Synthesis and comparative anti-tubercular activity of indolizine derivatives of Isoniazid / Pyrazinamide / Ethionamide

International Journal of Pharmaceutical Sciences Review and Research

Volumn 6, Issue 2, 2011, Pages 128-131

  Lingala, Srikanth ^a   Nerella, Raghunandan ^b   Cherukupally, Ratnakar ^c   Das, Amit K ^d  

^a ST PETER'S INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^b Balaji Institute of Pharmaceutical Sciences   (India)

^c Gurunanak Institute of Pharmaceutical Sciences   (India)

^d ACHARYA AND B M REDDY COLLEGE OF PHARMACY   (India)

Author keywords

Ethionamide; Indolizines; Isoniazid; Pro drugs; Pyrazinamide

Indexed keywords

CIPROFLOXACIN; ETHIONAMIDE; INDOLIZINE DERIVATIVE; ISONIAZID; N (2 ETHYLPYRIDINE 4 CARBOTHIOYL)INDOLOZINE 1 CARBOXAMIDE; N (PYRAZINE 2 CARBONYL)INDOLIZINE 1 CARBOXAMIDE; N' (PYRIDINE 4 CARBONYL)INDOLIZINE 1 CARBOHYDRAZIDE; PYRAZINAMIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GROWTH INHIBITION; MICROBIAL GROWTH; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 79952044588     PISSN: None     EISSN: 0976044X     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. William HB, Doerge RF. Mannich bases from 2-Phenylindolizines-I. J Pharm Sci 1967 Feb; 56(2): 225-8.
2. Swinborne FJ, Hunt JH, Klinkert G. Adv Heterocyclic Chemistry 1978; 23: 103-7.
3. Kalman RK, Doerge RF. p-substituted 1, 2-Diphenylindolizines as anti-inflammatory agents. J pharm Sci 1972 June; 61(6): 949-51.
4. De AU, Saha BP. Indolizines II: search for potential oral hypoglycemic agents. J Pharm Sci 1975 Feb; 64(2): 249-52.
5. De AU, Saha BP. Search for potential oral hypoglycemic agents. J Pharm Sci 1973 Nov; 62(11): 1897-8.
6. Jose B, Fake CS, Joiner GF, Kini FD, Miner WD, Sanger GJ. 5HT3 receptor antagonists, indazole and indolizine-3-carboxylic acid derivatives. J Med Chem 1987; 30: 2317-9.
7. Ippolito A, Claudi F, Gulini U, Micossi L, Venture F. Indolizine derivatives with biological activity for 3-(2-aminoethyl)-2-methylindolizine and their N-alkyl derivatives. J Pharm Sci 1979 March; 68(3): 321-4.
8. William HB, Doerge RF. Mannich bases from 2-Phenylindolizines-II. J Pharm Sci 1967 Sep; 56(9): 1200-2.
9. Jorgenson AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Susan M T et al. Synthesis and estrogen binding activities of novel pyrrolo(2,1,5-cd)indolizine derivatives. Bioorg and Med Chem Lett 2000; 10: 2383-6.
10. Ostby OB, Dalhus B, Gundersen LL, Rise F, Bast A et al. Synthesis of 1-substituted-7-cyano-2,3-diphenylindolizines and evaluation of Antioxidant properties. Eur J Org Chem 2003; 37: 63-70.
11. Baidya M, Das AK. Synthesis and pharmacological screening of some indolizinamido glutamine derivatives. Ind J Het Chem 2004 jul; 14(9): 81-2.
12. Mukerjee I, Das AK. Synthesis and antimicrobial activity of mannich bases of indolizine analogues. Orient J Chem 2006; 22(2): 339-42.
13. Das AK, Som S. Synthesis and evaluation of some 3-benzoylindolizine-1-carboxamides as possible antiinflammatory and analgesic agents. Orient J Chem 2006; 22(2): 415-20.
14. P. Olejníkova, L. Birošová, L. Švorc, Antimicrobial and Antimutagenic Properties of Newly Synthesized Derivatives of Indolizine. Sci Pharm. 2009; 77: 216.
15. Wani MC, Nicholas AW, Wall ME. Plant antitumor agents. J Med Chem 1987; 30: 2317-9.
16. Gunderson LL, Neguisse AH, Rise F. Mycobacterial activity of 1-Substituted indolizine. Archiv der pharmazie, 2002 Nov; 336(6):191-5.
17. Gundersen, L.-L; Charnock, C.; Negussie, A. H.; Rise, F.; Teklu, S.; Synthesis of Indolizine Derivatives with Selective Antibacterial Activity against Mycobacterium tuberculosis. Eur. J. Pharm. Sci. 2007; 30: 26-35.
18. Lande Z, Feng L, Lingzhi S, Yuefei H, Hongwen H. A Novel and Practical Synthesis of 3-Unsubstituted Indolizines. Synthesis 2000; 12: 1733-7.
19. Bingxiang W, Xuechun Z, Li J, Jiang X, Yuefei H, Hongwen H. Preparation of indolizine-3-carboxamides and indolizine-3-carbonitriles by 1,3-dipolar cycloaddition. J Chem Soc, Perkin Trans I 1999: 1571-5.
20. Vijaya B Reddy, Rajeev K Singla Varadaraj Bhat G, and Gautham G Shenoy, Synthesis and Antimicrobial Studies Of Some Novel Benzimidazole Derivatives Asian J. Research Chem. 2009; 2(2): 162-167.
21. Mojahidul Islam, Anees A Siddiqui, Ramadoss Rajesh, Afroz Bakht And Sunil Goyal, Synthesis And Antimicrobial Activity Of Some Novel Oxadiazole Derivatives Acta Poloniae Pharmaceutica- Drug Research, 2008; 65: 441-447.
22. Warnock DW. Methods with antifungal drugs. In: Evans E G and Richrdson M D. (Eds.) Medical Mycology: A Practical Approach, Oxford University, 1991; 179-200.