Potential photocarcinogenic effects of nanoparticle sunscreens

Australasian Journal of Dermatology

Volumn 52, Issue 1, 2011, Pages 1-6

  Tran, Dai T ^a   Salmon, Robert ^a  

^a Illawarra Dermatology and Laser Clinic   (Australia)

Author keywords

Barrier function; Nanoparticles; Penetration; Photocatalysis; Reactive oxygen species; Sunscreens; Titanium dioxide; Zinc oxide

Indexed keywords

AMINOLEVULINIC ACID; BENZOYL PEROXIDE; BERYLLIUM; DISPERSANT; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METAL NANOPARTICLE; PENETRATION ENHANCING AGENT; QUANTUM DOT; REACTIVE OXYGEN METABOLITE; RETINOID; SALICYLIC ACID; SINGLET OXYGEN; SUNSCREEN; SUPEROXIDE; SURFACTANT; TITANIUM DIOXIDE; ZINC OXIDE;

ATOPIC DERMATITIS; CALCIUM HOMEOSTASIS; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DIFFUSION; DNA DAMAGE; DRUG ABSORPTION; DRUG CARCINOGENICITY; DRUG CYTOTOXICITY; DRUG PENETRATION; DRUG UPTAKE; ELECTRON; HUMAN; KERATINIZATION; LIGHT EXPOSURE; LIPID PEROXIDATION; MASSAGE; NONHUMAN; PARTICLE SIZE; PHAGOCYTOSIS; PHOTOCARCINOGENIC EFFECT; PHOTOCATALYSIS; PHOTODYNAMIC THERAPY; RADIATION ABSORPTION; REVIEW; SKIN ABRASION; SKIN ABSORPTION; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM; ULTRAVIOLET RADIATION; WRINKLE;

ANIMALS; CARCINOGENS; CHEMISTRY, PHARMACEUTICAL; HUMANS; NANOPARTICLES; REACTIVE OXYGEN SPECIES; SKIN; SKIN NEOPLASMS; SUNSCREENING AGENTS; TITANIUM; ZINC OXIDE;

EID: 79952063555     PISSN: 00048380     EISSN: 14400960     Source Type: Journal    
DOI: 10.1111/j.1440-0960.2010.00677.x     Document Type: Review

References (66)

