Comparison of immunogenicity and porcine-to-rhesus lamellar corneal xenografts survival between fresh preserved and dehydrated porcine corneas

Xenotransplantation

Volumn 18, Issue 1, 2011, Pages 46-55

  Li, Aipeng ^a   Pan, Zhiqiang ^a   Jie, Ying ^a   Sun, Yajie ^a   Luo, Fei ^a   Wang, Li ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

cornea; lamellar keratoplasty; pig; rhesus; xenotransplantation antigenicity

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TRIAMCINOLONE ACETONIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA CELL; CORNEA TRANSPLANTATION; DELAYED HYPERSENSITIVITY; EOSINOPHIL; GRAFT REJECTION; GRAFT SURVIVAL; HETEROTOPIC TRANSPLANTATION; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOGENICITY; IN VIVO STUDY; INFLAMMATORY INFILTRATE; KERATOPLASTY; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLIT LAMP;

ANIMALS; CORNEA; CORNEAL TRANSPLANTATION; GRAFT SURVIVAL; HUMANS; MACACA MULATTA; MALE; MICE; MICE, INBRED BALB C; PRESERVATION, BIOLOGICAL; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 79952013111     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2011.00626.x     Document Type: Article

References (20)

1. Gomaa A, Comyn O, Liu C,. Keratoprostheses in clinical practice-a review. Clin Exp Ophthalmol 2010; 38: 211-224.
2. Streilein JW,: Immune response and the eye. Chem Immunol, 1st edn. Basel: Karger, 1999.
3. Feng ST, Mu YL, Zhang L,. Laboratory rearing and germ plasma characteristics of Chinese mini-pigs. Lab Anim Sci Manage 2003; 20: 7-12.
4. Lee HI, Kim MK, Ko JH, et al. The characteristics of porcine cornea as a xenograft. J Korean Ophthalmol Soc 2006; 47: 2020-2029.
5. Yang J, Zeng YJ, Huang K, et al. Biomechanical properties of human and porcine cornea. Chin J Biomed Eng 2001; 20: 166-169.
6. Shimazaki J,. The evolution of lamellar keratoplasty. Curr Opin Ophthalmol 2000; 11: 217-223. (Pubitemid 30490798)
7. Maier P, Reinhard T,. Keratoplasty: laminate or penetrate? Part 2: lamellar keratoplasty. Ophthalmologe 2009; 106: 649-662.
8. Sweebe EC, Dohlman CH,. Nonviable donor material for lamellar keratoplasty. Arch Ophthalmol 1961; 66: 343-346.
9. Zhu X, Yin Y, Liu X, et al. Study on tissue viability of corneal and corneoscleral grafts in long term storage with dehydrated calcium chloride. Chin Ophthalmol Res 2002; 20: 135-138. (Pubitemid 34437146)
10. Guidance for Industry: Source Animal, Product, Preclinical, and Clinical Issues Concerning the Use of Xenotransplantation Products in Humans, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research (CBER), April 2003. Available at: [accessed on 09 February 2011].
11. Weijtens O, Feron EJ, Schoemaker RC, et al. High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection. Am J Ophthalmol 1999; 128: 192-197. (Pubitemid 29379772)
12. Thompson P, Xu D, Brunette I, et al. Combined effect of rapamycin and cyclosporine in the prevention of rat corneal allograft rejection. Transplant Proc 1998; 30: 1033-1035. (Pubitemid 28309469)
13. Whitcher JP, Srinivasan M, Upadhyay MP,. Corneal blindness: a global perspective. Bull World Health Organ 2001; 79: 214-221. (Pubitemid 32246479)
14. Pan Z, Sun C, Jie Y, et al. WZS-pig is a potential donor alternative in corneal xenotransplantation. Xenotransplantation 2007; 14: 603-611.
15. Werblin TP, Kaufman HE,. Epiteratophakia: the feasibility of xenografts. Cornea 1982; 1: 53-56.
16. Tanaka K, Streilein JW,. Immunobiology of xenogeneic cornea grafts in mouse eyes: II. Immunogenicity of xenogeneic cornea tissue grafts implanted in anterior chamber of mouse eyes. Transplantation 2000; 69: 616-623. (Pubitemid 30129598)
17. Kamiya K, Hori J, Kagaya F, et al. Preservation of donor cornea prevents corneal allograft rejection by inhibiting induction of alloimmunity. Exp Eye Res 2000; 70: 737-743.
18. Simon M, Fellner P, Ei-Shabrawi Y, et al. Influence of donor storage time on corneal allograft survival. Ophthamology 2004; 111: 1534-1538. (Pubitemid 39030808)
19. Oh JY, Kim MK, Ko JH, et al. Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation. Vet Ophthalmol 2009; 12: 78-82.
20. Abdelkader A, Elewah EL-SM, Kaufman HE,. Confocal microscopy of corneal wound healing after deep lamellar keratoplasty in rabbits. Arch Ophthalmol 2010; 128: 75-80.