Shenmai injection inhibiting the extracellular signal regulated kinase-induced human airway smooth muscle proliferation in asthma

Chinese Journal of Integrative Medicine

Volumn 16, Issue 4, 2010, Pages 331-336

  Zhao, Li Min ^a   Ma, Li Jun ^a   Zhang, Luo Xian ^a   Wu, Ji Zhen ^a  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Airway remodeling; Airway smooth muscle cells; Extracellular signal regulated kinase; Shenmai injection

Indexed keywords

CHINESE DRUG; CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SHENMAI; UNCLASSIFIED DRUG; HERBACEOUS AGENT; SHENGMAISAN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; ADOLESCENT; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; ENZYMOLOGY; INJECTION; METABOLISM; MIDDLE AGED; PATHOLOGY; WESTERN BLOTTING;

ADOLESCENT; ADULT; ASTHMA; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INJECTIONS; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PROLIFERATING CELL NUCLEAR ANTIGEN; YOUNG ADULT;

EID: 79952011458     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-010-0505-1     Document Type: Article

References (28)

1. Rodrigo GJ, Rodrigo C, Hall JB. Acute asthma in adults. Chest 2004;125:1081-1102.
2. Boxall C, Holgate ST, Davies DE. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir 2006;27:208-229. (Pubitemid 43092684)
3. Covar RA, Cool C, Szefler SJ. Progression of asthma in childhood. J Allergy Clin Immunol 2005;115:700-707. (Pubitemid 40460842)
4. Fredberg JJ. Bronchospasm and its biophysical basis in airway smooth muscle. Respir Res 2004;5:2-23.
5. Fahy JV, Corry DB, Boushey HA. Airway inflammation and remodelling in asthma. Curr Opin Pulm Med 2000;6:15-20.
6. Seow CY, Schellenberg RR, Pare PD. Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am J Respir Crit Care Med 1998;158:S179-S186. (Pubitemid 28536588)
7. Rubinfeld H, Seger R. The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol 2005;31:151-174. (Pubitemid 41306584)
8. Davids RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993;268:14553-14556.
9. Guan XJ, Zhang WX, Su MS, Wang ZM, Li CC, Ye LP, et al. Role of ERK signal transduction pathway in rats airway remodelling. Chin J Immunol (Chin) 2007;11:1026-1030.
10. Laporte JC, Moore PE, Baraldo S, Jouvin MH, Church TL, Schwartzman IN, et al. Direct efforts of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 2001;164:141-148. (Pubitemid 33151311)
11. Johnson PR, Black JL, Carlin S, Ge Q, Underwood PA. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am J Respir Crit Care Med 2000;162:2145-2151. (Pubitemid 32051678)
12. Black JL, Johnson PR. What determines asthma phenotype? Is it the interaction between allergy and the smooth muscle? Am J Respir Crit Med 2000;161:207-210.
13. Xu SY, Xu YJ, Zhang ZX, Ni W, Chen SX. Contribution of protein kinase C to passively sensitized human airway smooth muscle cells proliferation. Chin Med J 2004;117:30-36. (Pubitemid 38240226)
14. Zhao LM, Xu YJ, Zhang ZX, Ni W, Chen SX. The effect of passive sensitization on the activity and expression of KV channel in human bronchial smooth muscle cells. Chin Med J 2004;11:1630-1636.
15. Niu RJ, Fu J, Liu HG. Effect of Shenmai Injection and aminophylline on small airway smooth muscle cell apoptosis and related gene expression in rats with emphysema. Chin J Integr Tradit West Med (Chin) 2002;22:40-42.
16. Zhao LM, Xiong SD, Niu RJ, Xu YJ. Effect of Shenmai Injection on L-type calcium current of diaphragmatic muscle in rats. Chin J Integr Tradit West Med (Chin) 2003;8:599-602.
17. Chinese Society of Respiratory Diseases, Chinese Medical Association. Guidelines for prevention and treatment of bronchial asthma. Chin J Tuberc Respir Dis (Chin) 2008;3:177-185.
18. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997;9:180-186. (Pubitemid 27135985)
19. Matthew PH, Lynm M, Dilys L, Hirst SJ. Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle. Am J Respir Crit Care Med 2001;164:688-697. (Pubitemid 32801678)
20. Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998;31:152-161.
21. Jung JR, Kim H, Jeun SS, Lee JY, Koh EJ, Ji C. The phosphorylation status of merlin is important for regulating the RES-ERK pathway. Mol Cells 2005; 20:196-200.
22. Bhagavathula N, Kelley EA, Reddy M, Suzuki N, Shimosegawa T. Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells. World J Gastroenterol 2005;11:6144-6151. (Pubitemid 43085056)
23. Zhao YL, Liu J, Li L, Liu L, Wu L. Role of Ras/PKCzeta/ MEK/ERK1/2 signaling pathway in angiotensin II-induced vascular smooth muscle cell proliferation. Regul Pept 2005;128:43-50. (Pubitemid 40255533)
24. Cui JJ, Zhu YJ, Wu MD. Application of Shenmai Injection in clinic. China Pharmacist (Chin) 2004;7:305-307.
25. Ye DJ, Wu P, Niu RJ. Experimental study on effect of Shenmai Injection in improving contractility of fatigue diaphragm in rats. Chin J Integr Tradit West Med (Chin) 2000;20:679-681.
26. Wang C, Hu G, Liu Y, Zhou Q, Shao G, Li YL. Influence of ginsenosides on contractility of fatigued diaphragm in rats. J Bengbu Med Coll (Chin) 2005;30:121-123.
27. Zhang LJ, Zhang WJ, He LH. Study on effect of Shenmai Injection on immunologic function of patients with bronchial asthma. J Liaoning Coll Tradit Chin Med (Chin) 2006;8(3):79.
28. Luo YN, Niu RJ, Liu XS, Xu YJ. Effect of Shenmai Injection on the activity of calcium channels in airway smooth muscle cells of rat model with asthma. J Intern Intensive Med (Chin) 2008;14:300-302.