Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide

Journal of Periodontal Research

Volumn 46, Issue 2, 2011, Pages 280-284

  Soysa, N S ^a,b   Alles, N ^a,b   Takahashi, M ^a   Aoki, K ^a   Ohya, K ^a  

^a Graduate School Tokyo Medical and Dental University ^*  (Japan)

^b UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

aly aly mice; Lipopolysaccharide; Nuclear factor B inducing kinase

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; LIPOPOLYSACCHARIDE; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL; ARTICLE; BONE DENSITY; C57BL MOUSE; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFECT; IMAGE PROCESSING; METHODOLOGY; MOUSE; MOUSE MUTANT; MOUSE STRAIN; OSTEITIS; OSTEOCLAST; OSTEOLYSIS; PATHOLOGY; PHYSIOLOGY; SKULL; THREE DIMENSIONAL IMAGING;

ACID PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BONE DENSITY; BONE RESORPTION; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; ISOENZYMES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; NF-KAPPA B; NF-KAPPA B P52 SUBUNIT; OSTEITIS; OSTEOCLASTS; PROTEIN-SERINE-THREONINE KINASES; SKULL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79951940565     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01333.x     Document Type: Article

References (16)

1. Nair SP, Meghji S, Wilson M, Reddi K, White P, Henderson B. Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 1996;64:2371-2380.
2. Soysa NS, Alles N. NF-kappaB functions in osteoclasts. Biochem Biophys Res Commun 2009;378:1-5.
3. Guo F, Tanzer S, Busslinger M, Weih F. Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis. Blood 2008;112:551-559.
4. Yao Z, Xing L, Boyce BF. NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest 2009;119:3024-3034.
5. Soysa NS, Alles N, Weih D et al. The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res 2010;25:809-818.
6. Clohisy JC, Roy BC, Biondo C et al. Direct inhibition of NF-κB blocks bone erosion associated with inflammatory arthritis. J Immunol 2003;171:5547-5553.
7. Jimi E, Aoki K, Saito H et al. Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004;10:617-624.
8. Hussain Mian A, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. J Bone Miner Metab 2008;26:469-477.
9. Alles N, Soysa NS, Hussain MD et al. Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Eur J Pharm Sci 2009;37:83-88.
10. Alles N, Soysa NS, Hayashi J et al. Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Endocrinology 2010;151:4626-4634.
11. Islam S, Hassan F, Tumurkhuu G et al. Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells. Biochem Biophys Res Commun 2007;360:346-351.
12. Abu-Amer Y, Ross FP, Edwards J, Teitelbaum SL. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. J Clin Invest 1997;100:1557-1565.
13. Tomomatsu N, Aoki K, Alles N et al. LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model. J Bone Miner Res 2009;24:1770-1781.
14. Dai S, Hirayama T, Abbas S, Abu-Amer Y. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 2004;279:37219-37222.
15. Aya K, Alhawagri M, Hagen-Stapleton A, Kitaura H, Kanagawa O, Novack DV. NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest 2005;115:1848-1854.
16. Pan Q, Kravchenko V, Katz A et al. NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun 2006;74:2121-2127.