1. Barker PJ, Branch A. The interaction of modern sunscreen formulations with surface coatings. Progr. Org. Coating 2008; 62: 313-20.
2. Martinez GR, Loureiro AP, Marques SA et al. Oxidative and alkylating damage in DNA. Mutat. Res. 2003; 544: 115-27. (Pubitemid 37487655)
3. Williams PL, Bannister LH, Berry MM et al. Gray's Anatomy, 38th edn. London: Churchill Livingston, 1995.
4. Oberdörster G, Oberdörster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005; 113: 823-39. (Pubitemid 40984181)
5. More BD. Physical sunscreens: on the comeback trail. Indian J. Dermatol. Venereol. Leprol. 2007; 73: 80-5. (Pubitemid 46675029)
6. Department of Health and Aging, Therapeutic Goods Administration. A Review of the Scientific Literature on the Safety of Nanoparticulate Titanium Dioxide or Zinc Oxide in Sunscreens. Available from URL: http://www.tga.gov.au/ npmeds/sunscreen-zotd.pdf. (Accessed 15 Dec 2009.)
7. Fujishima A, Rao TN, Tryk DA. Titanium dioxide photocatalysis. J. Photochem. Photobiol. C Photochem. Rev. 2000; 1: 1-21.
8. 2 and organic peroxides on quantum-sized semiconductor colloids. Environ. Sci. Technol. 1994; 28: 776-85.
9. Sclafani JA, Herrmann JM. Comparison of the photoelectronic and photocatalytic activities of various anatase and rutile forms of titania in pure liquid organic phases and in aqueous solutions. Phys. Chem. 1996; 100: 13655-61. (Pubitemid 126814695)
10. Picatonotto T, Vione D, Carlotta ME. Effect of some additives used in the cosmetic field on the photocatalytic activity of rutile. J. Disp. Sci. Technol. 2002; 23: 845-52. (Pubitemid 36209826)
11. Dondi D, Albini A, Serpone N. Interactions between different solar UVB/UVA filters contained in commercial suncreams and consequent loss of UV protection. Photochem. Photobiol. Sci. 2006; 5: 835-43. (Pubitemid 44315945)
12. 2-promoted mineralization of organic sunscreens in water suspension and sodium dodecyl sulfate micelles. Photochem. Photobiol. Sci. 2003; 2: 487-92.
13. Wakefield G, Lipscomb S, Holland E et al. The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochem. Photobiol. Sci. 2004; 3: 648-52. (Pubitemid 39139934)
14. Allen NS, Edge M, Sandoval G et al. Photocatalytic coatings for environmental applications. Photochem. Photobiol. 2005; 81: 279-90. (Pubitemid 40551503)
15. Bennat C, Muller-Goymann CC. Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter. Int. J. Cosmet. Sci. 2000; 22: 271-83. (Pubitemid 30639203)
16. Lee WA, Pernodet N, Li B et al. Multicomponent polymer coating to block photocatalytic activity of TiO2 nanoparticles. Chem. Commun. 2007; 7: 4815-17. (Pubitemid 350115362)
17. Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J. Am. Acad. Dermatol. 2005; 52: 163-4.
18. Carlotti ME, Ugazio E, Gastaldi L et al. Specific effects of single antioxidants in the lipid peroxidation caused by nano-titania used in sunscreen lotions. J. Photochem. Photobiol. B, Biol. 2009; 96: 130-5.
19. Cross SE, Innes B, Roberts MS et al. Human skin penetration of sunscreen nanoparticles: in vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol. Physiol. 2007; 20: 148-54. (Pubitemid 46788286)
20. Pflücker F, Wendel V, Hohenberg H et al. The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronized titanium dioxide. Skin Pharmacol. Appl. Skin Physiol. 2001; 14: s92-7.
21. Nohynek GJ, Lademann IC, Ribaud C et al. Goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit. Rev. Toxicol. 2007; 37: 251-77. (Pubitemid 46440572)
22. Tan MH, Commens CA, Burnett L et al. A pilot study on the percutaneous absorption of microfine TiO2 from sunscreens. Australas. J. Dermatol. 1996; 37: 185-7. (Pubitemid 126440414)
23. Gulsson B, Wong H, McCall M. Dermal absorption of ZnO nanoparticles in sunscreen using the stable isotope approach. Toxicol. Lett. 2008; 180: s222.
24. Gulson B, McCall M, Gomez L. Dermal Absorption of ZnO Particles from Sunscreens Applied to Humans at the Beach. Available from URL: http://realizebeauty.files.wordpress.com/ 2010/02/iconn2010-abstract-gulson1. pdf. (Accessed 15 Dec 2009.)
25. Mahe B, Vogt A, Liard C et al. Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice. J. Invest. Dermatol. 2009; 129: 1156-64.
26. Lademann J, Richter H, Teichmann A et al. Nanoparticles - an efficient carrier for drug delivery into the hair follicles. Eur. J. Pharm. Biopharm. 2007; 66: 159-64. (Pubitemid 46654773)
27. Wu J, Liu W, Xue C et al. Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol. Lett. 2009; 191: 1-8.
28. Fabian E, Landsiedel R, Ma-Hock L et al. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch. Toxicol. 2008; 82: 151-7.
29. Magnusson BM, Walters KA, Roberts MS. Veterinary drug delivery - part IV. Adv. Drug Deliv. Rev. 2001; 50: 205-27.
30. Tinkle SS, Antonini JM, Rich BA et al. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ. Health Perspect. 2003; 111: 1202-8. (Pubitemid 36939402)
31. Gopee NV, Roberts BW, Webb P et al. Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin. Toxicol. Sci. 2009; 111: 37-48.
32. Zhang LW, Monteiro-Riviere NA. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol. Physiol. 2008; 21: 166-80. (Pubitemid 351793745)
33. Blundell G, Henderson WJ, Price EW. Soil particles in the tissues of the foot in endemic elephantiasis of the lower legs. Ann. Trop. Med. Parasitol. 1989; 83: 381-5. (Pubitemid 19223830)
