Xenotransplantation of mitochondrial electron transfer enzyme, ndi1, in myocardial reperfusion injury

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Perry, Cynthia N ^a,b   Huang, Chengqun ^b   Liu, Wayne ^b   Magee, Najib ^b   Carreira, Raquel ^b   Gottlieb, Roberta A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYBRID PROTEIN; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE QUINONE INTERNAL OXIREDUCTASE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; NDI1 PROTEIN, S CEREVISIAE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SACCHAROMYCES CEREVISIAE PROTEIN; TAT PEPTIDE (1 9), HUMAN IMMUNODEFICIENCY VIRUS 1; TAT PEPTIDE (1-9), HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; ELECTRON TRANSPORT; ENZYME LOCALIZATION; ENZYME REPLACEMENT; EX VIVO STUDY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HETEROLOGOUS EXPRESSION; IN VITRO STUDY; ISOLATED HEART; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOLECULAR THERAPY; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TRANSDUCTION; RAT; REPERFUSION INJURY; RESPIRATORY CHAIN; SACCHAROMYCES CEREVISIAE; ANIMAL; CELL CULTURE; CELL DEATH; CHEMISTRY; EVALUATION; GENE THERAPY; GENE TRANSFER; GENETICS; HEART MITOCHONDRION; HEART MUSCLE CELL; METABOLISM; METHODOLOGY; PATHOLOGY; TISSUE DISTRIBUTION; XENOGRAFT;

MAMMALIA; RATTUS;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELLS, CULTURED; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; GENE THERAPY; GENE TRANSFER TECHNIQUES; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; RATS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 79951976630     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016288     Document Type: Article

References (42)

