A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action

Biomaterials

Volumn 32, Issue 13, 2011, Pages 3351-3357

  Dowling, Matthew B ^a   Kumar, Rakesh ^a   Keibler, Mark A ^a   Hess, John R ^b   Bochicchio, Grant V ^b   Raghavan, Srinivasa R ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Amphiphilic biopolymer; Chitosan; Cyclodextrin; Hemostasis; Self assembly

Indexed keywords

AMPHIPHILIC BIOPOLYMER; AMPHIPHILICS; BLEEDING TIME; BLOOD CELLS; BLOOD LOSS; CELL NETWORK; FEMORAL VEIN; HEMOSTASIS; HUMAN BLOODS; HYDROPHOBES; HYDROPHOBIC POCKETS; HYDROPHOBICALLY MODIFIED CHITOSAN; INJURY MODELS; LIQUID STATE; RAT MODEL; SELF-ASSEMBLED NETWORKS; SELF-ASSEMBLING; SUPRAMOLECULES;

BIOMOLECULES; CELLS; CHITIN; CHITOSAN; COAGULATION; CYCLODEXTRINS; GELATION; GELS; LIQUID SUGAR; MAMMALS; SELF ASSEMBLY; SILANES; SUGARS;

BLOOD;

ALPHA CYCLODEXTRIN; BIOPOLYMER; CHITOSAN DERIVATIVE; HEMOSTATIC AGENT; HM CHITOSAN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; BLOOD; CHEMICAL MODIFICATION; CONTROLLED STUDY; ERYTHROCYTE MEMBRANE; EXPERIMENTAL PIG; FEMALE; FEMORAL VEIN; GELATION; HEMOSTASIS; HUMAN; HYDROPHOBICITY; LIQUID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VEIN INJURY;

ADULT; ANIMALS; BIOPOLYMERS; CHITOSAN; CYCLODEXTRINS; FEMALE; HEMOSTASIS; HEMOSTATICS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; RATS; RATS, LONG-EVANS; SWINE; YOUNG ADULT;

ANIMALIA; MAMMALIA; RATTUS;

EID: 79952041390     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.12.033     Document Type: Article

References (30)

1. Owen C.A. A history of blood coagulation 2001, Mayo Foundation, Rochester, MN.
2. Macfarlane R.G. An enzyme cascade in the blood clotting mechanism, and its function as a biological amplifier. Nature 1964, 202:498-499.
3. Smith G.F. Fibrinogen-fibrin conversion - mechanism of fibrin-polymer formation in solution. Biochem J 1980, 185:1-11.
4. Doolittle R.F. Fibrinogen and fibrin. Annu Rev Biochem 1984, 53:195-229.
5. Neuffer M.C., McDivitt J., Rose D., King K., Cloonan C.C., Vayer J.S. Hemostatic dressings for the first responder: a review. Mil Med 2004, 169:716-720.
6. Larson M.J., Bowersox J.C., Lim R.C., Hess J.R. Efficacy of a fibrin hemostatic bandage in controlling hemorrhage from experimental arterial injuries. Arch Surg 1995, 130:420-422.
7. Reiss R.F., Oz M.C. Autologous fibrin glue: production and clinical use. Transfus Med Rev 1996, 10:85-92.
8. Champion H.R., Bellamy R.F., Roberts C.P., Leppaniemi A. A profile of combat injury. J Trauma 2003, 54:S13-S19.
9. Stewart R.M., Myers J.G., Dent D.L., Ermis P., Gray G.A., Villarreal R., et al. Seven hundred fifty-three consecutive deaths in a level 1 trauma center: the argument for injury prevention. J Trauma 2003, 54:66-70.
10. Kauvar D.S., Lefering R., Wade C.E. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma 2006, 60:S3-S9.
11. Kheirabadi B.S., Acheson E.M., Deguzman R., Sondeen J.L., Ryan K.L., Delgado A., et al. Hemostatic efficacy of two advanced dressings in an aortic hemorrhage model in swine. J Trauma 2005, 59:25-34.
12. Pusateri A.E., Holcomb J.B., Kheirabadi B.S., Alam H.B., Wade C.E., Ryan K.L. Making sense of the preclinical literature on advanced hemostatic products. J Trauma 2006, 60:674-682.
13. Arnaud F., Teranishi K., Tomori T., Carr W., McCarron R. Comparison of 10 hemostatic dressings in a groin puncture model in swine. J Vasc Surg 2009, 50:632-639.
14. Kheirabadi B.S., Scherer M.R., Estep J.S., Dubick M.A., Holcomb J.B. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma 2009, 67:450-460.
15. Bochicchio G., Kilbourne M., Kuehn R., Keledjian K., Hess J., Scalea T. Use of a modified chitosan dressing in a hypothermic coagulopathic grade V liver injury model. Am J Surg 2009, 198:617-622.
16. Ellis-Behnke R.G., Liang Y.-X., Tay D.K.C., Kau P.W.F., Schneider G.E., Zhang S., et al. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine 2006, 2:207-215.
17. Ellis-Behnke R.G., Liang Y.X., You S.W., Tay D.K.C., Zhang S.G., So K.F., et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A 2006, 103:5054-5059.
18. Lew W.K., Weaver F.A. Clinical use of topical thrombin as a surgical hemostat. Biologics 2008, 2:593-599.
19. Kean T., Thanou M. Biodegradation, biodistribution and toxicity of chitosan. Adv Drug Deliv Rev 2010, 62:3-11.
20. Desbrieres J., Martinez C., Rinaudo M. Hydrophobic derivatives of chitosan: characterization and rheological behaviour. Int J Biol Macromol 1996, 19:21-28.
21. Lee J.H., Gustin J.P., Chen T.H., Payne G.F., Raghavan S.R. Vesicle-biopolymer gels: networks of surfactant vesicles connected by associating biopolymers. Langmuir 2005, 21:26-33.
22. Malette W.G., Quigley H.J., Gaines R.D., Johnson N.D., Rainer W.G. Chitosan: a new hemostatic. Ann Thorac Surg 1983, 36:55-58.
23. Rao S.B., Sharma C.P. Use of chitosan as a biomaterial: studies on its safety and hemostatic potential. J Biomed Mater Res 1997, 34:21-28.
24. Whang H.S., Kirsch W., Zhu Y.H., Yang C.Z., Hudson S.M. Hemostatic agents derived from chitin and chitosan. J Macromol Sci Polym Rev 2005, C45:309-323.
25. Szejtli J. Introduction and general overview of cyclodextrin chemistry. Chem Rev 1998, 98:1743-1753.
26. Tonelli A.E. Nanostructuring and functionalizing polymers with cyclodextrins. Polymer 2008, 49:1725-1736.
27. Raghavan S.R., Cipriano B.H. Gel formation: phase diagrams using tabletop rheology and calorimetry. Molecular gels 2005, 233-244. Springer, Dordrecht. R.G. Weiss, P. Terech (Eds.).
28. Macosko C.W. Rheology: principles, measurements and applications 1994, VCH Publishers, New York.
29. Meier W., Hotz J., GuntherAusborn S. Vesicle and cell networks: interconnecting cells by synthetic polymers. Langmuir 1996, 12:5028-5032.
30. Kumar R., Raghavan S.R. Thermothickening in solutions of telechelic associating polymers and cyclodextrins. Langmuir 2010, 26:56-62.