34. 2 UV Pigments. Available from URL: http://www. koboproductsinc.com/UVPigmentsTiO2.html. (Accessed 15 Dec 2009.)
35. Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol. Sci. 2006; 91: 159-65.
36. Baroli B, Ennas MG, Loffredo F et al. Penetration of metallic nanoparticles in human full-thickness skin. J. Invest. Dermatol. 2007; 12: 1701-12. (Pubitemid 46933398)
37. Honeywell-Nguyen PL, Gooris GS, Bouwstra JA. Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. J. Invest. Dermatol. 2004; 123: 902-10. (Pubitemid 39391936)
38. Aldous G, Kent P. Titanium Dioxide and Zinc Oxide Nanoparticles in Sunscreen Formulations: A Study of the Post Production Particle Size Distribution of Particles in a Range of Commercial Emulsion Variants. Hamilton Australia. Available from URL: http://www.hamiltonlabs.com.au/webdata/resources/ files/ Hamilton-Sunscreen-Nanoparticles-Paper.pdf. (Accessed 15 Dec 2009.)
39. 2 by span 60. J. Ceram. Process. Res. 2008; 9: 398-400.
40. Dussert AS, Gooris E. Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum. Int. J. Cosmet. Sci. 1997; 19: 119-29. (Pubitemid 27303816)
41. Thong HY, Zhai H, Maibach HI. Percutaneous penetration enhancers: an overview. Skin Pharmacol. Physiol. 2007; 20: 272-82. (Pubitemid 350014982)
42. Kuo TR, Wu CL, Hsu CT et al. Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles. Biomaterials 2009; 30: 3002-8.
43. Lansdown AB, Taylor A. Zinc and titanium oxides: promising UV-absorbers but what influence do they have on the intact skin? Int. J. Cosmet. Sci. 1997; 19: 167-72. (Pubitemid 27399970)
44. Waller JM, Dreher F, Behnam S et al. Keratolytic' properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man. Skin Pharmacol. Physiol. 2006; 19: 283-9. (Pubitemid 44329095)
45. Elias PM. Epidermal effects of retinoids: supramolecular observation and clinical implications. J. Am. Acad. Dermatol. 1986; 15: 797-809. (Pubitemid 17170784)
46. Brand RM, Pike J, Wilson RM et al. Sunscreens containing physical UV blockers can increase transdermal absorption of pesticides. Toxicol. Ind. Health 2003; 19: 9-16. (Pubitemid 39121061)
47. Taylor S, Diffey BL. Simple dosage guide for sunscreens will help users (Letter). BMJ 2002; 324: 1526. (Pubitemid 34666634)
48. Jiang SJ, Chen JY, Lu ZF et al. Biophysical and morphological changes in the stratum corneum lipids induced by UVB irradiation. J. Dermatol. Sci. 2006; 44: 29-36. (Pubitemid 44310988)
49. Mortensen LJ, Oberdörster G, Pentland AP et al. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett. 2008; 8: 2779-87.
50. 2 nanoparticles that may trigger toxic responses. Chem. Eur. J. 2009; 15: 4614-21.
51. Sharma V, Shukla RK, Saxena N et al. DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol. Lett. 2009; 185: 211-18.
52. Onuma K, Sato Y, Ogawara S et al. Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells. Am. J. Pathol. 2009; 175: 2171-83.
53. Dunford R, Salinaro A, Cai L et al. Chemical oxidation and DNA damage catalyzed by inorganic sunscreen ingredients. FEBS Lett. 1997; 418: 87-90. (Pubitemid 27514421)
54. Hirakawa K, Mori M, Yoshida M et al. Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radic. Res. 2004; 38: 439-47. (Pubitemid 38618365)
55. Meguro S, Arai Y, Masukawa K et al. Stratum corneum abnormalities in UVB-irradiated skin. Photochem. Photobiol. 1999; 69: 317-21. (Pubitemid 129554857)
56. 2 reaction: toward an understanding of its killing mechanism. Appl. Environ. Microbiol. 1999; 65: 4094-8.
57. Robertson CA, Hawkins D, Abrahamse H. Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. J. Photochem. Photobiol. B, Biol. 2009; 96: 1-8.
58. Borbála K, Tamás B, Gabriella C et al. Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells. Exp. Dermatol. 2008; 17: 659-67.
59. Nanoderm. Quality of Skin as a Barrier to Ultra-Fine Particles. Nanoderm Final Report. Available from URL: http://www.unileipzig.de/~nanoderm. (Accessed 15 Dec 2009.)
60. Yanagisawa R, Takano H, Inoue KI et al. Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice. Exp. Biol. Med. 2009; 234: 314-22.
61. Kambara T, Aihara M, Matsukura S et al. Effects of photocatalytic agent on DS-Nh mice, developing atopic dermatitis-like eruption with an increase of staphylococcus aureus. Int. Arch. Allergy Immunol. 2006; 141: 151-7. (Pubitemid 44413290)
62. The Royal Commission on Environment Pollution, Scientific Committee on Consumer Products (SCCP). Preliminary Opinion on the Safety of Nanomaterials in Cosmetic Products: Executive Summary. Available from URL: http://www.rcep.org. uk/reports/27-novel%20materials/documents/ EuropeanCommissionD.pdf. (Accessed 15 Dec 2009.)
63. Boyd A, Naylor M, Cameron G et al. The effects of chronic sunscreen use on the histologic changes of dermatoheliosis. J. Am. Acad. Dermatol. 1996; 35: 649-50.
64. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N. Engl. J. Med. 1993; 329: 1147-51. (Pubitemid 23295456)
65. Van Der Pols J, Williams G, Pandeya N et al. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer Epidemiol. Biomarkers Prev. 2006; 5: 2546-8. (Pubitemid 46048320)
66. Ulrich C, Jürgensen JS, Degen A. Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study. Br. J. Dermatol. 2009; 161: s78-84.