High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt

Diabetes Research and Clinical Practice

Volumn 91, Issue 2, 2011, Pages 177-182

  Liu, S ^a   Li, Y ^a   Lin, T ^a   Fan, X ^a   Liang, Y ^a   Heemann, U ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bladder cancer; Glargine; Insulin; Proliferation

Indexed keywords

HUMAN INSULIN; INSULIN GLARGINE; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR;

ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; ENZYME ACTIVATION; HUMANS; INSULIN; INSULIN, LONG-ACTING; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 79952040821     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.11.009     Document Type: Article

References (28)

1. Larsson S.C., Orsini N., Brismar K., Wolk A. Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia 2006, 49(12):2819-2823.
2. Larsson S.C., Orsini N., Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 2005, 97:1679-1687.
3. Huxley R., Ansary-Moghaddam A., Berrington, de González A., Barzi F., Woodward M. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 2005, 2:2076-2083.
4. Friberg E., Orsini N., Mantzoros C.S., Wolk A. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia 2007, 50:1365-1374.
5. Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8(12):915-928.
6. Osborne C.K., Bolan G., Monaco M.E., Lippman M.E. Hormone responsive human breast cancer in long-term tissue culture: effect of insulin. Proc Natl Acad Sci USA 1976, 73:4536-4540.
7. Heuson J.C., Legros N. Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction. Cancer Res 1972, 32:226-232.
8. Kido Y., Nakae J., Accili D. Clinical review 125: the insulin receptor and its cellular targets. J Clin Endocrinol Metab 2001, 86:972-979.
9. Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
10. Mayer D., Shukla A., Enzmann H. Proliferative effects of insulin analogues on mammary epithelial cells. Arch Physiol Biochem 2008, 114(1):38-44.
11. Hemkens L.G., Grouven U., Bender R., Günster C., Gutschmidt S., Selke G.W., et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 2009, 52(9):1732-1744.
12. Kurtzhals P., Schäffer L., Sørensen A., Kristensen C., Jonassen I., Schmid C., et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 2000, 49:999-1005.
13. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249.
14. Sorimachi K., Yasumura Y., Kakuya T., Okayasu T. Up-regulation of insulin receptors with dexamethasone in cultured human urinary bladder carcinoma cells. Endocrinol Jpn 1983, 30(6):723-729.
15. Rochester M.A., Patel N., Turney B.W., Davies D.R., Roberts I.S., Crew J., et al. The type 1 insulin-like growth factor receptor is over-expressed in bladder cancer. BJU Int 2007, 100(6):1396-1401.
16. Staiger K., Hennige A.M., Staiger H., Häring H.U., Kellerer M. Comparison of the mitogenic potency of regular human insulin and its analogue glargine in normal and transformed human breast epithelial cells. Horm Metab Res 2007, 39(1):65-67.
17. Wada T., Azegami M., Sugiyama M., Tsuneki H., Sasaoka T. Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin. Diabetes Res Clin Pract 2008, 81(3):269-277.
18. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270(5240):1326-1331.
19. Boulton T.G., Nye S.H., Robbins D.J., Ip N.Y., Radziejewska E., Morgenbesser S.D., et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991, 65(4):663-675.
20. Segal R.A., Greenberg M.E. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 1996, 19:463-489.
21. Mebratu Y., Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer. Cell Cycle 2009, 8(8):1168-1175.
22. Rundén E., Seglen P.O., Haug F.M., Ottersen O.P., Wieloch T., Shamloo M., et al. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J Neurosci 1998, 18(18):7296-7305.
23. Lee E.R., Kang Y.J., Kim J.H., Lee H.T., Cho S.G. Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem 2005, 280(36):31498-31507.
24. Park J.I., Strock C.J., Ball D.W., Nelkin B.D. The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol 2003, 23(2):543-554.
25. Weinstein D., Simon M., Yehezkel E., Laron Z., Werner H. Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev 2009, 25(1):41-49.
26. Kim D.I., Lee S.J., Lee S.B., Park K., Kim W.J., Moon S.K. Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis 2008, 29(9):1701-1709.
27. Ornelas I.M., Ventura A.L. Involvement of the PI3K/AKT pathway in ATP-induced proliferation of developing retinal cells in culture. Int J Dev Neurosci 2010, 28(6):503-511.
28. Barragán M., de Frias M., Iglesias-Serret D., Campàs C., Castaño E., Santidrián A.F., et al. Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}. J Leukoc Biol 2006, 80(6):1473-1479.