Evaluation of factor VIII pharmacokinetics and anti-factor VIII antibodies in four boys with haemophilia A and a poor clinical response to factor VIII

Haemophilia

Volumn 17, Issue 1, 2011, Pages 155-156

  Kempton, C L ^a   Meeks, S L ^a   Donald Harvey, R ^a   Abshire, T C ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; KOGONATE FS; RECOMBINANT BLOOD CLOTTING FACTOR 8; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AREA UNDER THE CURVE; CASE REPORT; CHILD; DISTRIBUTION VOLUME; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG HALF LIFE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOPHILIA A; HUMAN; LETTER; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICAL INFORMATION; PARTIAL THROMBOPLASTIN TIME; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TREATMENT RESPONSE;

ANTIBODIES; BLOOD COAGULATION FACTOR INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VIII; HEMOPHILIA A; HUMANS; INFANT; MALE; PARTIAL THROMBOPLASTIN TIME; TREATMENT OUTCOME;

EID: 79951937307     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2010.02345.x     Document Type: Letter

References (4)

1. Dazzi F, Tison T, Vianello F et al. High incidence of anti-FVIII antibodies against non-coagulant epitopes in haemophilia A patients: a possible role for the half-life of transfused FVIII. Br J Haematol 1996; 93: 688-93.
2. Barrow RT, Lollar P. Neutralization of antifactor VIII inhibitors by recombinant porcine factor VIII. J Thromb Haemost 2006; 4: 2223-9.
3. Blanchette VS, Shapiro AD, Liesner RJ et al. Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients. J Thromb Haemost 2008; 6: 1319-26.
4. Collins PW, Blanchette VS, Fischer K et al. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. J Thromb Haemost 2009; 7: 413-20.