1. Hirst J, Carroll J, Fearnley IM, Shannon RJ, Walker JE, (2001) The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim Biophys Acta 2003 Jul 10;1604 (3): 135-50.
2. Walker JE, (1992) The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. Q Review Biophys 25 (3): 253-324.
3. Janssen RJ, Van den Heuvel LP, Smeitink JA, (2004) Genetic detects in the oxidative phosphorylation (OXPHOS) system. Expert Rev Mol Diagn 4: 143.
4. Ambrosio G, Zweier JL, Flaherty JT, (1991) The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion. J Mol Cell Cardiol 23: 1359-1374.
5. Hess ML, Manson NH, (1994) Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol 16: 969-985.
6. Das DK, (1994) Cellular biochemical and molecular aspects of reperfusion injury. Ann N Y Acad Sci 723: 116-127.
7. Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ, (2000) Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192: 1001-1014.
8. Yagi T, (1991) Bacterial NADH-quinone oxidoreductase. J Bioeng Biomem 23: 211-225.
9. de Vries S, Grivell LA, (1988) Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae. Eur J Biochem 176: 377-384.
10. Marres CAM, de Vries S, Grivell LA, (1991) Isolation and inactivation of the nuclear gene encoding the rotenone-insensitive internal NADH: ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J of Biochem 195: 857-862.
11. de Vries S, Van Witzenburg R, Grivell LA, Marres CAM, (1992) Primary structure and import pathway of the rotenone-insensitive NADH-ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J of Biochem 203: 587-592.
12. Kitajima-Ihara T, Yagi T, (1998) Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. FEBS Letters 421: 37-40.
13. Seo BB, Wang J, Flotte TR, Yagi T, Matsuno-Yagi A, (2000) Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells. J Biol Chem 275: 37774-8.
14. Seo BB, Kitajima-Ihara T, Chan EK, Scheffler IE, Matsuno-Yagi A, et al. (1998) Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc Natl Acad Sci USA 95: 9167-71.
15. Seo BB, Nakamaru-Ogiso E, Flotte TR, Matsuno-Yagi A, Yagi T, (2006) In vivo complementation of complex I by the yeast Ndi1 enzyme: possible application for treatment of Parkinson disease. J Biol Chem 281: 14250-5.
16. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, et al. (1998) HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 95: 2979-84.
17. Iwaki K, Sukhatme VP, Shubeita HE, Chien KR, (1990) Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. J Bio Chem 265: 13809-13817.
18. He H, Li HL, Lin A, Gottlieb RA, (1999) Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ 6: 987-991.
19. Chen M, Won DJ, Krajewski S, Gottlieb RA, (2002) Calpain and mitochondria in ischemia/reperfusion injury. J Biol Chem 277: 29181-29186.
20. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, et al. (2004) Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci USA 101: 1321-1326.
21. Miller FJJ, Gutterman DD, Rios CD, Heistad DD, Davidson BL, (1998) Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 82: 1298-1305.
22. Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA, (2003) Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol 284: C562-70.
23. Pain T, Yang XM, Critz SD, Yue Y, Nakano A, et al. (2000) Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 87: 460-466.
24. Becker-Hapak M, Dowdy SF, (2003) Protein transduction: generation of full-length transducible proteins using the TAT system. Curr Protoc Cell Biol Chapter 20: Unit 20.2.
25. Gustafsson AB, Sayen MR, Williams SD, Crow MT, Gottlieb RA, (2002) TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation 106 (6): 735-9.
26. Gustafsson AB, Gottlieb RA, Granville DJ, (2005) TAT-mediated protein transduction: delivering biologically active proteins to the heart. Methods Mol Med 112: 81-90.
27. Becker-Hapak M, McAllister SS, Dowdy SF, (2001) TAT-mediated protein transduction into mammalian cells. Methods 24 (3): 247-56.
28. Paradies G, Petrosillo G, Pistolese M, Di Venosa N, Serena D, et al. (1999) Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion. Free Rad Biol Med 27: 42-50.
29. Lesnefsky EJ, Slabe TJ, Stoll MS, Minler PE, Hoppel CL, (2001) Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria. Am J Physiol Heart Circ Phys 280: H2770-H2778.
30. Petrosillo G, Ruggiero FM, Di Venosa N, Paradies G, (2003) Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin. FASEB J 17: 714-716.
31. Lesnefsky EJ, Chen Q, Moghaddas S, Hassan MO, Tandler B, et al. (2004) Blockade of electron transport during ischemia protects cardiac mitochondria. J Biol Chem 279 (46): 47961-7.
32. Kussmaul L, Hirst J, (2006) The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A 103: 7607-12.
33. Lesnefsky EJ, Tandler B, Ye J, Slabe TJ, Turkaly J, (1997) Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria. Am J Physiol 273: H1544-54.
34. Fang J, Beattie DS, (2003) External alternative NADH dehydrogenase of Saccharomyces cerevisiae: a potential source of superoxide. Free Rad Bio Med 34: 478.
35. Marella M, Seo BB, Matsuno-Yagi A, Yagi T, (2007) Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line. J Biol Chem 282: 24146-56.
36. Seo BB, Marella M, Yagi T, Matsuno-Yagi A, (2006) The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I. FEBS Lett 580: 6105-8.
37. Kim CH, Woo SJ, Park JS, Kim HS, Park MY, et al. (2007) Enhanced antitumour immunity by combined use of temozolomide and TAT-survivin pulsed dendritic cells in a murine glioma. Immunology 122 (4): 615-22.
38. Bates E, Bode C, Costa M, Gibson CM, Granger C, et al. (2008) Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117 (7): 886-96.
39. Bright R, Steinberg GK, Mochly-Rosen D, (2007) DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res 1144: 146-55.
40. Ma H, Guo R, Yu L, Zhang Y, Ren J, (2010) Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J.
41. Siegel C, McCullough LD, (2010) NAD+ Depletion or PAR Polymer Formation: Which Plays the Role of Executioner in Ischemic Cell Death? Acta Physiol.
42. Sanz A, Soikkeli M, Portero-Otin M, Wilson A, Kemppainen E, et al. (2010) Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. PNAS 107 (20): 9105-9110.