An AMS method to determine analyte recovery from pharmacokinetic studies with concomitant extravascular and intravenous administration

Bioanalysis

Volumn 3, Issue 4, 2011, Pages 407-410

  Lappin, Graham ^a   Seymour, Mark ^a   Young, Graeme ^b   Higton, David ^c   Hill, Howard M ^d  

^a Xceleron Ltd   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14;

ACCELERATOR MASS SPECTROMETRY; ARTICLE; DISTRIBUTION VOLUME; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; STANDARDIZATION; ULTRAVIOLET RADIATION;

DRUG ADMINISTRATION ROUTES; HUMANS; ISOTOPES; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; REFERENCE STANDARDS; SPECTROPHOTOMETRY, ULTRAVIOLET; VEINS;

EID: 79952018268     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.6     Document Type: Article

References (8)

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7. Madan A, O'Brien Z, Wen J et al. A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects. Br. J. Clin. Pharmacol. 67(3), 288-298 (2008).
8. Zhou XJ, Garner RC, Nicholson S, Kissling CJ, Mayers D. Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects. J. Clin. Pharmacol. 49(12), 1408-16 (2009).