D.G.; Kirk, G.L.; Olson, J.D.; Wada, H.G.; Parce, J.W. Thelight-addressable potentiometric sensor: principles and biological applications. Annu. Rev. Biophys. Biomol. Struct. 1994, 23, 87-113.
26. Keusch, G.T.; Rahal, J.J.; Weinstein, L.; Grady, G.F. Biochemical effects of cholera enterotoxin: oxidative metabolism in the infant rabbit. Am. J. Physiol. 1970, 218, 703-707.
27. Fishman, P.H. Mechanism of Action of Cholera Toxin: Studies on the Lag Period. J. Membr.Biol. 1980, 54, 61-72.
28. Sofer, A.; Futerman, A.H. Rate of Retrograde Transport of Cholera Toxin from the Plasma Membrane to the Golgi Apparatus and Endoplasmic Reticulum Decreases During Neuronal Development. J. Neurochem. 1996, 67, 2134-2140.
29. Cassel, D.; Selinger, Z. Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site. Proc. Natl. Acad. Sci. USA 1977, 74, 3307-3311.
30. Voet, D.; Voet, J.G.; Pratt, C.W. Fundamentals of Biochemistry; John Wiley & Sons: New York, NY, USA, 2002.
31. Davies, S.P.; Reddy, H.; Caivano, M.; Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 2000, 351, 95-105.
32. Cohen, P. The Effective Use of Protein Kinase Inhibitors. Cell Trans. 2003, 19, 11-14.
33. Insel, P.A.; Ostrom, R.S. Forskolin as a Tool for Examining Adenylate Cyclase Expression,Regulation and G Protein Signaling. Cell Mol. Neurobiol. 2003, 23, 305-314.