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3 (3 mol%) afforded 2a in 91% yield
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The reaction of 1a in aqueous EtOH did not produce 2a even in the presence of acetaldoxime, and the reason is not clear at this stage. The hydration of cyanamide can be performed under solvent-free conditions. As an example, the reaction of 1a and acetaldoxime (3.0 equiv) at room temperature in the presence of InCl3 (3 mol%) afforded 2a in 91% yield.
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