Hepatocyte differentiation of human fibroblasts from cirrhotic liver in vitro and in vivo

Hepatobiliary and Pancreatic Diseases International

Volumn 10, Issue 1, 2011, Pages 55-63

  Sun, Yu Ling ^a   Yin, Sheng Yong ^b   Zhou, Lin ^b   Xie, Hai Yang ^b   Zhang, Feng ^b   Wu, Li Ming ^b   Zheng, Shu Sen ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Fibroblasts; Hepatocytes; Mesenchymal epithelial transition

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYTOKERATIN; DESMIN; FIBRONECTIN; LIVER PROTEIN; PROPYL 4 HYDROXYLASE; RETRORSINE; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CIRRHOSIS; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PHENOTYPE; PROTEIN EXPRESSION; TISSUE ENGINEERING;

EID: 79952045421     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1499-3872(11)60008-8     Document Type: Article

References (47)

1. Azar N, Valla D, Abdel-Samad I, Hoang C, Fretz C, Sutton L, et al. Liver dysfunction in allogeneic bone marrow transplantation recipients. Transplantation 1996;62:56-61.
2. Locasciulli A, Testa M, Valsecchi MG, Vecchi L, Longoni D, Sparano P, et al. Morbidity and mortality due to liver disease in children undergoing allogeneic bone marrow transplantation: a 10-year prospective study. Blood 1997;90: 3799-3805. (Pubitemid 27473454)
3. Young HE, Steele TA, Bray RA, Hudson J, Floyd JA, Hawkins K, et al. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec 2001;264:51-62. (Pubitemid 32807666)
4. Woodbury D, Reynolds K, Black IB. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 2002;69:908-917. (Pubitemid 34984707)
5. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000;6:1282-1286.
6. Malhi H, Irani AN, Gagandeep S, Gupta S. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. J Cell Sci 2002;115:2679-2688. (Pubitemid 34846509)
7. Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, et al. Isolation and characterization of a stem cell population from adult human liver. Stem Cells 2006;24: 2840-2850. (Pubitemid 46053020)
8. Sgodda M, Aurich H, Kleist S, Aurich I, König S, Dollinger MM, et al. Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. Exp Cell Res 2007;313:2875-2886. (Pubitemid 47135604)
9. Gilgenkrantz H. Mesenchymal stem cells: an alternative source of hepatocytes? Hepatology 2004;40:1256-1259.
10. Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, et al. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004;40:1275-1284.
11. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003;21:217-227. (Pubitemid 36331764)
12. Herzlinger D. Renal interstitial fibrosis: remembrance of things past? J Clin Invest 2002;110:305-306.
13. McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007;39: 666-671. (Pubitemid 46366802)
14. Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005;33:1402-1416. (Pubitemid 41541969)
15. Brendel C, Kuklick L, Hartmann O, Kim TD, Boudriot U, Schwell D, et al. Distinct gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes. Gene Expr 2005;12:245-257. (Pubitemid 41729057)
16. Ishii M, Koike C, Igarashi A, Yamanaka K, Pan H, Higashi Y, et al. Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts. Biochem Biophys Res Commun 2005;332:297-303. (Pubitemid 40719486)
17. Rutherford RB, Gu K, Racenis P, Krebsbach PH. Early events: the in vitro conversion of BMP transduced fibroblasts to chondroblasts. Connect Tissue Res 2003;44:117-123.
18. Rutherford RB, Moalli M, Franceschi RT, Wang D, Gu K, Krebsbach PH. Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng 2002;8:441-452. (Pubitemid 34747801)
19. Shui C, Scutt AM. Mouse embryo-derived NIH3T3 fibro-blasts adopt an osteoblast-like phenotype when treated with 1alpha,25-dihydroxyvitamin D(3) and dexamethasone in vitro. J Cell Physiol 2002;193:164-172.
20. Wells RG. Cellular sources of extracellular matrix in hepatic fibrosis. Clin Liver Dis 2008;12:759-768, viii.
21. Larsson O, Diebold D, Fan D, Peterson M, Nho RS, Bitterman PB, et al. Fibrotic myofibroblasts manifest genome-wide derangements of translational control. PLoS One 2008;3: e3220.
22. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;134:1655-1669. (Pubitemid 351615417)
23. Plotkin MD, Goligorsky MS. Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin-producing fibroblasts. Am J Physiol Renal Physiol 2006;291:F902-912.
24. Sabatini F, Petecchia L, Tavian M, Jodon de Villeroché V, Rossi GA, Brouty-Boyé D. Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest 2005;85:962-971. (Pubitemid 41486421)
25. Sheng W, Wang G, La Pierre DP, Wen J, Deng Z, Wong CK, et al. Versican mediates mesenchymal-epithelial transition. Mol Biol Cell 2006;17:2009-2020. (Pubitemid 44011614)
26. Dezso K, Jelnes P, László V, Baghy K, Bödör C, Paku S, et al. Thy-1 is expressed in hepatic myofibroblasts and not oval cells in stem cell-mediated liver regeneration. Am J Pathol 2007;171:1529-1537. (Pubitemid 350158314)
27. Lysy PA, Smets F, Sibille C, Najimi M, Sokal EM. Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation. Hepatology 2007;46:1574-1785.
28. Laconi S, Curreli F, Diana S, Pasciu D, De Filippo G, Sarma DS, et al. Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J Hepatol 1999;31:1069-1074.
29. Gordon GJ, Coleman WB, Hixson DC, Grisham JW. Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am J Pathol 2000;156:607-619. (Pubitemid 30643816)
30. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115: 209-218. (Pubitemid 40385459)
31. Saalbach A, Wetzig T, Haustein UF, Anderegg U. Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum. Cell Tissue Res 1999;298:307-315.
32. Forbes SJ, Russo FP, Rey V, Burra P, Rugge M, Wright NA, et al. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004;126:955-963.
33. Suskind DL, Muench MO. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol 2004;40:261-268. (Pubitemid 38115831)
34. Bussolati B, Bruno S, Grange C, Buttiglieri S, Deregibus MC, Cantino D, et al. Isolation of renal progenitor cells from adult human kidney. Am J Pathol 2005;166:545-555. (Pubitemid 40189050)
35. Katz AJ, Tholpady A, Tholpady SS, Shang H, Ogle RC. Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells 2005;23:412-423. (Pubitemid 40404460)
36. Yu Y, Fuhr J, Boye E, Gyorffy S, Soker S, Atala A, et al. Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells 2006;24:1605-1612. (Pubitemid 44464678)
37. Sicklick JK, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, et al. Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol 2006;291:G575-G583.
38. Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007;282:23337-23347. (Pubitemid 47311952)
39. Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelial-tomesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007;282:22089-22101. (Pubitemid 47195788)
40. Prindull G, Zipori D. Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm. Blood 2004;103:2892-2899. (Pubitemid 38451657)
41. Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994;127:2021-2036.
42. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002;110:341-350. (Pubitemid 34847966)
43. Ishii T, Yasuchika K, Fujii H, Hoppo T, Baba S, Naito M, et al. In vitro differentiation and maturation of mouse embryonic stem cells into hepatocytes. Exp Cell Res 2005;309:68-77.
44. Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999;284:1998-2003. (Pubitemid 29309449)
45. Lindroos PM, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991;13:743-750.
46. Suzuki A, Iwama A, Miyashita H, Nakauchi H, Taniguchi H. Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 2003;130:2513-2524. (Pubitemid 36722401)
47. Forte G, Minieri M, Cossa P, Antenucci D, Sala M, Gnocchi V, et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 2006;24:23-33.